| Full name: regulator of G protein signaling 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q24.2 | ||
| Entrez ID: 9628 | HGNC ID: HGNC:10002 | Ensembl Gene: ENSG00000182732 | OMIM ID: 603894 |
| Drug and gene relationship at DGIdb | |||
Expression of RGS6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RGS6 | 9628 | 210270_at | 0.2449 | 0.3109 | |
| GSE20347 | RGS6 | 9628 | 210270_at | 0.2007 | 0.1592 | |
| GSE23400 | RGS6 | 9628 | 210270_at | 0.0137 | 0.7697 | |
| GSE26886 | RGS6 | 9628 | 214538_x_at | 0.1412 | 0.1617 | |
| GSE29001 | RGS6 | 9628 | 214538_x_at | -0.0228 | 0.9122 | |
| GSE38129 | RGS6 | 9628 | 210270_at | 0.1342 | 0.3203 | |
| GSE45670 | RGS6 | 9628 | 211448_s_at | -0.0864 | 0.4941 | |
| GSE53622 | RGS6 | 9628 | 125881 | -0.3242 | 0.1203 | |
| GSE53624 | RGS6 | 9628 | 77186 | 0.1238 | 0.1486 | |
| GSE63941 | RGS6 | 9628 | 214538_x_at | 0.1868 | 0.3456 | |
| GSE77861 | RGS6 | 9628 | 214538_x_at | 0.1155 | 0.3461 | |
| SRP133303 | RGS6 | 9628 | RNAseq | -0.9229 | 0.0639 | |
| SRP159526 | RGS6 | 9628 | RNAseq | 1.7059 | 0.0031 | |
| SRP219564 | RGS6 | 9628 | RNAseq | 1.3751 | 0.0141 | |
| TCGA | RGS6 | 9628 | RNAseq | 0.0615 | 0.8856 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by RGS6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RGS6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RGS6 | 9628 | 8 | 3 | 19 | |
| GSE20123 | RGS6 | 9628 | 8 | 3 | 19 | |
| GSE43470 | RGS6 | 9628 | 8 | 3 | 32 | |
| GSE46452 | RGS6 | 9628 | 16 | 3 | 40 | |
| GSE47630 | RGS6 | 9628 | 11 | 9 | 20 | |
| GSE54993 | RGS6 | 9628 | 3 | 9 | 58 | |
| GSE54994 | RGS6 | 9628 | 19 | 5 | 29 | |
| GSE60625 | RGS6 | 9628 | 0 | 2 | 9 | |
| GSE74703 | RGS6 | 9628 | 7 | 3 | 26 | |
| GSE74704 | RGS6 | 9628 | 3 | 3 | 14 | |
| TCGA | RGS6 | 9628 | 32 | 16 | 48 |
Total number of gains: 115; Total number of losses: 59; Total Number of normals: 314.
Somatic mutations of RGS6:
Generating mutation plots.
Highly correlated genes for RGS6:
Showing top 20/567 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RGS6 | TNFSF8 | 0.726588 | 3 | 0 | 3 |
| RGS6 | LUZP4 | 0.704662 | 4 | 0 | 4 |
| RGS6 | CHST5 | 0.694981 | 4 | 0 | 4 |
| RGS6 | FOXN3-AS2 | 0.685018 | 4 | 0 | 4 |
| RGS6 | PDCD2L | 0.684266 | 3 | 0 | 3 |
| RGS6 | CMKLR1 | 0.677494 | 3 | 0 | 3 |
| RGS6 | S1PR4 | 0.674555 | 4 | 0 | 4 |
| RGS6 | ERF | 0.672954 | 4 | 0 | 4 |
| RGS6 | KIR3DL3 | 0.67188 | 5 | 0 | 5 |
| RGS6 | NOVA2 | 0.670186 | 4 | 0 | 3 |
| RGS6 | GPA33 | 0.66086 | 4 | 0 | 3 |
| RGS6 | CYP3A4 | 0.658263 | 4 | 0 | 3 |
| RGS6 | CCDC9 | 0.656193 | 6 | 0 | 6 |
| RGS6 | NTNG1 | 0.654463 | 4 | 0 | 4 |
| RGS6 | RBFADN | 0.651658 | 5 | 0 | 4 |
| RGS6 | CNGB3 | 0.649575 | 5 | 0 | 4 |
| RGS6 | SH2B2 | 0.649411 | 5 | 0 | 5 |
| RGS6 | KCNA1 | 0.64799 | 4 | 0 | 3 |
| RGS6 | POU5F1B | 0.647335 | 6 | 0 | 5 |
| RGS6 | SLC30A3 | 0.646719 | 5 | 0 | 4 |
For details and further investigation, click here
