| Full name: transmembrane serine protease 5 | Alias Symbol: MGC141886|MGC148044 | ||
| Type: protein-coding gene | Cytoband: 11q23.2 | ||
| Entrez ID: 80975 | HGNC ID: HGNC:14908 | Ensembl Gene: ENSG00000166682 | OMIM ID: 606751 |
| Drug and gene relationship at DGIdb | |||
Expression of TMPRSS5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMPRSS5 | 80975 | 221032_s_at | 0.1031 | 0.6659 | |
| GSE20347 | TMPRSS5 | 80975 | 221032_s_at | 0.1179 | 0.3368 | |
| GSE23400 | TMPRSS5 | 80975 | 221032_s_at | -0.0894 | 0.0286 | |
| GSE26886 | TMPRSS5 | 80975 | 221032_s_at | 0.0540 | 0.7709 | |
| GSE29001 | TMPRSS5 | 80975 | 221032_s_at | -0.0707 | 0.7754 | |
| GSE38129 | TMPRSS5 | 80975 | 221032_s_at | -0.0501 | 0.6191 | |
| GSE45670 | TMPRSS5 | 80975 | 221032_s_at | 0.0679 | 0.6358 | |
| GSE53622 | TMPRSS5 | 80975 | 82232 | -0.4177 | 0.0068 | |
| GSE53624 | TMPRSS5 | 80975 | 82232 | -0.6630 | 0.0000 | |
| GSE63941 | TMPRSS5 | 80975 | 221032_s_at | 0.1907 | 0.3539 | |
| GSE77861 | TMPRSS5 | 80975 | 221032_s_at | -0.0285 | 0.8514 | |
| GSE97050 | TMPRSS5 | 80975 | A_33_P3286923 | -0.3297 | 0.2903 | |
| SRP133303 | TMPRSS5 | 80975 | RNAseq | -1.1469 | 0.0088 | |
| SRP159526 | TMPRSS5 | 80975 | RNAseq | 0.7691 | 0.4214 | |
| SRP219564 | TMPRSS5 | 80975 | RNAseq | -0.3710 | 0.4359 | |
| TCGA | TMPRSS5 | 80975 | RNAseq | -1.5612 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by TMPRSS5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMPRSS5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMPRSS5 | 80975 | 0 | 13 | 17 | |
| GSE20123 | TMPRSS5 | 80975 | 0 | 13 | 17 | |
| GSE43470 | TMPRSS5 | 80975 | 2 | 7 | 34 | |
| GSE46452 | TMPRSS5 | 80975 | 3 | 26 | 30 | |
| GSE47630 | TMPRSS5 | 80975 | 2 | 19 | 19 | |
| GSE54993 | TMPRSS5 | 80975 | 10 | 0 | 60 | |
| GSE54994 | TMPRSS5 | 80975 | 5 | 19 | 29 | |
| GSE60625 | TMPRSS5 | 80975 | 0 | 3 | 8 | |
| GSE74703 | TMPRSS5 | 80975 | 1 | 5 | 30 | |
| GSE74704 | TMPRSS5 | 80975 | 0 | 9 | 11 | |
| TCGA | TMPRSS5 | 80975 | 5 | 49 | 42 |
Total number of gains: 28; Total number of losses: 163; Total Number of normals: 297.
Somatic mutations of TMPRSS5:
Generating mutation plots.
Highly correlated genes for TMPRSS5:
Showing top 20/1051 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMPRSS5 | LRTM2 | 0.74437 | 3 | 0 | 3 |
| TMPRSS5 | SORCS2 | 0.73461 | 3 | 0 | 3 |
| TMPRSS5 | OSBPL5 | 0.724664 | 3 | 0 | 3 |
| TMPRSS5 | PGC | 0.720512 | 3 | 0 | 3 |
| TMPRSS5 | SYT12 | 0.719902 | 6 | 0 | 6 |
| TMPRSS5 | PPP1R14D | 0.708633 | 5 | 0 | 4 |
| TMPRSS5 | FUT7 | 0.698462 | 4 | 0 | 4 |
| TMPRSS5 | CYP2D6 | 0.69781 | 7 | 0 | 7 |
| TMPRSS5 | AQP4 | 0.697529 | 3 | 0 | 3 |
| TMPRSS5 | CHAT | 0.697224 | 5 | 0 | 5 |
| TMPRSS5 | C8A | 0.696923 | 5 | 0 | 5 |
| TMPRSS5 | OR10H1 | 0.694916 | 7 | 0 | 7 |
| TMPRSS5 | CCDC87 | 0.694593 | 4 | 0 | 4 |
| TMPRSS5 | ARHGEF38 | 0.691421 | 5 | 0 | 5 |
| TMPRSS5 | NTNG1 | 0.690931 | 4 | 0 | 4 |
| TMPRSS5 | CCDC170 | 0.689778 | 5 | 0 | 5 |
| TMPRSS5 | AOC2 | 0.68964 | 5 | 0 | 5 |
| TMPRSS5 | NKAIN4 | 0.689389 | 4 | 0 | 3 |
| TMPRSS5 | LUZP4 | 0.68919 | 5 | 0 | 4 |
| TMPRSS5 | ARHGEF17 | 0.686741 | 3 | 0 | 3 |
For details and further investigation, click here
