| Full name: REV3 like, DNA directed polymerase zeta catalytic subunit | Alias Symbol: POLZ|REV3 | ||
| Type: protein-coding gene | Cytoband: 6q21 | ||
| Entrez ID: 5980 | HGNC ID: HGNC:9968 | Ensembl Gene: ENSG00000009413 | OMIM ID: 602776 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of REV3L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | REV3L | 5980 | 208070_s_at | -0.6569 | 0.1052 | |
| GSE20347 | REV3L | 5980 | 208070_s_at | 0.3107 | 0.0453 | |
| GSE23400 | REV3L | 5980 | 208070_s_at | 0.3005 | 0.0024 | |
| GSE26886 | REV3L | 5980 | 208070_s_at | 1.0349 | 0.0001 | |
| GSE29001 | REV3L | 5980 | 208070_s_at | 0.7268 | 0.0164 | |
| GSE38129 | REV3L | 5980 | 208070_s_at | 0.1337 | 0.4595 | |
| GSE45670 | REV3L | 5980 | 208070_s_at | -0.6890 | 0.0001 | |
| GSE53622 | REV3L | 5980 | 12874 | 1.1297 | 0.0000 | |
| GSE53624 | REV3L | 5980 | 12874 | 0.7419 | 0.0000 | |
| GSE63941 | REV3L | 5980 | 208070_s_at | -1.7160 | 0.0011 | |
| GSE77861 | REV3L | 5980 | 208070_s_at | 0.5970 | 0.0895 | |
| GSE97050 | REV3L | 5980 | A_23_P214139 | -0.0403 | 0.8518 | |
| SRP007169 | REV3L | 5980 | RNAseq | 1.3929 | 0.0001 | |
| SRP008496 | REV3L | 5980 | RNAseq | 1.0903 | 0.0000 | |
| SRP064894 | REV3L | 5980 | RNAseq | -0.1865 | 0.5939 | |
| SRP133303 | REV3L | 5980 | RNAseq | -0.2097 | 0.1160 | |
| SRP159526 | REV3L | 5980 | RNAseq | -0.1242 | 0.5685 | |
| SRP193095 | REV3L | 5980 | RNAseq | 0.2433 | 0.0176 | |
| SRP219564 | REV3L | 5980 | RNAseq | -0.3689 | 0.3714 | |
| TCGA | REV3L | 5980 | RNAseq | -0.2256 | 0.0001 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by REV3L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of REV3L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | REV3L | 5980 | 2 | 4 | 24 | |
| GSE20123 | REV3L | 5980 | 2 | 3 | 25 | |
| GSE43470 | REV3L | 5980 | 3 | 1 | 39 | |
| GSE46452 | REV3L | 5980 | 2 | 11 | 46 | |
| GSE47630 | REV3L | 5980 | 9 | 4 | 27 | |
| GSE54993 | REV3L | 5980 | 3 | 2 | 65 | |
| GSE54994 | REV3L | 5980 | 8 | 8 | 37 | |
| GSE60625 | REV3L | 5980 | 0 | 2 | 9 | |
| GSE74703 | REV3L | 5980 | 2 | 1 | 33 | |
| GSE74704 | REV3L | 5980 | 0 | 1 | 19 | |
| TCGA | REV3L | 5980 | 6 | 23 | 67 |
Total number of gains: 37; Total number of losses: 60; Total Number of normals: 391.
Somatic mutations of REV3L:
Generating mutation plots.
Highly correlated genes for REV3L:
Showing top 20/639 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| REV3L | ASB3 | 0.910145 | 3 | 0 | 3 |
| REV3L | ALG11 | 0.867971 | 3 | 0 | 3 |
| REV3L | KLHL13 | 0.798267 | 3 | 0 | 3 |
| REV3L | TWISTNB | 0.766816 | 3 | 0 | 3 |
| REV3L | TMEM132C | 0.765908 | 3 | 0 | 3 |
| REV3L | ZCCHC3 | 0.729457 | 3 | 0 | 3 |
| REV3L | KCNE3 | 0.726398 | 3 | 0 | 3 |
| REV3L | AADAT | 0.72557 | 3 | 0 | 3 |
| REV3L | UBR1 | 0.723552 | 5 | 0 | 5 |
| REV3L | KLHL5 | 0.717324 | 4 | 0 | 4 |
| REV3L | CXCL5 | 0.716594 | 4 | 0 | 4 |
| REV3L | RFX7 | 0.711544 | 4 | 0 | 3 |
| REV3L | PLEKHA3 | 0.695795 | 4 | 0 | 3 |
| REV3L | HSD11B1 | 0.689877 | 4 | 0 | 3 |
| REV3L | TGFBR1 | 0.688454 | 4 | 0 | 3 |
| REV3L | TRIM35 | 0.685483 | 3 | 0 | 3 |
| REV3L | RTTN | 0.6818 | 3 | 0 | 3 |
| REV3L | KIAA0895L | 0.680397 | 3 | 0 | 3 |
| REV3L | C11orf96 | 0.678777 | 5 | 0 | 5 |
| REV3L | ATP11C | 0.67772 | 5 | 0 | 3 |
For details and further investigation, click here
