| Full name: hydroxysteroid 11-beta dehydrogenase 1 | Alias Symbol: SDR26C1 | ||
| Type: protein-coding gene | Cytoband: 1q32.2 | ||
| Entrez ID: 3290 | HGNC ID: HGNC:5208 | Ensembl Gene: ENSG00000117594 | OMIM ID: 600713 |
| Drug and gene relationship at DGIdb | |||
Expression of HSD11B1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSD11B1 | 3290 | 205404_at | 0.1945 | 0.8796 | |
| GSE20347 | HSD11B1 | 3290 | 205404_at | 0.1051 | 0.1895 | |
| GSE23400 | HSD11B1 | 3290 | 205404_at | -0.0555 | 0.2958 | |
| GSE26886 | HSD11B1 | 3290 | 205404_at | -0.0048 | 0.9767 | |
| GSE29001 | HSD11B1 | 3290 | 205404_at | -0.0110 | 0.9564 | |
| GSE38129 | HSD11B1 | 3290 | 205404_at | -0.1293 | 0.6480 | |
| GSE45670 | HSD11B1 | 3290 | 205404_at | -0.4831 | 0.1262 | |
| GSE53622 | HSD11B1 | 3290 | 140208 | 1.2554 | 0.0000 | |
| GSE53624 | HSD11B1 | 3290 | 140208 | 1.3639 | 0.0000 | |
| GSE63941 | HSD11B1 | 3290 | 205404_at | -5.2713 | 0.0000 | |
| GSE77861 | HSD11B1 | 3290 | 205404_at | -0.0324 | 0.7776 | |
| GSE97050 | HSD11B1 | 3290 | A_23_P63209 | 0.1419 | 0.5221 | |
| SRP064894 | HSD11B1 | 3290 | RNAseq | 1.8233 | 0.0000 | |
| SRP133303 | HSD11B1 | 3290 | RNAseq | 2.3321 | 0.0000 | |
| SRP159526 | HSD11B1 | 3290 | RNAseq | 2.4655 | 0.0000 | |
| SRP219564 | HSD11B1 | 3290 | RNAseq | 1.4250 | 0.1462 | |
| TCGA | HSD11B1 | 3290 | RNAseq | -0.6420 | 0.0307 |
Upregulated datasets: 5; Downregulated datasets: 1.
Survival by HSD11B1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSD11B1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSD11B1 | 3290 | 11 | 0 | 19 | |
| GSE20123 | HSD11B1 | 3290 | 10 | 0 | 20 | |
| GSE43470 | HSD11B1 | 3290 | 7 | 0 | 36 | |
| GSE46452 | HSD11B1 | 3290 | 3 | 1 | 55 | |
| GSE47630 | HSD11B1 | 3290 | 15 | 0 | 25 | |
| GSE54993 | HSD11B1 | 3290 | 0 | 6 | 64 | |
| GSE54994 | HSD11B1 | 3290 | 14 | 0 | 39 | |
| GSE60625 | HSD11B1 | 3290 | 0 | 0 | 11 | |
| GSE74703 | HSD11B1 | 3290 | 7 | 0 | 29 | |
| GSE74704 | HSD11B1 | 3290 | 4 | 0 | 16 | |
| TCGA | HSD11B1 | 3290 | 44 | 3 | 49 |
Total number of gains: 115; Total number of losses: 10; Total Number of normals: 363.
Somatic mutations of HSD11B1:
Generating mutation plots.
Highly correlated genes for HSD11B1:
Showing top 20/1062 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSD11B1 | FCGR3A | 0.80224 | 3 | 0 | 3 |
| HSD11B1 | RBL2 | 0.788757 | 3 | 0 | 3 |
| HSD11B1 | LRRK2 | 0.780391 | 3 | 0 | 3 |
| HSD11B1 | STARD3NL | 0.779071 | 4 | 0 | 4 |
| HSD11B1 | ANKRD44 | 0.764135 | 4 | 0 | 3 |
| HSD11B1 | UXS1 | 0.759604 | 3 | 0 | 3 |
| HSD11B1 | UBB | 0.758203 | 3 | 0 | 3 |
| HSD11B1 | SEC22C | 0.755767 | 4 | 0 | 4 |
| HSD11B1 | RNF130 | 0.752756 | 6 | 0 | 6 |
| HSD11B1 | ZNF382 | 0.749908 | 3 | 0 | 3 |
| HSD11B1 | GPC6 | 0.739728 | 6 | 0 | 5 |
| HSD11B1 | FAM155A | 0.737083 | 7 | 0 | 7 |
| HSD11B1 | DERL3 | 0.735226 | 3 | 0 | 3 |
| HSD11B1 | DCHS1 | 0.734849 | 6 | 0 | 6 |
| HSD11B1 | ASPA | 0.72984 | 4 | 0 | 3 |
| HSD11B1 | CERKL | 0.727949 | 3 | 0 | 3 |
| HSD11B1 | EFEMP2 | 0.722993 | 8 | 0 | 6 |
| HSD11B1 | PXK | 0.722087 | 3 | 0 | 3 |
| HSD11B1 | RAB34 | 0.720027 | 3 | 0 | 3 |
| HSD11B1 | SNX25 | 0.719774 | 4 | 0 | 3 |
For details and further investigation, click here
