| Full name: regulator of G protein signaling 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 5999 | HGNC ID: HGNC:10000 | Ensembl Gene: ENSG00000117152 | OMIM ID: 602516 |
| Drug and gene relationship at DGIdb | |||
Expression of RGS4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RGS4 | 5999 | 204337_at | -0.0624 | 0.9723 | |
| GSE20347 | RGS4 | 5999 | 204337_at | 0.3550 | 0.3399 | |
| GSE23400 | RGS4 | 5999 | 204337_at | -0.1352 | 0.4837 | |
| GSE26886 | RGS4 | 5999 | 204337_at | -0.0596 | 0.9021 | |
| GSE29001 | RGS4 | 5999 | 204337_at | -0.2467 | 0.6062 | |
| GSE38129 | RGS4 | 5999 | 204337_at | -0.1948 | 0.7021 | |
| GSE45670 | RGS4 | 5999 | 204337_at | -0.5382 | 0.3356 | |
| GSE53622 | RGS4 | 5999 | 99008 | 0.7286 | 0.0022 | |
| GSE53624 | RGS4 | 5999 | 99008 | 1.0165 | 0.0000 | |
| GSE63941 | RGS4 | 5999 | 204337_at | -4.9084 | 0.0000 | |
| GSE77861 | RGS4 | 5999 | 204339_s_at | -0.0299 | 0.8261 | |
| GSE97050 | RGS4 | 5999 | A_33_P3325009 | -0.0912 | 0.7297 | |
| SRP007169 | RGS4 | 5999 | RNAseq | 4.1544 | 0.0000 | |
| SRP008496 | RGS4 | 5999 | RNAseq | 3.9475 | 0.0000 | |
| SRP064894 | RGS4 | 5999 | RNAseq | 0.4139 | 0.2296 | |
| SRP133303 | RGS4 | 5999 | RNAseq | 0.7363 | 0.0357 | |
| SRP159526 | RGS4 | 5999 | RNAseq | 0.0753 | 0.9119 | |
| SRP193095 | RGS4 | 5999 | RNAseq | 1.5943 | 0.0000 | |
| SRP219564 | RGS4 | 5999 | RNAseq | -0.9694 | 0.2906 | |
| TCGA | RGS4 | 5999 | RNAseq | -0.1522 | 0.4856 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by RGS4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RGS4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RGS4 | 5999 | 10 | 0 | 20 | |
| GSE20123 | RGS4 | 5999 | 10 | 0 | 20 | |
| GSE43470 | RGS4 | 5999 | 7 | 2 | 34 | |
| GSE46452 | RGS4 | 5999 | 2 | 1 | 56 | |
| GSE47630 | RGS4 | 5999 | 14 | 0 | 26 | |
| GSE54993 | RGS4 | 5999 | 0 | 5 | 65 | |
| GSE54994 | RGS4 | 5999 | 16 | 0 | 37 | |
| GSE60625 | RGS4 | 5999 | 0 | 0 | 11 | |
| GSE74703 | RGS4 | 5999 | 7 | 2 | 27 | |
| GSE74704 | RGS4 | 5999 | 4 | 0 | 16 | |
| TCGA | RGS4 | 5999 | 42 | 3 | 51 |
Total number of gains: 112; Total number of losses: 13; Total Number of normals: 363.
Somatic mutations of RGS4:
Generating mutation plots.
Highly correlated genes for RGS4:
Showing top 20/131 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RGS4 | DNM3OS | 0.685563 | 4 | 0 | 3 |
| RGS4 | SHISA3 | 0.645774 | 3 | 0 | 3 |
| RGS4 | HEPH | 0.64574 | 11 | 0 | 10 |
| RGS4 | TUBA8 | 0.641795 | 3 | 0 | 3 |
| RGS4 | VAT1L | 0.640665 | 5 | 0 | 4 |
| RGS4 | RASSF8-AS1 | 0.637606 | 3 | 0 | 3 |
| RGS4 | MAGI2-AS3 | 0.630947 | 5 | 0 | 5 |
| RGS4 | FSIP1 | 0.629669 | 3 | 0 | 3 |
| RGS4 | PTGFR | 0.627483 | 7 | 0 | 7 |
| RGS4 | SYT11 | 0.626636 | 9 | 0 | 7 |
| RGS4 | NAP1L3 | 0.61974 | 8 | 0 | 5 |
| RGS4 | RARRES2 | 0.619626 | 10 | 0 | 8 |
| RGS4 | NCALD | 0.615796 | 4 | 0 | 3 |
| RGS4 | CACNG8 | 0.615692 | 3 | 0 | 3 |
| RGS4 | RASGRF2 | 0.615345 | 6 | 0 | 5 |
| RGS4 | ALKBH5 | 0.610066 | 3 | 0 | 3 |
| RGS4 | PKDCC | 0.609886 | 6 | 0 | 4 |
| RGS4 | MICAL2 | 0.609767 | 11 | 0 | 8 |
| RGS4 | GPM6A | 0.60969 | 7 | 0 | 5 |
| RGS4 | CRYGA | 0.606167 | 3 | 0 | 3 |
For details and further investigation, click here
