| Full name: POU class 5 homeobox 1B | Alias Symbol: OTF3C | ||
| Type: protein-coding gene | Cytoband: 8q24.21 | ||
| Entrez ID: 5462 | HGNC ID: HGNC:9223 | Ensembl Gene: ENSG00000212993 | OMIM ID: 615739 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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POU5F1B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04550 | Signaling pathways regulating pluripotency of stem cells |
Expression of POU5F1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POU5F1B | 5462 | 214532_x_at | 0.1870 | 0.5273 | |
| GSE20347 | POU5F1B | 5462 | 214532_x_at | 0.1860 | 0.0499 | |
| GSE23400 | POU5F1B | 5462 | 214532_x_at | 0.0683 | 0.1280 | |
| GSE26886 | POU5F1B | 5462 | 214532_x_at | 0.1161 | 0.4608 | |
| GSE29001 | POU5F1B | 5462 | 214532_x_at | 0.0155 | 0.9434 | |
| GSE38129 | POU5F1B | 5462 | 214532_x_at | 0.0514 | 0.6414 | |
| GSE45670 | POU5F1B | 5462 | 214532_x_at | 0.2564 | 0.1072 | |
| GSE63941 | POU5F1B | 5462 | 214532_x_at | 0.6017 | 0.0488 | |
| GSE77861 | POU5F1B | 5462 | 214532_x_at | 0.0431 | 0.7529 | |
| TCGA | POU5F1B | 5462 | RNAseq | -0.0996 | 0.7033 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by POU5F1B expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of POU5F1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POU5F1B | 5462 | 23 | 0 | 7 | |
| GSE20123 | POU5F1B | 5462 | 23 | 0 | 7 | |
| GSE43470 | POU5F1B | 5462 | 23 | 0 | 20 | |
| GSE46452 | POU5F1B | 5462 | 30 | 0 | 29 | |
| GSE47630 | POU5F1B | 5462 | 25 | 0 | 15 | |
| GSE54993 | POU5F1B | 5462 | 0 | 22 | 48 | |
| GSE54994 | POU5F1B | 5462 | 41 | 0 | 12 | |
| GSE60625 | POU5F1B | 5462 | 0 | 7 | 4 | |
| GSE74703 | POU5F1B | 5462 | 19 | 0 | 17 | |
| GSE74704 | POU5F1B | 5462 | 15 | 0 | 5 | |
| TCGA | POU5F1B | 5462 | 70 | 1 | 25 |
Total number of gains: 269; Total number of losses: 30; Total Number of normals: 189.
Somatic mutations of POU5F1B:
Generating mutation plots.
Highly correlated genes for POU5F1B:
Showing top 20/440 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POU5F1B | GPA33 | 0.75391 | 3 | 0 | 3 |
| POU5F1B | MYO7A | 0.745341 | 3 | 0 | 3 |
| POU5F1B | FOXA2 | 0.718376 | 3 | 0 | 3 |
| POU5F1B | LENEP | 0.715756 | 6 | 0 | 6 |
| POU5F1B | CDH4 | 0.693493 | 4 | 0 | 4 |
| POU5F1B | BRDT | 0.681824 | 3 | 0 | 3 |
| POU5F1B | FBXW12 | 0.676497 | 4 | 0 | 4 |
| POU5F1B | RNF185-AS1 | 0.676069 | 3 | 0 | 3 |
| POU5F1B | OGFR | 0.67279 | 3 | 0 | 3 |
| POU5F1B | ANKRD10-IT1 | 0.671143 | 4 | 0 | 4 |
| POU5F1B | CHRM5 | 0.670797 | 4 | 0 | 4 |
| POU5F1B | NTNG1 | 0.663335 | 3 | 0 | 3 |
| POU5F1B | PLA2G2D | 0.66186 | 3 | 0 | 3 |
| POU5F1B | CCR8 | 0.658615 | 4 | 0 | 3 |
| POU5F1B | GAD2 | 0.657507 | 3 | 0 | 3 |
| POU5F1B | ZNF160 | 0.654718 | 3 | 0 | 3 |
| POU5F1B | PLCB2 | 0.65137 | 5 | 0 | 5 |
| POU5F1B | EHD1 | 0.650613 | 3 | 0 | 3 |
| POU5F1B | SPRN | 0.648825 | 3 | 0 | 3 |
| POU5F1B | SOAT2 | 0.647975 | 3 | 0 | 3 |
For details and further investigation, click here
