| Full name: serpin family B member 1 | Alias Symbol: EI|PI2|anti-elastase | ||
| Type: protein-coding gene | Cytoband: 6p25.2 | ||
| Entrez ID: 1992 | HGNC ID: HGNC:3311 | Ensembl Gene: ENSG00000021355 | OMIM ID: 130135 |
| Drug and gene relationship at DGIdb | |||
Expression of SERPINB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERPINB1 | 1992 | 212268_at | -2.1060 | 0.1483 | |
| GSE20347 | SERPINB1 | 1992 | 213572_s_at | -2.9625 | 0.0000 | |
| GSE23400 | SERPINB1 | 1992 | 212268_at | -2.5995 | 0.0000 | |
| GSE26886 | SERPINB1 | 1992 | 212268_at | -4.0860 | 0.0000 | |
| GSE29001 | SERPINB1 | 1992 | 212268_at | -3.3382 | 0.0000 | |
| GSE38129 | SERPINB1 | 1992 | 213572_s_at | -2.2834 | 0.0000 | |
| GSE45670 | SERPINB1 | 1992 | 213572_s_at | -0.6181 | 0.1062 | |
| GSE53622 | SERPINB1 | 1992 | 21522 | -2.7323 | 0.0000 | |
| GSE53624 | SERPINB1 | 1992 | 21522 | -2.9905 | 0.0000 | |
| GSE63941 | SERPINB1 | 1992 | 213572_s_at | -0.6494 | 0.7249 | |
| GSE77861 | SERPINB1 | 1992 | 213572_s_at | -1.7450 | 0.0077 | |
| GSE97050 | SERPINB1 | 1992 | A_23_P214330 | -1.1711 | 0.2297 | |
| SRP007169 | SERPINB1 | 1992 | RNAseq | -4.7852 | 0.0000 | |
| SRP008496 | SERPINB1 | 1992 | RNAseq | -4.7885 | 0.0000 | |
| SRP064894 | SERPINB1 | 1992 | RNAseq | -3.2431 | 0.0000 | |
| SRP133303 | SERPINB1 | 1992 | RNAseq | -2.3188 | 0.0000 | |
| SRP159526 | SERPINB1 | 1992 | RNAseq | -3.8609 | 0.0000 | |
| SRP193095 | SERPINB1 | 1992 | RNAseq | -2.7279 | 0.0000 | |
| SRP219564 | SERPINB1 | 1992 | RNAseq | -2.9510 | 0.0001 | |
| TCGA | SERPINB1 | 1992 | RNAseq | -0.1064 | 0.3925 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by SERPINB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERPINB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERPINB1 | 1992 | 4 | 5 | 21 | |
| GSE20123 | SERPINB1 | 1992 | 4 | 5 | 21 | |
| GSE43470 | SERPINB1 | 1992 | 9 | 4 | 30 | |
| GSE46452 | SERPINB1 | 1992 | 1 | 10 | 48 | |
| GSE47630 | SERPINB1 | 1992 | 7 | 8 | 25 | |
| GSE54993 | SERPINB1 | 1992 | 1 | 1 | 68 | |
| GSE54994 | SERPINB1 | 1992 | 10 | 3 | 40 | |
| GSE60625 | SERPINB1 | 1992 | 0 | 1 | 10 | |
| GSE74703 | SERPINB1 | 1992 | 8 | 3 | 25 | |
| GSE74704 | SERPINB1 | 1992 | 2 | 2 | 16 | |
| TCGA | SERPINB1 | 1992 | 17 | 30 | 49 |
Total number of gains: 63; Total number of losses: 72; Total Number of normals: 353.
Somatic mutations of SERPINB1:
Generating mutation plots.
Highly correlated genes for SERPINB1:
Showing top 20/1786 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERPINB1 | ZNF185 | 0.880256 | 12 | 0 | 12 |
| SERPINB1 | TGM1 | 0.878473 | 12 | 0 | 12 |
| SERPINB1 | ENDOU | 0.877798 | 11 | 0 | 11 |
| SERPINB1 | CYSRT1 | 0.86749 | 7 | 0 | 6 |
| SERPINB1 | ECM1 | 0.862999 | 12 | 0 | 12 |
| SERPINB1 | PPL | 0.859895 | 12 | 0 | 12 |
| SERPINB1 | CSTB | 0.858629 | 12 | 0 | 12 |
| SERPINB1 | CRISP3 | 0.855356 | 11 | 0 | 11 |
| SERPINB1 | A2ML1 | 0.854352 | 8 | 0 | 8 |
| SERPINB1 | ANXA1 | 0.853747 | 12 | 0 | 12 |
| SERPINB1 | MXD1 | 0.852416 | 12 | 0 | 12 |
| SERPINB1 | VSIG10L | 0.847009 | 7 | 0 | 7 |
| SERPINB1 | CLIC3 | 0.846824 | 11 | 0 | 10 |
| SERPINB1 | RHCG | 0.846655 | 12 | 0 | 12 |
| SERPINB1 | CNFN | 0.846133 | 8 | 0 | 8 |
| SERPINB1 | S100A14 | 0.846007 | 12 | 0 | 12 |
| SERPINB1 | EPGN | 0.845038 | 3 | 0 | 3 |
| SERPINB1 | FAM3D | 0.84474 | 7 | 0 | 7 |
| SERPINB1 | CRCT1 | 0.844579 | 12 | 0 | 12 |
| SERPINB1 | RAB11A | 0.840077 | 11 | 0 | 11 |
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