| Full name: RAR related orphan receptor B | Alias Symbol: RZRB|NR1F2|ROR-BETA | ||
| Type: protein-coding gene | Cytoband: 9q21.13 | ||
| Entrez ID: 6096 | HGNC ID: HGNC:10259 | Ensembl Gene: ENSG00000198963 | OMIM ID: 601972 |
| Drug and gene relationship at DGIdb | |||
RORB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04710 | Circadian rhythm |
Expression of RORB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RORB | 6096 | 231040_at | -0.2388 | 0.6015 | |
| GSE20347 | RORB | 6096 | 206443_at | 0.0301 | 0.7327 | |
| GSE23400 | RORB | 6096 | 206443_at | -0.0901 | 0.0045 | |
| GSE26886 | RORB | 6096 | 231040_at | 0.2281 | 0.5261 | |
| GSE29001 | RORB | 6096 | 206443_at | 0.0420 | 0.8166 | |
| GSE38129 | RORB | 6096 | 206443_at | -0.0773 | 0.2501 | |
| GSE45670 | RORB | 6096 | 231040_at | -1.0653 | 0.0000 | |
| GSE53622 | RORB | 6096 | 153956 | -1.1032 | 0.0000 | |
| GSE53624 | RORB | 6096 | 153956 | -0.5939 | 0.0000 | |
| GSE63941 | RORB | 6096 | 206443_at | -0.4015 | 0.0287 | |
| GSE77861 | RORB | 6096 | 206443_at | -0.0723 | 0.3122 | |
| GSE97050 | RORB | 6096 | A_33_P3235856 | -0.2766 | 0.5733 | |
| SRP133303 | RORB | 6096 | RNAseq | -0.7020 | 0.0332 | |
| SRP159526 | RORB | 6096 | RNAseq | 1.1762 | 0.1195 | |
| SRP193095 | RORB | 6096 | RNAseq | -0.1212 | 0.5731 | |
| SRP219564 | RORB | 6096 | RNAseq | -0.7604 | 0.1520 | |
| TCGA | RORB | 6096 | RNAseq | -0.5762 | 0.2723 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by RORB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RORB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RORB | 6096 | 6 | 10 | 14 | |
| GSE20123 | RORB | 6096 | 6 | 10 | 14 | |
| GSE43470 | RORB | 6096 | 6 | 5 | 32 | |
| GSE46452 | RORB | 6096 | 6 | 14 | 39 | |
| GSE47630 | RORB | 6096 | 1 | 18 | 21 | |
| GSE54993 | RORB | 6096 | 4 | 1 | 65 | |
| GSE54994 | RORB | 6096 | 4 | 13 | 36 | |
| GSE60625 | RORB | 6096 | 0 | 0 | 11 | |
| GSE74703 | RORB | 6096 | 5 | 4 | 27 | |
| GSE74704 | RORB | 6096 | 3 | 7 | 10 | |
| TCGA | RORB | 6096 | 20 | 28 | 48 |
Total number of gains: 61; Total number of losses: 110; Total Number of normals: 317.
Somatic mutations of RORB:
Generating mutation plots.
Highly correlated genes for RORB:
Showing top 20/560 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RORB | KCNJ10 | 0.708435 | 3 | 0 | 3 |
| RORB | RIT2 | 0.704168 | 3 | 0 | 3 |
| RORB | HAND1 | 0.691175 | 4 | 0 | 4 |
| RORB | F7 | 0.691175 | 5 | 0 | 5 |
| RORB | EIF1AY | 0.688974 | 4 | 0 | 3 |
| RORB | COL8A2 | 0.684292 | 3 | 0 | 3 |
| RORB | SEPSECS | 0.683448 | 3 | 0 | 3 |
| RORB | INMT | 0.67662 | 3 | 0 | 3 |
| RORB | ARMC4 | 0.67279 | 4 | 0 | 4 |
| RORB | CDKL5 | 0.672597 | 3 | 0 | 3 |
| RORB | TMEM132C | 0.666696 | 4 | 0 | 3 |
| RORB | S100G | 0.664543 | 4 | 0 | 3 |
| RORB | RERG | 0.660794 | 5 | 0 | 4 |
| RORB | LINC01260 | 0.659083 | 4 | 0 | 4 |
| RORB | ARID5B | 0.6556 | 4 | 0 | 4 |
| RORB | FOXN3-AS2 | 0.651009 | 3 | 0 | 3 |
| RORB | WDTC1 | 0.650599 | 3 | 0 | 3 |
| RORB | CST8 | 0.648744 | 3 | 0 | 3 |
| RORB | APOBR | 0.647613 | 4 | 0 | 4 |
| RORB | PYHIN1 | 0.643518 | 4 | 0 | 4 |
For details and further investigation, click here
