| Full name: Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase | Alias Symbol: SLA/LP|SLA | ||
| Type: protein-coding gene | Cytoband: 4p15.2 | ||
| Entrez ID: 51091 | HGNC ID: HGNC:30605 | Ensembl Gene: ENSG00000109618 | OMIM ID: 613009 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SEPSECS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEPSECS | 51091 | 227982_at | -0.2081 | 0.6076 | |
| GSE26886 | SEPSECS | 51091 | 1569634_at | -0.1267 | 0.2408 | |
| GSE45670 | SEPSECS | 51091 | 227982_at | -0.4252 | 0.0096 | |
| GSE53622 | SEPSECS | 51091 | 83807 | -0.0282 | 0.7630 | |
| GSE53624 | SEPSECS | 51091 | 83807 | 0.1619 | 0.0260 | |
| GSE63941 | SEPSECS | 51091 | 227982_at | -0.0218 | 0.9726 | |
| GSE77861 | SEPSECS | 51091 | 1569634_at | 0.0035 | 0.9842 | |
| GSE97050 | SEPSECS | 51091 | A_23_P167201 | -0.0389 | 0.8738 | |
| SRP007169 | SEPSECS | 51091 | RNAseq | -0.6371 | 0.0885 | |
| SRP008496 | SEPSECS | 51091 | RNAseq | -0.4098 | 0.0930 | |
| SRP064894 | SEPSECS | 51091 | RNAseq | -0.0507 | 0.8094 | |
| SRP133303 | SEPSECS | 51091 | RNAseq | -0.2035 | 0.1900 | |
| SRP159526 | SEPSECS | 51091 | RNAseq | -0.3705 | 0.0403 | |
| SRP193095 | SEPSECS | 51091 | RNAseq | -0.6659 | 0.0000 | |
| SRP219564 | SEPSECS | 51091 | RNAseq | -0.2501 | 0.5469 | |
| TCGA | SEPSECS | 51091 | RNAseq | -0.2988 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SEPSECS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEPSECS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEPSECS | 51091 | 0 | 18 | 12 | |
| GSE20123 | SEPSECS | 51091 | 0 | 17 | 13 | |
| GSE43470 | SEPSECS | 51091 | 0 | 15 | 28 | |
| GSE46452 | SEPSECS | 51091 | 1 | 36 | 22 | |
| GSE47630 | SEPSECS | 51091 | 1 | 19 | 20 | |
| GSE54993 | SEPSECS | 51091 | 10 | 0 | 60 | |
| GSE54994 | SEPSECS | 51091 | 4 | 11 | 38 | |
| GSE60625 | SEPSECS | 51091 | 0 | 0 | 11 | |
| GSE74703 | SEPSECS | 51091 | 0 | 13 | 23 | |
| GSE74704 | SEPSECS | 51091 | 0 | 11 | 9 | |
| TCGA | SEPSECS | 51091 | 11 | 47 | 38 |
Total number of gains: 27; Total number of losses: 187; Total Number of normals: 274.
Somatic mutations of SEPSECS:
Generating mutation plots.
Highly correlated genes for SEPSECS:
Showing top 20/70 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEPSECS | CREG1 | 0.753704 | 3 | 0 | 3 |
| SEPSECS | RNF145 | 0.743451 | 3 | 0 | 3 |
| SEPSECS | POLK | 0.720992 | 3 | 0 | 3 |
| SEPSECS | ABHD4 | 0.705199 | 4 | 0 | 4 |
| SEPSECS | IGBP1 | 0.699346 | 3 | 0 | 3 |
| SEPSECS | ROR1 | 0.690983 | 3 | 0 | 3 |
| SEPSECS | PPP2R2C | 0.687631 | 3 | 0 | 3 |
| SEPSECS | LPAR6 | 0.686933 | 3 | 0 | 3 |
| SEPSECS | RORB | 0.683448 | 3 | 0 | 3 |
| SEPSECS | ARL6IP5 | 0.68178 | 3 | 0 | 3 |
| SEPSECS | SYNE1 | 0.666751 | 3 | 0 | 3 |
| SEPSECS | DOCK8 | 0.665692 | 3 | 0 | 3 |
| SEPSECS | CXCL12 | 0.66505 | 3 | 0 | 3 |
| SEPSECS | MOXD1 | 0.66388 | 3 | 0 | 3 |
| SEPSECS | ADARB2-AS1 | 0.662064 | 3 | 0 | 3 |
| SEPSECS | DMXL1 | 0.660977 | 3 | 0 | 3 |
| SEPSECS | ZNF462 | 0.655189 | 4 | 0 | 3 |
| SEPSECS | IGDCC4 | 0.654463 | 3 | 0 | 3 |
| SEPSECS | ABLIM2 | 0.652662 | 4 | 0 | 3 |
| SEPSECS | RPL9 | 0.650998 | 3 | 0 | 3 |
For details and further investigation, click here
