| Full name: ribosomal protein L18 | Alias Symbol: L18 | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 6141 | HGNC ID: HGNC:10310 | Ensembl Gene: ENSG00000063177 | OMIM ID: 604179 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RPL18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPL18 | 6141 | 200022_at | -0.0940 | 0.7231 | |
| GSE20347 | RPL18 | 6141 | 200022_at | -0.2226 | 0.0033 | |
| GSE23400 | RPL18 | 6141 | 200022_at | -0.2198 | 0.0101 | |
| GSE26886 | RPL18 | 6141 | 200022_at | 0.0922 | 0.7065 | |
| GSE29001 | RPL18 | 6141 | 200022_at | -0.5799 | 0.0855 | |
| GSE38129 | RPL18 | 6141 | 200022_at | -0.0258 | 0.7932 | |
| GSE45670 | RPL18 | 6141 | 200022_at | -0.2743 | 0.0016 | |
| GSE53622 | RPL18 | 6141 | 2302 | -0.3609 | 0.0000 | |
| GSE53624 | RPL18 | 6141 | 2302 | -0.1615 | 0.0011 | |
| GSE63941 | RPL18 | 6141 | 200022_at | 1.0537 | 0.0000 | |
| GSE77861 | RPL18 | 6141 | 200022_at | -0.2251 | 0.3408 | |
| GSE97050 | RPL18 | 6141 | A_23_P142146 | -0.4191 | 0.2515 | |
| SRP007169 | RPL18 | 6141 | RNAseq | -1.5728 | 0.0000 | |
| SRP008496 | RPL18 | 6141 | RNAseq | -1.5796 | 0.0000 | |
| SRP064894 | RPL18 | 6141 | RNAseq | -0.1861 | 0.6251 | |
| SRP133303 | RPL18 | 6141 | RNAseq | -0.7284 | 0.0013 | |
| SRP159526 | RPL18 | 6141 | RNAseq | -0.6799 | 0.0000 | |
| SRP193095 | RPL18 | 6141 | RNAseq | -1.0359 | 0.0000 | |
| SRP219564 | RPL18 | 6141 | RNAseq | -0.5005 | 0.1064 | |
| TCGA | RPL18 | 6141 | RNAseq | 0.0251 | 0.5842 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by RPL18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPL18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPL18 | 6141 | 4 | 4 | 22 | |
| GSE20123 | RPL18 | 6141 | 4 | 3 | 23 | |
| GSE43470 | RPL18 | 6141 | 4 | 10 | 29 | |
| GSE46452 | RPL18 | 6141 | 45 | 1 | 13 | |
| GSE47630 | RPL18 | 6141 | 8 | 7 | 25 | |
| GSE54993 | RPL18 | 6141 | 17 | 4 | 49 | |
| GSE54994 | RPL18 | 6141 | 4 | 14 | 35 | |
| GSE60625 | RPL18 | 6141 | 9 | 0 | 2 | |
| GSE74703 | RPL18 | 6141 | 4 | 7 | 25 | |
| GSE74704 | RPL18 | 6141 | 4 | 1 | 15 | |
| TCGA | RPL18 | 6141 | 14 | 18 | 64 |
Total number of gains: 117; Total number of losses: 69; Total Number of normals: 302.
Somatic mutations of RPL18:
Generating mutation plots.
Highly correlated genes for RPL18:
Showing top 20/556 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPL18 | RPS5 | 0.796393 | 12 | 0 | 11 |
| RPL18 | VTI1B | 0.766096 | 3 | 0 | 3 |
| RPL18 | NUDT16 | 0.749957 | 3 | 0 | 3 |
| RPL18 | PPP1R11 | 0.749692 | 3 | 0 | 3 |
| RPL18 | USP21 | 0.736315 | 3 | 0 | 3 |
| RPL18 | DHPS | 0.728203 | 3 | 0 | 3 |
| RPL18 | ZNF227 | 0.711133 | 3 | 0 | 3 |
| RPL18 | SYNE2 | 0.710849 | 3 | 0 | 3 |
| RPL18 | CCDC124 | 0.701271 | 3 | 0 | 3 |
| RPL18 | ZFPL1 | 0.696323 | 3 | 0 | 3 |
| RPL18 | RAC1 | 0.695567 | 4 | 0 | 4 |
| RPL18 | NDUFV1 | 0.694806 | 4 | 0 | 4 |
| RPL18 | ADAM11 | 0.684851 | 3 | 0 | 3 |
| RPL18 | RPS9 | 0.683813 | 13 | 0 | 11 |
| RPL18 | TMEM185A | 0.683772 | 3 | 0 | 3 |
| RPL18 | RPL29 | 0.683768 | 12 | 0 | 12 |
| RPL18 | DDA1 | 0.68181 | 3 | 0 | 3 |
| RPL18 | BEX5 | 0.6796 | 3 | 0 | 3 |
| RPL18 | HAX1 | 0.679311 | 4 | 0 | 4 |
| RPL18 | EEFSEC | 0.677786 | 3 | 0 | 3 |
For details and further investigation, click here
