| Full name: ADAM metallopeptidase domain 11 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 4185 | HGNC ID: HGNC:189 | Ensembl Gene: ENSG00000073670 | OMIM ID: 155120 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAM11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAM11 | 4185 | 207880_at | -0.1902 | 0.5295 | |
| GSE20347 | ADAM11 | 4185 | 207880_at | 0.0201 | 0.8836 | |
| GSE23400 | ADAM11 | 4185 | 207880_at | -0.2201 | 0.0000 | |
| GSE26886 | ADAM11 | 4185 | 239837_at | 0.1032 | 0.4349 | |
| GSE29001 | ADAM11 | 4185 | 207880_at | -0.2308 | 0.1547 | |
| GSE38129 | ADAM11 | 4185 | 207880_at | -0.1778 | 0.1146 | |
| GSE45670 | ADAM11 | 4185 | 207880_at | -0.0071 | 0.9612 | |
| GSE53622 | ADAM11 | 4185 | 92390 | 0.2603 | 0.0075 | |
| GSE53624 | ADAM11 | 4185 | 92390 | 0.3358 | 0.0039 | |
| GSE63941 | ADAM11 | 4185 | 207880_at | 0.3537 | 0.0247 | |
| GSE77861 | ADAM11 | 4185 | 239837_at | -0.1554 | 0.2335 | |
| GSE97050 | ADAM11 | 4185 | A_33_P3386775 | -0.0578 | 0.8085 | |
| SRP133303 | ADAM11 | 4185 | RNAseq | -0.7694 | 0.0551 | |
| SRP219564 | ADAM11 | 4185 | RNAseq | 0.0337 | 0.9533 | |
| TCGA | ADAM11 | 4185 | RNAseq | 0.2422 | 0.4684 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ADAM11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAM11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAM11 | 4185 | 6 | 2 | 22 | |
| GSE20123 | ADAM11 | 4185 | 6 | 2 | 22 | |
| GSE43470 | ADAM11 | 4185 | 1 | 2 | 40 | |
| GSE46452 | ADAM11 | 4185 | 32 | 0 | 27 | |
| GSE47630 | ADAM11 | 4185 | 9 | 0 | 31 | |
| GSE54993 | ADAM11 | 4185 | 3 | 4 | 63 | |
| GSE54994 | ADAM11 | 4185 | 8 | 5 | 40 | |
| GSE60625 | ADAM11 | 4185 | 4 | 0 | 7 | |
| GSE74703 | ADAM11 | 4185 | 1 | 1 | 34 | |
| GSE74704 | ADAM11 | 4185 | 4 | 1 | 15 | |
| TCGA | ADAM11 | 4185 | 27 | 6 | 63 |
Total number of gains: 101; Total number of losses: 23; Total Number of normals: 364.
Somatic mutations of ADAM11:
Generating mutation plots.
Highly correlated genes for ADAM11:
Showing top 20/1148 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAM11 | LIPF | 0.826025 | 4 | 0 | 4 |
| ADAM11 | GSTT2 | 0.78652 | 3 | 0 | 3 |
| ADAM11 | CBL | 0.772531 | 5 | 0 | 5 |
| ADAM11 | KLF15 | 0.758194 | 4 | 0 | 4 |
| ADAM11 | FAM122A | 0.748388 | 3 | 0 | 3 |
| ADAM11 | SEC16B | 0.745184 | 3 | 0 | 3 |
| ADAM11 | ZNF771 | 0.735861 | 5 | 0 | 4 |
| ADAM11 | DCTN2 | 0.73576 | 4 | 0 | 3 |
| ADAM11 | ZNF334 | 0.734749 | 3 | 0 | 3 |
| ADAM11 | OR10H3 | 0.729346 | 4 | 0 | 4 |
| ADAM11 | ITGB3 | 0.727756 | 6 | 0 | 5 |
| ADAM11 | DNAH1 | 0.725304 | 4 | 0 | 4 |
| ADAM11 | PHLDB1 | 0.725055 | 7 | 0 | 5 |
| ADAM11 | BRINP2 | 0.724877 | 4 | 0 | 4 |
| ADAM11 | RBKS | 0.722422 | 3 | 0 | 3 |
| ADAM11 | HHLA1 | 0.720844 | 9 | 0 | 8 |
| ADAM11 | ELFN1 | 0.720389 | 4 | 0 | 3 |
| ADAM11 | RSPH3 | 0.717797 | 3 | 0 | 3 |
| ADAM11 | SEC22B | 0.716875 | 3 | 0 | 3 |
| ADAM11 | TBC1D25 | 0.71193 | 3 | 0 | 3 |
For details and further investigation, click here
