RAC1

 

Full name: Rac family small GTPase 1 Alias Symbol: TC-25|p21-Rac1|Rac-1
Type: protein-coding gene Cytoband: 7p22.1
Entrez ID: 5879 HGNC ID: HGNC:9801 Ensembl Gene: ENSG00000136238 OMIM ID: 602048
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 250/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

RAC1 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04520Adherens junction
hsa04620Toll-like receptor signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05100Bacterial invasion of epithelial cells
hsa05131Shigellosis
hsa05132Salmonella infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05210Colorectal cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05231Choline metabolism in cancer

 

Expression of RAC1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RAC1 5879 208640_at -0.2627 0.6479
GSE20347 RAC1 5879 208641_s_at -0.2369 0.0558
GSE23400 RAC1 5879 208640_at -0.2406 0.0001
GSE26886 RAC1 5879 208640_at -0.7703 0.0004
GSE29001 RAC1 5879 208640_at -0.2947 0.1273
GSE38129 RAC1 5879 208641_s_at 0.0094 0.9510
GSE45670 RAC1 5879 208640_at -0.0510 0.7065
GSE53622 RAC1 5879 160545 -0.4852 0.0000
GSE53624 RAC1 5879 160545 -0.5475 0.0000
GSE63941 RAC1 5879 208641_s_at 0.5121 0.0021
GSE77861 RAC1 5879 208640_at -0.2101 0.0711
GSE97050 RAC1 5879 A_23_P215406 -0.0057 0.9839
SRP007169 RAC1 5879 RNAseq -1.3144 0.0024
SRP008496 RAC1 5879 RNAseq -1.2186 0.0000
SRP064894 RAC1 5879 RNAseq -0.1977 0.3123
SRP133303 RAC1 5879 RNAseq -0.0340 0.8565
SRP159526 RAC1 5879 RNAseq -0.6676 0.0005
SRP193095 RAC1 5879 RNAseq -0.6196 0.0000
SRP219564 RAC1 5879 RNAseq -0.5224 0.0707
TCGA RAC1 5879 RNAseq 0.1184 0.0060

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by RAC1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RAC1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RAC1 5879 14 1 15
GSE20123 RAC1 5879 14 1 15
GSE43470 RAC1 5879 6 1 36
GSE46452 RAC1 5879 13 1 45
GSE47630 RAC1 5879 9 1 30
GSE54993 RAC1 5879 0 6 64
GSE54994 RAC1 5879 20 1 32
GSE60625 RAC1 5879 0 0 11
GSE74703 RAC1 5879 6 0 30
GSE74704 RAC1 5879 9 0 11
TCGA RAC1 5879 55 5 36

Total number of gains: 146; Total number of losses: 17; Total Number of normals: 325.  

 

Somatic mutations of RAC1:

 

Generating mutation plots.

 

Highly correlated genes for RAC1:

 

Showing top 20/1000 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RAC1ZFPL10.788842303
RAC1RHBDD10.787159303
RAC1COX150.778915303
RAC1SNAP230.747726403
RAC1ZBED50.746472303
RAC1TYSND10.743099404
RAC1TAX1BP30.740845303
RAC1PRPF38A0.736032404
RAC1RNF1810.729481303
RAC1ACTR20.726743403
RAC1VPS250.724522606
RAC1FAM199X0.723721303
RAC1C12orf660.720241303
RAC1GPR1080.717449303
RAC1LINC004790.71543303
RAC1PGM20.714639606
RAC1DNAJB60.713915403
RAC1TXNDC110.707119303
RAC1IMPACT0.706594303
RAC1LPCAT20.705967303

For details and further investigation, click here