| Full name: deoxyhypusine synthase | Alias Symbol: MIG13 | ||
| Type: protein-coding gene | Cytoband: 19p13.13 | ||
| Entrez ID: 1725 | HGNC ID: HGNC:2869 | Ensembl Gene: ENSG00000095059 | OMIM ID: 600944 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DHPS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DHPS | 1725 | 207831_x_at | 0.3438 | 0.4836 | |
| GSE20347 | DHPS | 1725 | 207831_x_at | 0.1073 | 0.2702 | |
| GSE23400 | DHPS | 1725 | 207831_x_at | 0.3110 | 0.0000 | |
| GSE26886 | DHPS | 1725 | 207831_x_at | 0.5138 | 0.0092 | |
| GSE29001 | DHPS | 1725 | 207831_x_at | 0.4823 | 0.0481 | |
| GSE38129 | DHPS | 1725 | 207831_x_at | 0.1658 | 0.1248 | |
| GSE45670 | DHPS | 1725 | 207831_x_at | 0.0863 | 0.5649 | |
| GSE53622 | DHPS | 1725 | 27418 | 0.2014 | 0.0008 | |
| GSE53624 | DHPS | 1725 | 27418 | 0.2975 | 0.0000 | |
| GSE63941 | DHPS | 1725 | 207831_x_at | 1.3738 | 0.0016 | |
| GSE77861 | DHPS | 1725 | 207831_x_at | 0.3567 | 0.0771 | |
| GSE97050 | DHPS | 1725 | A_23_P501887 | -0.2316 | 0.3631 | |
| SRP007169 | DHPS | 1725 | RNAseq | -0.2373 | 0.5277 | |
| SRP008496 | DHPS | 1725 | RNAseq | -0.0636 | 0.7689 | |
| SRP064894 | DHPS | 1725 | RNAseq | 0.6871 | 0.0094 | |
| SRP133303 | DHPS | 1725 | RNAseq | 0.0304 | 0.8630 | |
| SRP159526 | DHPS | 1725 | RNAseq | -0.0242 | 0.8888 | |
| SRP193095 | DHPS | 1725 | RNAseq | 0.1602 | 0.0368 | |
| SRP219564 | DHPS | 1725 | RNAseq | 0.4746 | 0.2870 | |
| TCGA | DHPS | 1725 | RNAseq | 0.0264 | 0.6220 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DHPS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DHPS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DHPS | 1725 | 4 | 2 | 24 | |
| GSE20123 | DHPS | 1725 | 3 | 1 | 26 | |
| GSE43470 | DHPS | 1725 | 2 | 6 | 35 | |
| GSE46452 | DHPS | 1725 | 47 | 1 | 11 | |
| GSE47630 | DHPS | 1725 | 4 | 7 | 29 | |
| GSE54993 | DHPS | 1725 | 16 | 3 | 51 | |
| GSE54994 | DHPS | 1725 | 6 | 13 | 34 | |
| GSE60625 | DHPS | 1725 | 9 | 0 | 2 | |
| GSE74703 | DHPS | 1725 | 2 | 4 | 30 | |
| GSE74704 | DHPS | 1725 | 0 | 1 | 19 | |
| TCGA | DHPS | 1725 | 16 | 13 | 67 |
Total number of gains: 109; Total number of losses: 51; Total Number of normals: 328.
Somatic mutations of DHPS:
Generating mutation plots.
Highly correlated genes for DHPS:
Showing top 20/1038 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DHPS | ATG4C | 0.827201 | 3 | 0 | 3 |
| DHPS | PACS1 | 0.810758 | 3 | 0 | 3 |
| DHPS | KDM4A | 0.802517 | 3 | 0 | 3 |
| DHPS | NUB1 | 0.781715 | 3 | 0 | 3 |
| DHPS | FAM76B | 0.762882 | 3 | 0 | 3 |
| DHPS | GGN | 0.755187 | 3 | 0 | 3 |
| DHPS | TBC1D25 | 0.753964 | 3 | 0 | 3 |
| DHPS | MRPL38 | 0.748583 | 5 | 0 | 5 |
| DHPS | CAMTA1 | 0.74379 | 3 | 0 | 3 |
| DHPS | DZIP3 | 0.738244 | 3 | 0 | 3 |
| DHPS | DMAP1 | 0.73202 | 3 | 0 | 3 |
| DHPS | UBIAD1 | 0.731994 | 4 | 0 | 4 |
| DHPS | RPL18 | 0.728203 | 3 | 0 | 3 |
| DHPS | RSBN1 | 0.723441 | 3 | 0 | 3 |
| DHPS | SCAF1 | 0.723146 | 3 | 0 | 3 |
| DHPS | NTPCR | 0.719127 | 3 | 0 | 3 |
| DHPS | SMARCAD1 | 0.713764 | 3 | 0 | 3 |
| DHPS | KRTCAP2 | 0.708834 | 4 | 0 | 4 |
| DHPS | CHCHD6 | 0.705212 | 6 | 0 | 6 |
| DHPS | HEXA | 0.702684 | 4 | 0 | 4 |
For details and further investigation, click here
