TMEM9

 

Full name: transmembrane protein 9 Alias Symbol: TMEM9A
Type: protein-coding gene Cytoband: 1q32.1
Entrez ID: 252839 HGNC ID: HGNC:18823 Ensembl Gene: ENSG00000116857 OMIM ID: 616877
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of TMEM9:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TMEM9 252839 222988_s_at 0.9881 0.0086
GSE26886 TMEM9 252839 222988_s_at 1.4205 0.0000
GSE45670 TMEM9 252839 222988_s_at 0.6109 0.0031
GSE53622 TMEM9 252839 77127 0.9805 0.0000
GSE53624 TMEM9 252839 37185 0.8573 0.0000
GSE63941 TMEM9 252839 222988_s_at 0.2473 0.5654
GSE77861 TMEM9 252839 222987_s_at 0.5203 0.0060
GSE97050 TMEM9 252839 A_23_P114952 0.1251 0.6941
SRP007169 TMEM9 252839 RNAseq 1.4970 0.0016
SRP008496 TMEM9 252839 RNAseq 1.1374 0.0009
SRP064894 TMEM9 252839 RNAseq 1.1670 0.0005
SRP133303 TMEM9 252839 RNAseq 0.9732 0.0034
SRP159526 TMEM9 252839 RNAseq 1.3929 0.0000
SRP193095 TMEM9 252839 RNAseq 0.7766 0.0000
SRP219564 TMEM9 252839 RNAseq 1.0335 0.0190
TCGA TMEM9 252839 RNAseq 0.0888 0.1275

Upregulated datasets: 6; Downregulated datasets: 0.  

 

Survival by TMEM9 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TMEM9:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TMEM9 252839 12 0 18
GSE20123 TMEM9 252839 12 0 18
GSE43470 TMEM9 252839 6 0 37
GSE46452 TMEM9 252839 3 1 55
GSE47630 TMEM9 252839 14 0 26
GSE54993 TMEM9 252839 0 6 64
GSE54994 TMEM9 252839 15 0 38
GSE60625 TMEM9 252839 0 0 11
GSE74703 TMEM9 252839 6 0 30
GSE74704 TMEM9 252839 5 0 15
TCGA TMEM9 252839 43 4 49

Total number of gains: 116; Total number of losses: 11; Total Number of normals: 361.  

 

Somatic mutations of TMEM9:

 

Generating mutation plots.

 

Highly correlated genes for TMEM9:

 

Showing top 20/595 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TMEM9CTHRC10.771903606
TMEM9IPO90.759523505
TMEM9HOXC90.755395505
TMEM9MFAP20.743624606
TMEM9TBX20.741406303
TMEM9NAT140.740142707
TMEM9RASL11B0.731448403
TMEM9COLGALT10.731369606
TMEM9LRRC8D0.725116606
TMEM9NPW0.721091404
TMEM9FUT10.719999403
TMEM9BID0.714959606
TMEM9APMAP0.711633606
TMEM9MTERF30.711092404
TMEM9SNX100.708421606
TMEM9PCSK1N0.706748303
TMEM9DNAH20.705785303
TMEM9DESI20.704488606
TMEM9ECT20.703856505
TMEM9TMEM1820.702305504

For details and further investigation, click here