| Full name: ribosomal protein S6 | Alias Symbol: S6 | ||
| Type: protein-coding gene | Cytoband: 9p22.1 | ||
| Entrez ID: 6194 | HGNC ID: HGNC:10429 | Ensembl Gene: ENSG00000137154 | OMIM ID: 180460 |
| Drug and gene relationship at DGIdb | |||
RPS6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04066 | HIF-1 signaling pathway | |
| hsa04150 | mTOR signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04910 | Insulin signaling pathway | |
| hsa05205 | Proteoglycans in cancer |
Expression of RPS6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPS6 | 6194 | 209134_s_at | -0.2853 | 0.2931 | |
| GSE20347 | RPS6 | 6194 | 201254_x_at | -0.4279 | 0.0004 | |
| GSE23400 | RPS6 | 6194 | 209134_s_at | -0.1035 | 0.0526 | |
| GSE26886 | RPS6 | 6194 | 201254_x_at | -0.2058 | 0.1328 | |
| GSE29001 | RPS6 | 6194 | 209134_s_at | -0.3557 | 0.1166 | |
| GSE38129 | RPS6 | 6194 | 201254_x_at | -0.2758 | 0.0017 | |
| GSE45670 | RPS6 | 6194 | 209134_s_at | -0.3855 | 0.0020 | |
| GSE53622 | RPS6 | 6194 | 69916 | -0.9736 | 0.0000 | |
| GSE53624 | RPS6 | 6194 | 69916 | -0.4444 | 0.0000 | |
| GSE63941 | RPS6 | 6194 | 209134_s_at | 0.0919 | 0.8000 | |
| GSE77861 | RPS6 | 6194 | 209134_s_at | -0.3631 | 0.0130 | |
| GSE97050 | RPS6 | 6194 | A_23_P123563 | -0.5445 | 0.2092 | |
| SRP007169 | RPS6 | 6194 | RNAseq | -1.3012 | 0.0043 | |
| SRP008496 | RPS6 | 6194 | RNAseq | -1.2506 | 0.0000 | |
| SRP064894 | RPS6 | 6194 | RNAseq | -0.5800 | 0.0478 | |
| SRP133303 | RPS6 | 6194 | RNAseq | -1.0033 | 0.0000 | |
| SRP159526 | RPS6 | 6194 | RNAseq | -1.2998 | 0.0000 | |
| SRP193095 | RPS6 | 6194 | RNAseq | -1.3606 | 0.0000 | |
| SRP219564 | RPS6 | 6194 | RNAseq | -0.6037 | 0.1968 | |
| TCGA | RPS6 | 6194 | RNAseq | -0.0706 | 0.2028 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by RPS6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPS6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPS6 | 6194 | 2 | 16 | 12 | |
| GSE20123 | RPS6 | 6194 | 2 | 16 | 12 | |
| GSE43470 | RPS6 | 6194 | 4 | 11 | 28 | |
| GSE46452 | RPS6 | 6194 | 2 | 23 | 34 | |
| GSE47630 | RPS6 | 6194 | 3 | 27 | 10 | |
| GSE54993 | RPS6 | 6194 | 6 | 2 | 62 | |
| GSE54994 | RPS6 | 6194 | 8 | 17 | 28 | |
| GSE60625 | RPS6 | 6194 | 0 | 0 | 11 | |
| GSE74703 | RPS6 | 6194 | 4 | 8 | 24 | |
| GSE74704 | RPS6 | 6194 | 0 | 13 | 7 | |
| TCGA | RPS6 | 6194 | 12 | 51 | 33 |
Total number of gains: 43; Total number of losses: 184; Total Number of normals: 261.
Somatic mutations of RPS6:
Generating mutation plots.
Highly correlated genes for RPS6:
Showing top 20/583 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPS6 | RPS13 | 0.774661 | 3 | 0 | 3 |
| RPS6 | DUSP13 | 0.725198 | 3 | 0 | 3 |
| RPS6 | PGM5 | 0.724194 | 4 | 0 | 4 |
| RPS6 | RPL29 | 0.712787 | 10 | 0 | 9 |
| RPS6 | RPL3 | 0.699013 | 12 | 0 | 10 |
| RPS6 | BOC | 0.698627 | 4 | 0 | 4 |
| RPS6 | ZADH2 | 0.690492 | 3 | 0 | 3 |
| RPS6 | NFASC | 0.676075 | 3 | 0 | 3 |
| RPS6 | LINC01315 | 0.672549 | 5 | 0 | 5 |
| RPS6 | RPL15 | 0.662198 | 11 | 0 | 9 |
| RPS6 | RBM20 | 0.661365 | 3 | 0 | 3 |
| RPS6 | RRAGA | 0.659257 | 10 | 0 | 10 |
| RPS6 | ITGA9 | 0.655691 | 3 | 0 | 3 |
| RPS6 | RPL32 | 0.655479 | 11 | 0 | 9 |
| RPS6 | DCAF10 | 0.650022 | 6 | 0 | 5 |
| RPS6 | BTF3 | 0.649614 | 9 | 0 | 9 |
| RPS6 | EIF4B | 0.649528 | 10 | 0 | 9 |
| RPS6 | SAMD5 | 0.645733 | 5 | 0 | 4 |
| RPS6 | ICA1L | 0.645061 | 3 | 0 | 3 |
| RPS6 | CSNK2B | 0.643325 | 4 | 0 | 4 |
For details and further investigation, click here
