| Full name: ribosomal protein L3 | Alias Symbol: L3 | ||
| Type: protein-coding gene | Cytoband: 22q13.1 | ||
| Entrez ID: 6122 | HGNC ID: HGNC:10332 | Ensembl Gene: ENSG00000100316 | OMIM ID: 604163 |
| Drug and gene relationship at DGIdb | |||
Expression of RPL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPL3 | 6122 | 215963_x_at | -0.2650 | 0.2385 | |
| GSE20347 | RPL3 | 6122 | 215963_x_at | -0.4064 | 0.0000 | |
| GSE23400 | RPL3 | 6122 | 215963_x_at | -0.2243 | 0.0000 | |
| GSE26886 | RPL3 | 6122 | 215963_x_at | -0.0900 | 0.4912 | |
| GSE29001 | RPL3 | 6122 | 215963_x_at | -0.6459 | 0.0609 | |
| GSE38129 | RPL3 | 6122 | 215963_x_at | -0.3559 | 0.0000 | |
| GSE45670 | RPL3 | 6122 | 215963_x_at | -0.4235 | 0.0000 | |
| GSE53622 | RPL3 | 6122 | 100210 | -0.4674 | 0.0000 | |
| GSE53624 | RPL3 | 6122 | 100210 | -0.2166 | 0.0000 | |
| GSE63941 | RPL3 | 6122 | 215963_x_at | -0.1101 | 0.6188 | |
| GSE77861 | RPL3 | 6122 | 215963_x_at | -0.3044 | 0.2219 | |
| GSE97050 | RPL3 | 6122 | A_23_P68942 | -0.2551 | 0.3649 | |
| SRP007169 | RPL3 | 6122 | RNAseq | -1.6158 | 0.0000 | |
| SRP008496 | RPL3 | 6122 | RNAseq | -1.5385 | 0.0000 | |
| SRP064894 | RPL3 | 6122 | RNAseq | -0.3163 | 0.3279 | |
| SRP133303 | RPL3 | 6122 | RNAseq | -1.1487 | 0.0000 | |
| SRP159526 | RPL3 | 6122 | RNAseq | -0.9640 | 0.0000 | |
| SRP193095 | RPL3 | 6122 | RNAseq | -1.2792 | 0.0000 | |
| SRP219564 | RPL3 | 6122 | RNAseq | -0.5905 | 0.0573 | |
| TCGA | RPL3 | 6122 | RNAseq | -0.1463 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by RPL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPL3 | 6122 | 6 | 5 | 19 | |
| GSE20123 | RPL3 | 6122 | 6 | 4 | 20 | |
| GSE43470 | RPL3 | 6122 | 5 | 6 | 32 | |
| GSE46452 | RPL3 | 6122 | 32 | 2 | 25 | |
| GSE47630 | RPL3 | 6122 | 9 | 4 | 27 | |
| GSE54993 | RPL3 | 6122 | 4 | 5 | 61 | |
| GSE54994 | RPL3 | 6122 | 10 | 7 | 36 | |
| GSE60625 | RPL3 | 6122 | 5 | 0 | 6 | |
| GSE74703 | RPL3 | 6122 | 5 | 4 | 27 | |
| GSE74704 | RPL3 | 6122 | 3 | 2 | 15 | |
| TCGA | RPL3 | 6122 | 27 | 15 | 54 |
Total number of gains: 112; Total number of losses: 54; Total Number of normals: 322.
Somatic mutations of RPL3:
Generating mutation plots.
Highly correlated genes for RPL3:
Showing top 20/402 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPL3 | ZMYND11 | 0.755933 | 3 | 0 | 3 |
| RPL3 | CNTN4 | 0.751414 | 3 | 0 | 3 |
| RPL3 | RPL15 | 0.746237 | 10 | 0 | 9 |
| RPL3 | ITGA9 | 0.738334 | 3 | 0 | 3 |
| RPL3 | PTGIS | 0.735923 | 4 | 0 | 3 |
| RPL3 | EEF1A1 | 0.715446 | 8 | 0 | 7 |
| RPL3 | ANGPTL1 | 0.708025 | 3 | 0 | 3 |
| RPL3 | CASQ2 | 0.707814 | 3 | 0 | 3 |
| RPL3 | EIF4B | 0.702394 | 9 | 0 | 8 |
| RPL3 | RPS6 | 0.699013 | 12 | 0 | 10 |
| RPL3 | RPL10A | 0.697583 | 11 | 0 | 10 |
| RPL3 | RPS13 | 0.689366 | 3 | 0 | 3 |
| RPL3 | RPS9 | 0.688953 | 12 | 0 | 10 |
| RPL3 | RPLP0 | 0.686959 | 9 | 0 | 8 |
| RPL3 | FBXL7 | 0.686267 | 4 | 0 | 4 |
| RPL3 | TCEAL2 | 0.682628 | 4 | 0 | 3 |
| RPL3 | ICA1L | 0.673353 | 3 | 0 | 3 |
| RPL3 | RPS5 | 0.665922 | 10 | 0 | 7 |
| RPL3 | RPS3A | 0.665361 | 3 | 0 | 3 |
| RPL3 | RPL6 | 0.665313 | 11 | 0 | 9 |
For details and further investigation, click here
