| Full name: retinoid X receptor alpha | Alias Symbol: NR2B1 | ||
| Type: protein-coding gene | Cytoband: 9q34.2 | ||
| Entrez ID: 6256 | HGNC ID: HGNC:10477 | Ensembl Gene: ENSG00000186350 | OMIM ID: 180245 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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RXRA involved pathways:
Expression of RXRA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RXRA | 6256 | 202449_s_at | 0.2511 | 0.5589 | |
| GSE20347 | RXRA | 6256 | 202449_s_at | -0.4666 | 0.0257 | |
| GSE23400 | RXRA | 6256 | 202449_s_at | -0.1025 | 0.1922 | |
| GSE26886 | RXRA | 6256 | 202449_s_at | -0.6299 | 0.0061 | |
| GSE29001 | RXRA | 6256 | 202449_s_at | -0.2847 | 0.3018 | |
| GSE38129 | RXRA | 6256 | 202449_s_at | -0.4100 | 0.0087 | |
| GSE45670 | RXRA | 6256 | 202449_s_at | -0.0764 | 0.6298 | |
| GSE63941 | RXRA | 6256 | 202449_s_at | 0.2888 | 0.6031 | |
| GSE77861 | RXRA | 6256 | 202449_s_at | -0.0712 | 0.7483 | |
| GSE97050 | RXRA | 6256 | A_23_P423197 | -1.0126 | 0.0465 | |
| SRP007169 | RXRA | 6256 | RNAseq | -1.4410 | 0.0096 | |
| SRP008496 | RXRA | 6256 | RNAseq | -1.3837 | 0.0002 | |
| SRP064894 | RXRA | 6256 | RNAseq | -0.4644 | 0.0085 | |
| SRP133303 | RXRA | 6256 | RNAseq | -0.4787 | 0.1142 | |
| SRP159526 | RXRA | 6256 | RNAseq | -0.5465 | 0.0979 | |
| SRP193095 | RXRA | 6256 | RNAseq | -0.3373 | 0.0473 | |
| SRP219564 | RXRA | 6256 | RNAseq | -0.3418 | 0.3439 | |
| TCGA | RXRA | 6256 | RNAseq | 0.0107 | 0.8553 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by RXRA expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of RXRA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RXRA | 6256 | 4 | 7 | 19 | |
| GSE20123 | RXRA | 6256 | 4 | 7 | 19 | |
| GSE43470 | RXRA | 6256 | 4 | 7 | 32 | |
| GSE46452 | RXRA | 6256 | 6 | 13 | 40 | |
| GSE47630 | RXRA | 6256 | 6 | 15 | 19 | |
| GSE54993 | RXRA | 6256 | 3 | 3 | 64 | |
| GSE54994 | RXRA | 6256 | 12 | 9 | 32 | |
| GSE60625 | RXRA | 6256 | 0 | 0 | 11 | |
| GSE74703 | RXRA | 6256 | 4 | 5 | 27 | |
| GSE74704 | RXRA | 6256 | 2 | 5 | 13 | |
| TCGA | RXRA | 6256 | 28 | 26 | 42 |
Total number of gains: 73; Total number of losses: 97; Total Number of normals: 318.
Somatic mutations of RXRA:
Generating mutation plots.
Highly correlated genes for RXRA:
Showing top 20/468 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RXRA | CPEB4 | 0.770678 | 3 | 0 | 3 |
| RXRA | TOR1AIP2 | 0.736008 | 3 | 0 | 3 |
| RXRA | GK5 | 0.731774 | 3 | 0 | 3 |
| RXRA | XRN1 | 0.724459 | 3 | 0 | 3 |
| RXRA | ATP6V1A | 0.718852 | 4 | 0 | 4 |
| RXRA | MID2 | 0.717819 | 4 | 0 | 4 |
| RXRA | RWDD2B | 0.716112 | 3 | 0 | 3 |
| RXRA | TNRC6A | 0.706477 | 3 | 0 | 3 |
| RXRA | SUGP1 | 0.7015 | 3 | 0 | 3 |
| RXRA | NDUFS2 | 0.700627 | 3 | 0 | 3 |
| RXRA | ARHGAP17 | 0.69558 | 4 | 0 | 3 |
| RXRA | HMGN1 | 0.689743 | 3 | 0 | 3 |
| RXRA | MPP7 | 0.688176 | 3 | 0 | 3 |
| RXRA | MLLT6 | 0.682428 | 3 | 0 | 3 |
| RXRA | WDR37 | 0.681554 | 4 | 0 | 3 |
| RXRA | OXNAD1 | 0.678418 | 3 | 0 | 3 |
| RXRA | ALG14 | 0.676919 | 3 | 0 | 3 |
| RXRA | SRP68 | 0.676045 | 3 | 0 | 3 |
| RXRA | ERCC6 | 0.675554 | 3 | 0 | 3 |
| RXRA | KCTD2 | 0.673278 | 4 | 0 | 3 |
For details and further investigation, click here
