| Full name: sacsin molecular chaperone | Alias Symbol: ARSACS|KIAA0730|DKFZp686B15167|DNAJC29|SPAX6|PPP1R138 | ||
| Type: protein-coding gene | Cytoband: 13q12.12 | ||
| Entrez ID: 26278 | HGNC ID: HGNC:10519 | Ensembl Gene: ENSG00000151835 | OMIM ID: 604490 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SACS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SACS | 26278 | 213262_at | -0.3092 | 0.7029 | |
| GSE20347 | SACS | 26278 | 213262_at | 0.6511 | 0.0338 | |
| GSE23400 | SACS | 26278 | 213262_at | 0.1593 | 0.2197 | |
| GSE26886 | SACS | 26278 | 213262_at | 1.4732 | 0.0005 | |
| GSE29001 | SACS | 26278 | 213262_at | 0.4192 | 0.2716 | |
| GSE38129 | SACS | 26278 | 213262_at | 0.3235 | 0.2748 | |
| GSE45670 | SACS | 26278 | 213262_at | -0.3327 | 0.4325 | |
| GSE53622 | SACS | 26278 | 24031 | 0.1746 | 0.1648 | |
| GSE53624 | SACS | 26278 | 33209 | 0.5398 | 0.0000 | |
| GSE63941 | SACS | 26278 | 213262_at | -3.0891 | 0.0092 | |
| GSE77861 | SACS | 26278 | 213262_at | 0.9110 | 0.0782 | |
| GSE97050 | SACS | 26278 | A_33_P3405500 | -0.4285 | 0.1717 | |
| SRP007169 | SACS | 26278 | RNAseq | 1.5696 | 0.0003 | |
| SRP008496 | SACS | 26278 | RNAseq | 1.7166 | 0.0000 | |
| SRP064894 | SACS | 26278 | RNAseq | 0.1374 | 0.6695 | |
| SRP133303 | SACS | 26278 | RNAseq | 0.3494 | 0.2031 | |
| SRP159526 | SACS | 26278 | RNAseq | -0.2706 | 0.3158 | |
| SRP193095 | SACS | 26278 | RNAseq | 0.8924 | 0.0000 | |
| SRP219564 | SACS | 26278 | RNAseq | -0.0599 | 0.9303 | |
| TCGA | SACS | 26278 | RNAseq | -0.0391 | 0.6419 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by SACS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SACS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SACS | 26278 | 1 | 13 | 16 | |
| GSE20123 | SACS | 26278 | 1 | 12 | 17 | |
| GSE43470 | SACS | 26278 | 2 | 13 | 28 | |
| GSE46452 | SACS | 26278 | 0 | 33 | 26 | |
| GSE47630 | SACS | 26278 | 3 | 26 | 11 | |
| GSE54993 | SACS | 26278 | 11 | 2 | 57 | |
| GSE54994 | SACS | 26278 | 1 | 13 | 39 | |
| GSE60625 | SACS | 26278 | 0 | 3 | 8 | |
| GSE74703 | SACS | 26278 | 2 | 10 | 24 | |
| GSE74704 | SACS | 26278 | 0 | 10 | 10 | |
| TCGA | SACS | 26278 | 7 | 44 | 45 |
Total number of gains: 28; Total number of losses: 179; Total Number of normals: 281.
Somatic mutations of SACS:
Generating mutation plots.
Highly correlated genes for SACS:
Showing top 20/1102 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SACS | PRICKLE2 | 0.836828 | 3 | 0 | 3 |
| SACS | KCNE3 | 0.771563 | 3 | 0 | 3 |
| SACS | EP400 | 0.751678 | 3 | 0 | 3 |
| SACS | RBM41 | 0.750085 | 3 | 0 | 3 |
| SACS | SLCO3A1 | 0.733881 | 3 | 0 | 3 |
| SACS | SLC25A33 | 0.731794 | 3 | 0 | 3 |
| SACS | GDPD1 | 0.722417 | 3 | 0 | 3 |
| SACS | LRRC34 | 0.717733 | 3 | 0 | 3 |
| SACS | KLHL42 | 0.717048 | 6 | 0 | 6 |
| SACS | BAG2 | 0.715423 | 11 | 0 | 10 |
| SACS | NHS | 0.707205 | 3 | 0 | 3 |
| SACS | MEOX2 | 0.705355 | 4 | 0 | 4 |
| SACS | LAMC1 | 0.703985 | 13 | 0 | 13 |
| SACS | WIPF3 | 0.703878 | 3 | 0 | 3 |
| SACS | DHRSX | 0.703575 | 4 | 0 | 3 |
| SACS | ACSS3 | 0.702997 | 3 | 0 | 3 |
| SACS | ERVW-1 | 0.70286 | 4 | 0 | 4 |
| SACS | CLMP | 0.702112 | 6 | 0 | 5 |
| SACS | LYSMD2 | 0.700436 | 3 | 0 | 3 |
| SACS | ZYG11B | 0.699957 | 3 | 0 | 3 |
For details and further investigation, click here
