| Full name: seryl-tRNA synthetase 2, mitochondrial | Alias Symbol: FLJ20450|mtSerRS|SerRSmt|SARS|SERS|SYS | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 54938 | HGNC ID: HGNC:17697 | Ensembl Gene: ENSG00000104835 | OMIM ID: 612804 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SARS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SARS2 | 54938 | 218702_at | 0.3328 | 0.2669 | |
| GSE20347 | SARS2 | 54938 | 218702_at | 0.1624 | 0.3867 | |
| GSE23400 | SARS2 | 54938 | 218702_at | 0.1538 | 0.0065 | |
| GSE26886 | SARS2 | 54938 | 218702_at | 0.1365 | 0.5471 | |
| GSE29001 | SARS2 | 54938 | 218702_at | 0.0728 | 0.8134 | |
| GSE38129 | SARS2 | 54938 | 218702_at | 0.2660 | 0.0464 | |
| GSE45670 | SARS2 | 54938 | 218702_at | 0.2083 | 0.0777 | |
| GSE53622 | SARS2 | 54938 | 17332 | 0.1511 | 0.2820 | |
| GSE53624 | SARS2 | 54938 | 17332 | 0.4751 | 0.0000 | |
| GSE63941 | SARS2 | 54938 | 218702_at | 0.6462 | 0.0723 | |
| GSE77861 | SARS2 | 54938 | 218702_at | 0.1399 | 0.6185 | |
| GSE97050 | SARS2 | 54938 | A_23_P90484 | 0.2817 | 0.3161 | |
| SRP007169 | SARS2 | 54938 | RNAseq | 0.8948 | 0.1521 | |
| SRP008496 | SARS2 | 54938 | RNAseq | 0.1064 | 0.8200 | |
| SRP064894 | SARS2 | 54938 | RNAseq | 0.8488 | 0.0009 | |
| SRP133303 | SARS2 | 54938 | RNAseq | 0.0531 | 0.7988 | |
| SRP159526 | SARS2 | 54938 | RNAseq | 0.3841 | 0.1556 | |
| SRP193095 | SARS2 | 54938 | RNAseq | 0.0395 | 0.7505 | |
| SRP219564 | SARS2 | 54938 | RNAseq | 0.4487 | 0.2720 | |
| TCGA | SARS2 | 54938 | RNAseq | 0.1084 | 0.0971 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SARS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SARS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SARS2 | 54938 | 7 | 4 | 19 | |
| GSE20123 | SARS2 | 54938 | 7 | 3 | 20 | |
| GSE43470 | SARS2 | 54938 | 4 | 10 | 29 | |
| GSE46452 | SARS2 | 54938 | 47 | 2 | 10 | |
| GSE47630 | SARS2 | 54938 | 9 | 5 | 26 | |
| GSE54993 | SARS2 | 54938 | 17 | 3 | 50 | |
| GSE54994 | SARS2 | 54938 | 6 | 9 | 38 | |
| GSE60625 | SARS2 | 54938 | 9 | 0 | 2 | |
| GSE74703 | SARS2 | 54938 | 4 | 6 | 26 | |
| GSE74704 | SARS2 | 54938 | 7 | 1 | 12 | |
| TCGA | SARS2 | 54938 | 14 | 16 | 66 |
Total number of gains: 131; Total number of losses: 59; Total Number of normals: 298.
Somatic mutations of SARS2:
Generating mutation plots.
Highly correlated genes for SARS2:
Showing top 20/472 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SARS2 | ADAM15 | 0.830447 | 3 | 0 | 3 |
| SARS2 | ZFYVE27 | 0.827851 | 3 | 0 | 3 |
| SARS2 | ACBD6 | 0.77489 | 3 | 0 | 3 |
| SARS2 | SSBP4 | 0.774831 | 3 | 0 | 3 |
| SARS2 | C12orf45 | 0.764923 | 3 | 0 | 3 |
| SARS2 | NONO | 0.737954 | 3 | 0 | 3 |
| SARS2 | NUDT19 | 0.732407 | 4 | 0 | 3 |
| SARS2 | AKT1S1 | 0.729628 | 4 | 0 | 4 |
| SARS2 | PLXNA2 | 0.722324 | 3 | 0 | 3 |
| SARS2 | XXYLT1 | 0.7221 | 3 | 0 | 3 |
| SARS2 | ZNF124 | 0.71359 | 4 | 0 | 3 |
| SARS2 | DAZAP1 | 0.713212 | 4 | 0 | 3 |
| SARS2 | RRP36 | 0.709868 | 4 | 0 | 4 |
| SARS2 | TMEM185B | 0.709612 | 3 | 0 | 3 |
| SARS2 | ZNF286A | 0.704256 | 4 | 0 | 4 |
| SARS2 | HYOU1 | 0.704191 | 4 | 0 | 3 |
| SARS2 | PDCD2L | 0.702559 | 5 | 0 | 5 |
| SARS2 | ZFYVE9 | 0.702191 | 3 | 0 | 3 |
| SARS2 | GNA11 | 0.700585 | 3 | 0 | 3 |
| SARS2 | FLVCR1 | 0.700276 | 4 | 0 | 3 |
For details and further investigation, click here
