| Full name: AKT1 substrate 1 | Alias Symbol: PRAS40|MGC2865|Lobe | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 84335 | HGNC ID: HGNC:28426 | Ensembl Gene: ENSG00000204673 | OMIM ID: 610221 |
| Drug and gene relationship at DGIdb | |||
AKT1S1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway | |
| hsa04152 | AMPK signaling pathway | |
| hsa04211 | Longevity regulating pathway - mammal | |
| hsa04213 | Longevity regulating pathway - multiple species |
Expression of AKT1S1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKT1S1 | 84335 | 224982_at | 0.4107 | 0.4726 | |
| GSE26886 | AKT1S1 | 84335 | 224982_at | -0.8923 | 0.0013 | |
| GSE45670 | AKT1S1 | 84335 | 224982_at | 0.3009 | 0.0467 | |
| GSE53622 | AKT1S1 | 84335 | 33778 | -0.1357 | 0.1616 | |
| GSE53624 | AKT1S1 | 84335 | 33778 | 0.2213 | 0.0018 | |
| GSE63941 | AKT1S1 | 84335 | 224982_at | 0.9155 | 0.0310 | |
| GSE77861 | AKT1S1 | 84335 | 224982_at | 0.0087 | 0.9801 | |
| GSE97050 | AKT1S1 | 84335 | A_33_P3344201 | 0.1391 | 0.6256 | |
| SRP007169 | AKT1S1 | 84335 | RNAseq | -0.0668 | 0.8859 | |
| SRP008496 | AKT1S1 | 84335 | RNAseq | -0.2718 | 0.3821 | |
| SRP064894 | AKT1S1 | 84335 | RNAseq | 0.3207 | 0.2999 | |
| SRP133303 | AKT1S1 | 84335 | RNAseq | -0.0169 | 0.9193 | |
| SRP159526 | AKT1S1 | 84335 | RNAseq | 0.1051 | 0.6637 | |
| SRP193095 | AKT1S1 | 84335 | RNAseq | -0.1842 | 0.3361 | |
| SRP219564 | AKT1S1 | 84335 | RNAseq | -0.0564 | 0.8676 | |
| TCGA | AKT1S1 | 84335 | RNAseq | 0.0340 | 0.4660 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by AKT1S1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AKT1S1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKT1S1 | 84335 | 4 | 4 | 22 | |
| GSE20123 | AKT1S1 | 84335 | 4 | 3 | 23 | |
| GSE43470 | AKT1S1 | 84335 | 5 | 11 | 27 | |
| GSE46452 | AKT1S1 | 84335 | 45 | 1 | 13 | |
| GSE47630 | AKT1S1 | 84335 | 10 | 6 | 24 | |
| GSE54993 | AKT1S1 | 84335 | 17 | 4 | 49 | |
| GSE54994 | AKT1S1 | 84335 | 4 | 14 | 35 | |
| GSE60625 | AKT1S1 | 84335 | 9 | 0 | 2 | |
| GSE74703 | AKT1S1 | 84335 | 5 | 7 | 24 | |
| GSE74704 | AKT1S1 | 84335 | 4 | 1 | 15 | |
| TCGA | AKT1S1 | 84335 | 14 | 18 | 64 |
Total number of gains: 121; Total number of losses: 69; Total Number of normals: 298.
Somatic mutations of AKT1S1:
Generating mutation plots.
Highly correlated genes for AKT1S1:
Showing top 20/433 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKT1S1 | WDR25 | 0.792524 | 3 | 0 | 3 |
| AKT1S1 | ZNF740 | 0.790478 | 3 | 0 | 3 |
| AKT1S1 | STAT6 | 0.788818 | 3 | 0 | 3 |
| AKT1S1 | MLLT1 | 0.785998 | 3 | 0 | 3 |
| AKT1S1 | ELAVL1 | 0.774951 | 3 | 0 | 3 |
| AKT1S1 | TMEM129 | 0.774427 | 3 | 0 | 3 |
| AKT1S1 | LDLRAP1 | 0.770664 | 3 | 0 | 3 |
| AKT1S1 | PHACTR1 | 0.76382 | 3 | 0 | 3 |
| AKT1S1 | AGPAT3 | 0.762951 | 3 | 0 | 3 |
| AKT1S1 | ARF5 | 0.759026 | 4 | 0 | 4 |
| AKT1S1 | STK38 | 0.755482 | 3 | 0 | 3 |
| AKT1S1 | ARPC4 | 0.739203 | 5 | 0 | 4 |
| AKT1S1 | PRR3 | 0.738709 | 3 | 0 | 3 |
| AKT1S1 | LINC00167 | 0.737147 | 3 | 0 | 3 |
| AKT1S1 | TFIP11 | 0.734943 | 3 | 0 | 3 |
| AKT1S1 | HNRNPAB | 0.73362 | 4 | 0 | 3 |
| AKT1S1 | SARS2 | 0.729628 | 4 | 0 | 4 |
| AKT1S1 | SPATA2 | 0.727631 | 3 | 0 | 3 |
| AKT1S1 | CCDC65 | 0.726704 | 3 | 0 | 3 |
| AKT1S1 | DDX3X | 0.725673 | 3 | 0 | 3 |
For details and further investigation, click here
