GNA11

 

Full name: G protein subunit alpha 11 Alias Symbol: FBH|FBH2|FHH2
Type: protein-coding gene Cytoband: 19p13.3
Entrez ID: 2767 HGNC ID: HGNC:4379 Ensembl Gene: ENSG00000088256 OMIM ID: 139313
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

GNA11 involved pathways:

KEGG pathway Description View
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04725Cholinergic synapse
hsa04730Long-term depression
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04925Aldosterone synthesis and secretion
hsa05142Chagas disease (American trypanosomiasis)

 

Expression of GNA11:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNA11 2767 564_at 0.3201 0.4961
GSE20347 GNA11 2767 564_at 0.1364 0.3570
GSE23400 GNA11 2767 213944_x_at -0.1327 0.0220
GSE26886 GNA11 2767 213766_x_at 0.1667 0.2355
GSE29001 GNA11 2767 213766_x_at 0.1709 0.3489
GSE38129 GNA11 2767 564_at 0.0379 0.8448
GSE45670 GNA11 2767 564_at -0.1320 0.2602
GSE53622 GNA11 2767 64136 -0.4784 0.0000
GSE53624 GNA11 2767 64136 -0.1046 0.0332
GSE63941 GNA11 2767 564_at -0.5213 0.1334
GSE77861 GNA11 2767 213944_x_at 0.0253 0.8255
GSE97050 GNA11 2767 A_23_P142289 -0.3873 0.1606
SRP007169 GNA11 2767 RNAseq 0.3019 0.4035
SRP008496 GNA11 2767 RNAseq 0.3737 0.1371
SRP064894 GNA11 2767 RNAseq -0.0164 0.9089
SRP133303 GNA11 2767 RNAseq -0.0882 0.6409
SRP159526 GNA11 2767 RNAseq -0.0950 0.6909
SRP193095 GNA11 2767 RNAseq -0.4014 0.0527
SRP219564 GNA11 2767 RNAseq -0.2426 0.6565
TCGA GNA11 2767 RNAseq -0.2109 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by GNA11 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNA11:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNA11 2767 4 4 22
GSE20123 GNA11 2767 3 4 23
GSE43470 GNA11 2767 1 9 33
GSE46452 GNA11 2767 47 1 11
GSE47630 GNA11 2767 5 7 28
GSE54993 GNA11 2767 16 3 51
GSE54994 GNA11 2767 8 16 29
GSE60625 GNA11 2767 9 0 2
GSE74703 GNA11 2767 1 6 29
GSE74704 GNA11 2767 1 3 16
TCGA GNA11 2767 8 22 66

Total number of gains: 103; Total number of losses: 75; Total Number of normals: 310.  

 

Somatic mutations of GNA11:

 

Generating mutation plots.

 

Highly correlated genes for GNA11:

 

Showing top 20/702 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNA11SUN10.779616303
GNA11NCOA50.779033303
GNA11C2orf880.768757303
GNA11SIPA1L20.768752303
GNA11ZNF518B0.765669303
GNA11RPS6KC10.759259303
GNA11TMEM1810.757172303
GNA11MSL20.74721303
GNA11DMAP10.745942303
GNA11BCL90.743886404
GNA11DCAF160.742199303
GNA11RBM4B0.741582303
GNA11SRSF60.737942303
GNA11TM2D30.735717303
GNA11ZBTB440.735157303
GNA11SLC26A110.73175303
GNA11POLR2B0.729059303
GNA11ZNF4180.728481303
GNA11MRPS260.724898303
GNA11UROS0.72487404

For details and further investigation, click here