SCPEP1

 

Full name: serine carboxypeptidase 1 Alias Symbol: RISC
Type: protein-coding gene Cytoband: 17q22
Entrez ID: 59342 HGNC ID: HGNC:29507 Ensembl Gene: ENSG00000121064 OMIM ID: 
Drug and gene relationship at DGIdb

 

Expression of SCPEP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SCPEP1 59342 218217_at 0.1889 0.7869
GSE20347 SCPEP1 59342 218217_at 0.1745 0.4582
GSE23400 SCPEP1 59342 218217_at 0.1466 0.0722
GSE26886 SCPEP1 59342 218217_at 0.0514 0.9134
GSE29001 SCPEP1 59342 218217_at -0.0151 0.9666
GSE38129 SCPEP1 59342 218217_at 0.3791 0.0181
GSE45670 SCPEP1 59342 218217_at 0.1409 0.5102
GSE53622 SCPEP1 59342 33311 0.4720 0.0000
GSE53624 SCPEP1 59342 33311 0.3002 0.0001
GSE63941 SCPEP1 59342 218217_at -1.3583 0.0496
GSE77861 SCPEP1 59342 218217_at 0.1947 0.5253
GSE97050 SCPEP1 59342 A_23_P152548 0.4669 0.2110
SRP007169 SCPEP1 59342 RNAseq 0.4850 0.3266
SRP008496 SCPEP1 59342 RNAseq 0.6698 0.0476
SRP064894 SCPEP1 59342 RNAseq 0.3645 0.0386
SRP133303 SCPEP1 59342 RNAseq 0.4828 0.0432
SRP159526 SCPEP1 59342 RNAseq 1.0348 0.0002
SRP193095 SCPEP1 59342 RNAseq 0.4070 0.0427
SRP219564 SCPEP1 59342 RNAseq 0.6873 0.0680
TCGA SCPEP1 59342 RNAseq 0.0903 0.2277

Upregulated datasets: 1; Downregulated datasets: 1.  

 

Survival by SCPEP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SCPEP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SCPEP1 59342 5 1 24
GSE20123 SCPEP1 59342 5 1 24
GSE43470 SCPEP1 59342 3 1 39
GSE46452 SCPEP1 59342 32 0 27
GSE47630 SCPEP1 59342 7 1 32
GSE54993 SCPEP1 59342 2 4 64
GSE54994 SCPEP1 59342 8 5 40
GSE60625 SCPEP1 59342 4 0 7
GSE74703 SCPEP1 59342 3 1 32
GSE74704 SCPEP1 59342 4 1 15
TCGA SCPEP1 59342 27 6 63

Total number of gains: 100; Total number of losses: 21; Total Number of normals: 367.  

 

Somatic mutations of SCPEP1:

 

Generating mutation plots.

 

Highly correlated genes for SCPEP1:

 

Showing top 20/136 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SCPEP1SLC10A30.740585303
SCPEP1IMPAD10.680453303
SCPEP1NECAP10.678226303
SCPEP1CAT0.67303303
SCPEP1ATP6V0E10.669442303
SCPEP1DHX300.668409303
SCPEP1EID10.665713303
SCPEP1RAB7B0.656677403
SCPEP1DNAH170.649575403
SCPEP1TFDP20.642235505
SCPEP1ABHD40.641713303
SCPEP1DCTD0.63947403
SCPEP1TMEM180.637035303
SCPEP1ABCG10.636577303
SCPEP1SNF80.635533404
SCPEP1SETD70.634461403
SCPEP1IFITM20.633925303
SCPEP1HDAC30.631544404
SCPEP1CAPRIN10.631441504
SCPEP1RNF1660.629921303

For details and further investigation, click here