| Full name: SNF8 subunit of ESCRT-II | Alias Symbol: EAP30|VPS22|Dot3 | ||
| Type: protein-coding gene | Cytoband: 17q21.32 | ||
| Entrez ID: 11267 | HGNC ID: HGNC:17028 | Ensembl Gene: ENSG00000159210 | OMIM ID: 610904 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SNF8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SNF8 | 11267 | 218391_at | -0.0383 | 0.9201 | |
| GSE20347 | SNF8 | 11267 | 218391_at | -0.1571 | 0.3773 | |
| GSE23400 | SNF8 | 11267 | 218391_at | 0.1479 | 0.0195 | |
| GSE26886 | SNF8 | 11267 | 218391_at | -0.3091 | 0.1413 | |
| GSE29001 | SNF8 | 11267 | 218391_at | 0.1412 | 0.6566 | |
| GSE38129 | SNF8 | 11267 | 218391_at | 0.0702 | 0.6820 | |
| GSE45670 | SNF8 | 11267 | 218391_at | 0.1679 | 0.1621 | |
| GSE53622 | SNF8 | 11267 | 61681 | 0.1070 | 0.1246 | |
| GSE53624 | SNF8 | 11267 | 61681 | 0.3160 | 0.0000 | |
| GSE63941 | SNF8 | 11267 | 218391_at | -0.3045 | 0.3949 | |
| GSE77861 | SNF8 | 11267 | 218391_at | 0.1360 | 0.6093 | |
| GSE97050 | SNF8 | 11267 | A_23_P130064 | 0.0821 | 0.6727 | |
| SRP007169 | SNF8 | 11267 | RNAseq | 0.0099 | 0.9778 | |
| SRP008496 | SNF8 | 11267 | RNAseq | -0.1498 | 0.4905 | |
| SRP064894 | SNF8 | 11267 | RNAseq | 0.6521 | 0.0241 | |
| SRP133303 | SNF8 | 11267 | RNAseq | 0.3437 | 0.0002 | |
| SRP159526 | SNF8 | 11267 | RNAseq | 0.7219 | 0.0002 | |
| SRP193095 | SNF8 | 11267 | RNAseq | 0.0166 | 0.8518 | |
| SRP219564 | SNF8 | 11267 | RNAseq | 0.1701 | 0.5729 | |
| TCGA | SNF8 | 11267 | RNAseq | 0.0468 | 0.3679 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SNF8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SNF8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SNF8 | 11267 | 6 | 2 | 22 | |
| GSE20123 | SNF8 | 11267 | 6 | 2 | 22 | |
| GSE43470 | SNF8 | 11267 | 3 | 2 | 38 | |
| GSE46452 | SNF8 | 11267 | 32 | 0 | 27 | |
| GSE47630 | SNF8 | 11267 | 9 | 0 | 31 | |
| GSE54993 | SNF8 | 11267 | 2 | 4 | 64 | |
| GSE54994 | SNF8 | 11267 | 10 | 6 | 37 | |
| GSE60625 | SNF8 | 11267 | 4 | 0 | 7 | |
| GSE74703 | SNF8 | 11267 | 3 | 2 | 31 | |
| GSE74704 | SNF8 | 11267 | 4 | 1 | 15 | |
| TCGA | SNF8 | 11267 | 26 | 7 | 63 |
Total number of gains: 105; Total number of losses: 26; Total Number of normals: 357.
Somatic mutations of SNF8:
Generating mutation plots.
Highly correlated genes for SNF8:
Showing top 20/389 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SNF8 | C12orf57 | 0.786123 | 3 | 0 | 3 |
| SNF8 | CASC4 | 0.747816 | 3 | 0 | 3 |
| SNF8 | FEZ2 | 0.743878 | 3 | 0 | 3 |
| SNF8 | EFTUD2 | 0.721284 | 4 | 0 | 4 |
| SNF8 | LRRC55 | 0.713857 | 3 | 0 | 3 |
| SNF8 | ANAPC11 | 0.710381 | 4 | 0 | 4 |
| SNF8 | INTS12 | 0.705188 | 3 | 0 | 3 |
| SNF8 | AGK | 0.700656 | 3 | 0 | 3 |
| SNF8 | ASH2L | 0.699218 | 3 | 0 | 3 |
| SNF8 | TMEM107 | 0.696955 | 3 | 0 | 3 |
| SNF8 | MRPL27 | 0.689894 | 7 | 0 | 6 |
| SNF8 | MSL1 | 0.688881 | 4 | 0 | 4 |
| SNF8 | DAD1 | 0.680885 | 6 | 0 | 5 |
| SNF8 | HOXB4 | 0.677749 | 3 | 0 | 3 |
| SNF8 | ZDHHC7 | 0.677561 | 3 | 0 | 3 |
| SNF8 | PCCB | 0.674449 | 5 | 0 | 4 |
| SNF8 | TRA2B | 0.672247 | 3 | 0 | 3 |
| SNF8 | FGFR1OP2 | 0.671168 | 4 | 0 | 3 |
| SNF8 | RINT1 | 0.670658 | 3 | 0 | 3 |
| SNF8 | NECAP1 | 0.669962 | 5 | 0 | 3 |
For details and further investigation, click here
