| Full name: histone deacetylase 3 | Alias Symbol: RPD3|HD3|RPD3-2|KDAC3 | ||
| Type: protein-coding gene | Cytoband: 5q31.3 | ||
| Entrez ID: 8841 | HGNC ID: HGNC:4854 | Ensembl Gene: ENSG00000171720 | OMIM ID: 605166 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of HDAC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HDAC3 | 8841 | 216326_s_at | 0.0960 | 0.8217 | |
| GSE20347 | HDAC3 | 8841 | 216326_s_at | -0.0493 | 0.7886 | |
| GSE23400 | HDAC3 | 8841 | 216326_s_at | 0.0921 | 0.0611 | |
| GSE26886 | HDAC3 | 8841 | 216326_s_at | -0.4065 | 0.0056 | |
| GSE29001 | HDAC3 | 8841 | 216326_s_at | -0.1085 | 0.6789 | |
| GSE38129 | HDAC3 | 8841 | 216326_s_at | 0.0936 | 0.4756 | |
| GSE45670 | HDAC3 | 8841 | 216326_s_at | 0.2166 | 0.1070 | |
| GSE53622 | HDAC3 | 8841 | 128291 | -0.1355 | 0.1217 | |
| GSE53624 | HDAC3 | 8841 | 89092 | -0.1241 | 0.0343 | |
| GSE63941 | HDAC3 | 8841 | 216326_s_at | 0.3895 | 0.2460 | |
| GSE77861 | HDAC3 | 8841 | 216326_s_at | 0.0455 | 0.8252 | |
| GSE97050 | HDAC3 | 8841 | A_33_P3309929 | -0.1355 | 0.5665 | |
| SRP007169 | HDAC3 | 8841 | RNAseq | -0.7890 | 0.0247 | |
| SRP008496 | HDAC3 | 8841 | RNAseq | -0.8555 | 0.0000 | |
| SRP064894 | HDAC3 | 8841 | RNAseq | 0.0308 | 0.8405 | |
| SRP133303 | HDAC3 | 8841 | RNAseq | 0.1649 | 0.4371 | |
| SRP159526 | HDAC3 | 8841 | RNAseq | -0.1421 | 0.5948 | |
| SRP193095 | HDAC3 | 8841 | RNAseq | -0.1041 | 0.2763 | |
| SRP219564 | HDAC3 | 8841 | RNAseq | -0.0830 | 0.7165 | |
| TCGA | HDAC3 | 8841 | RNAseq | 0.0333 | 0.5157 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HDAC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HDAC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HDAC3 | 8841 | 2 | 11 | 17 | |
| GSE20123 | HDAC3 | 8841 | 3 | 11 | 16 | |
| GSE43470 | HDAC3 | 8841 | 2 | 10 | 31 | |
| GSE46452 | HDAC3 | 8841 | 0 | 27 | 32 | |
| GSE47630 | HDAC3 | 8841 | 1 | 19 | 20 | |
| GSE54993 | HDAC3 | 8841 | 9 | 1 | 60 | |
| GSE54994 | HDAC3 | 8841 | 2 | 14 | 37 | |
| GSE60625 | HDAC3 | 8841 | 0 | 0 | 11 | |
| GSE74703 | HDAC3 | 8841 | 2 | 7 | 27 | |
| GSE74704 | HDAC3 | 8841 | 2 | 5 | 13 | |
| TCGA | HDAC3 | 8841 | 3 | 38 | 55 |
Total number of gains: 26; Total number of losses: 143; Total Number of normals: 319.
Somatic mutations of HDAC3:
Generating mutation plots.
Highly correlated genes for HDAC3:
Showing top 20/290 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HDAC3 | CDC42SE2 | 0.82024 | 3 | 0 | 3 |
| HDAC3 | DLD | 0.789867 | 3 | 0 | 3 |
| HDAC3 | MAPKAP1 | 0.789837 | 3 | 0 | 3 |
| HDAC3 | STX18 | 0.788315 | 3 | 0 | 3 |
| HDAC3 | RBM7 | 0.780296 | 3 | 0 | 3 |
| HDAC3 | NDUFA9 | 0.768856 | 3 | 0 | 3 |
| HDAC3 | PHKB | 0.752219 | 3 | 0 | 3 |
| HDAC3 | NDUFS2 | 0.752073 | 3 | 0 | 3 |
| HDAC3 | TRIM23 | 0.746404 | 3 | 0 | 3 |
| HDAC3 | CRNKL1 | 0.738857 | 3 | 0 | 3 |
| HDAC3 | NDUFS1 | 0.738337 | 3 | 0 | 3 |
| HDAC3 | MPHOSPH6 | 0.738163 | 3 | 0 | 3 |
| HDAC3 | BCL2L2 | 0.725791 | 3 | 0 | 3 |
| HDAC3 | CPEB3 | 0.72353 | 3 | 0 | 3 |
| HDAC3 | ARFGEF2 | 0.721662 | 3 | 0 | 3 |
| HDAC3 | FNIP1 | 0.720922 | 3 | 0 | 3 |
| HDAC3 | SCAMP1 | 0.716915 | 3 | 0 | 3 |
| HDAC3 | PARP8 | 0.71688 | 3 | 0 | 3 |
| HDAC3 | HLA-E | 0.715938 | 3 | 0 | 3 |
| HDAC3 | KDELR2 | 0.70582 | 3 | 0 | 3 |
For details and further investigation, click here
