| Full name: SET domain containing 7, histone lysine methyltransferase | Alias Symbol: KIAA1717|SET7|SET7/9|Set9|KMT7 | ||
| Type: protein-coding gene | Cytoband: 4q31.1 | ||
| Entrez ID: 80854 | HGNC ID: HGNC:30412 | Ensembl Gene: ENSG00000145391 | OMIM ID: 606594 |
| Drug and gene relationship at DGIdb | |||
SETD7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway |
Expression of SETD7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SETD7 | 80854 | 224928_at | 0.0835 | 0.8260 | |
| GSE26886 | SETD7 | 80854 | 224928_at | -0.2278 | 0.3395 | |
| GSE45670 | SETD7 | 80854 | 224928_at | -0.2702 | 0.0781 | |
| GSE53622 | SETD7 | 80854 | 26560 | -0.1739 | 0.0896 | |
| GSE53624 | SETD7 | 80854 | 26560 | -0.2354 | 0.0422 | |
| GSE63941 | SETD7 | 80854 | 224928_at | -1.5341 | 0.0011 | |
| GSE77861 | SETD7 | 80854 | 224928_at | -0.0327 | 0.9104 | |
| GSE97050 | SETD7 | 80854 | A_33_P3255229 | 0.2870 | 0.4552 | |
| SRP007169 | SETD7 | 80854 | RNAseq | 0.7292 | 0.0762 | |
| SRP008496 | SETD7 | 80854 | RNAseq | 0.8810 | 0.0023 | |
| SRP064894 | SETD7 | 80854 | RNAseq | -0.1219 | 0.5665 | |
| SRP133303 | SETD7 | 80854 | RNAseq | 0.2416 | 0.2573 | |
| SRP159526 | SETD7 | 80854 | RNAseq | -0.1818 | 0.6625 | |
| SRP193095 | SETD7 | 80854 | RNAseq | 0.2717 | 0.0450 | |
| SRP219564 | SETD7 | 80854 | RNAseq | -0.3849 | 0.2942 | |
| TCGA | SETD7 | 80854 | RNAseq | -0.1775 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SETD7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SETD7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SETD7 | 80854 | 0 | 12 | 18 | |
| GSE20123 | SETD7 | 80854 | 0 | 12 | 18 | |
| GSE43470 | SETD7 | 80854 | 0 | 13 | 30 | |
| GSE46452 | SETD7 | 80854 | 1 | 36 | 22 | |
| GSE47630 | SETD7 | 80854 | 0 | 22 | 18 | |
| GSE54993 | SETD7 | 80854 | 10 | 0 | 60 | |
| GSE54994 | SETD7 | 80854 | 2 | 11 | 40 | |
| GSE60625 | SETD7 | 80854 | 0 | 1 | 10 | |
| GSE74703 | SETD7 | 80854 | 0 | 11 | 25 | |
| GSE74704 | SETD7 | 80854 | 0 | 6 | 14 | |
| TCGA | SETD7 | 80854 | 10 | 32 | 54 |
Total number of gains: 23; Total number of losses: 156; Total Number of normals: 309.
Somatic mutations of SETD7:
Generating mutation plots.
Highly correlated genes for SETD7:
Showing top 20/345 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SETD7 | DOCK10 | 0.801598 | 3 | 0 | 3 |
| SETD7 | RCN1 | 0.7985 | 3 | 0 | 3 |
| SETD7 | NFKB1 | 0.766313 | 3 | 0 | 3 |
| SETD7 | SLC30A5 | 0.763522 | 4 | 0 | 4 |
| SETD7 | LEPROT | 0.750515 | 3 | 0 | 3 |
| SETD7 | TMEM220 | 0.737541 | 3 | 0 | 3 |
| SETD7 | CYP27A1 | 0.727942 | 3 | 0 | 3 |
| SETD7 | CD200 | 0.727215 | 3 | 0 | 3 |
| SETD7 | DCTD | 0.723407 | 4 | 0 | 4 |
| SETD7 | SH3KBP1 | 0.722802 | 3 | 0 | 3 |
| SETD7 | CSF1 | 0.711523 | 3 | 0 | 3 |
| SETD7 | TMEM218 | 0.711237 | 3 | 0 | 3 |
| SETD7 | BRWD1 | 0.708981 | 3 | 0 | 3 |
| SETD7 | SLC39A13 | 0.708621 | 3 | 0 | 3 |
| SETD7 | ZMAT3 | 0.705148 | 3 | 0 | 3 |
| SETD7 | SEC24D | 0.704056 | 3 | 0 | 3 |
| SETD7 | PPID | 0.703897 | 3 | 0 | 3 |
| SETD7 | PEX2 | 0.702906 | 3 | 0 | 3 |
| SETD7 | DOK6 | 0.700383 | 3 | 0 | 3 |
| SETD7 | POLR3F | 0.700077 | 3 | 0 | 3 |
For details and further investigation, click here
