| Full name: syndecan 2 | Alias Symbol: fibroglycan|SYND2|CD362 | ||
| Type: protein-coding gene | Cytoband: 8q22.1 | ||
| Entrez ID: 6383 | HGNC ID: HGNC:10659 | Ensembl Gene: ENSG00000169439 | OMIM ID: 142460 |
| Drug and gene relationship at DGIdb | |||
SDC2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of SDC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SDC2 | 6383 | 212158_at | -0.9744 | 0.3530 | |
| GSE20347 | SDC2 | 6383 | 212157_at | 0.1611 | 0.2396 | |
| GSE23400 | SDC2 | 6383 | 212158_at | 0.2522 | 0.1772 | |
| GSE26886 | SDC2 | 6383 | 212157_at | 0.6696 | 0.0002 | |
| GSE29001 | SDC2 | 6383 | 212158_at | 1.0815 | 0.0394 | |
| GSE38129 | SDC2 | 6383 | 212158_at | 0.4569 | 0.4187 | |
| GSE45670 | SDC2 | 6383 | 212158_at | -1.9317 | 0.0063 | |
| GSE63941 | SDC2 | 6383 | 212154_at | -4.1669 | 0.0296 | |
| GSE77861 | SDC2 | 6383 | 212157_at | 0.2140 | 0.0918 | |
| SRP007169 | SDC2 | 6383 | RNAseq | 3.6322 | 0.0000 | |
| SRP008496 | SDC2 | 6383 | RNAseq | 4.1472 | 0.0000 | |
| SRP064894 | SDC2 | 6383 | RNAseq | 0.3294 | 0.3107 | |
| SRP133303 | SDC2 | 6383 | RNAseq | 0.5967 | 0.0568 | |
| SRP159526 | SDC2 | 6383 | RNAseq | 0.7847 | 0.0925 | |
| SRP193095 | SDC2 | 6383 | RNAseq | 1.5037 | 0.0000 | |
| SRP219564 | SDC2 | 6383 | RNAseq | -0.1840 | 0.7681 | |
| TCGA | SDC2 | 6383 | RNAseq | -0.2619 | 0.0207 |
Upregulated datasets: 4; Downregulated datasets: 2.
Survival by SDC2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SDC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SDC2 | 6383 | 16 | 0 | 14 | |
| GSE20123 | SDC2 | 6383 | 17 | 0 | 13 | |
| GSE43470 | SDC2 | 6383 | 21 | 1 | 21 | |
| GSE46452 | SDC2 | 6383 | 23 | 0 | 36 | |
| GSE47630 | SDC2 | 6383 | 24 | 0 | 16 | |
| GSE54993 | SDC2 | 6383 | 0 | 20 | 50 | |
| GSE54994 | SDC2 | 6383 | 35 | 1 | 17 | |
| GSE60625 | SDC2 | 6383 | 0 | 4 | 7 | |
| GSE74703 | SDC2 | 6383 | 18 | 1 | 17 | |
| GSE74704 | SDC2 | 6383 | 12 | 0 | 8 | |
| TCGA | SDC2 | 6383 | 56 | 2 | 38 |
Total number of gains: 222; Total number of losses: 29; Total Number of normals: 237.
Somatic mutations of SDC2:
Generating mutation plots.
Highly correlated genes for SDC2:
Showing top 20/854 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SDC2 | MYADM | 0.798852 | 3 | 0 | 3 |
| SDC2 | EID2B | 0.760842 | 3 | 0 | 3 |
| SDC2 | PMP22 | 0.755649 | 9 | 0 | 8 |
| SDC2 | FKBP7 | 0.740802 | 4 | 0 | 4 |
| SDC2 | FSTL1 | 0.740218 | 10 | 0 | 10 |
| SDC2 | C11orf96 | 0.739199 | 4 | 0 | 4 |
| SDC2 | FBN1 | 0.737642 | 10 | 0 | 10 |
| SDC2 | CCDC80 | 0.735117 | 3 | 0 | 3 |
| SDC2 | DCHS1 | 0.725465 | 9 | 0 | 8 |
| SDC2 | FERMT2 | 0.722595 | 10 | 0 | 10 |
| SDC2 | HMCN1 | 0.717725 | 5 | 0 | 5 |
| SDC2 | SGCE | 0.717023 | 9 | 0 | 8 |
| SDC2 | TIMP2 | 0.711905 | 4 | 0 | 3 |
| SDC2 | HEPH | 0.707066 | 7 | 0 | 6 |
| SDC2 | ITIH5 | 0.706566 | 3 | 0 | 3 |
| SDC2 | NID1 | 0.704483 | 8 | 0 | 8 |
| SDC2 | TOX2 | 0.701988 | 3 | 0 | 3 |
| SDC2 | DDR2 | 0.701628 | 8 | 0 | 8 |
| SDC2 | DPYSL2 | 0.699683 | 10 | 0 | 8 |
| SDC2 | STARD13 | 0.698516 | 6 | 0 | 5 |
For details and further investigation, click here
