| Full name: TIMP metallopeptidase inhibitor 2 | Alias Symbol: CSC-21K | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 7077 | HGNC ID: HGNC:11821 | Ensembl Gene: ENSG00000035862 | OMIM ID: 188825 |
| Drug and gene relationship at DGIdb | |||
Expression of TIMP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TIMP2 | 7077 | 231579_s_at | -0.6130 | 0.5107 | |
| GSE20347 | TIMP2 | 7077 | 203167_at | -1.3115 | 0.0000 | |
| GSE23400 | TIMP2 | 7077 | 203167_at | -0.6513 | 0.0000 | |
| GSE26886 | TIMP2 | 7077 | 231579_s_at | -0.4862 | 0.1825 | |
| GSE29001 | TIMP2 | 7077 | 203167_at | -1.2751 | 0.0067 | |
| GSE38129 | TIMP2 | 7077 | 203167_at | -1.0360 | 0.0000 | |
| GSE45670 | TIMP2 | 7077 | 231579_s_at | -1.4004 | 0.0011 | |
| GSE53622 | TIMP2 | 7077 | 152822 | 0.0309 | 0.8330 | |
| GSE53624 | TIMP2 | 7077 | 152822 | 0.3751 | 0.0001 | |
| GSE63941 | TIMP2 | 7077 | 231579_s_at | -4.3682 | 0.0013 | |
| GSE77861 | TIMP2 | 7077 | 231579_s_at | 0.2989 | 0.6832 | |
| GSE97050 | TIMP2 | 7077 | A_33_P3382177 | -0.0071 | 0.9916 | |
| SRP007169 | TIMP2 | 7077 | RNAseq | 0.7247 | 0.2325 | |
| SRP008496 | TIMP2 | 7077 | RNAseq | 0.6868 | 0.0665 | |
| SRP064894 | TIMP2 | 7077 | RNAseq | 0.4207 | 0.1461 | |
| SRP133303 | TIMP2 | 7077 | RNAseq | 0.6538 | 0.0415 | |
| SRP159526 | TIMP2 | 7077 | RNAseq | 0.1808 | 0.5410 | |
| SRP193095 | TIMP2 | 7077 | RNAseq | 0.7077 | 0.0196 | |
| SRP219564 | TIMP2 | 7077 | RNAseq | 0.3838 | 0.5213 | |
| TCGA | TIMP2 | 7077 | RNAseq | -0.1343 | 0.1059 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by TIMP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TIMP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TIMP2 | 7077 | 4 | 3 | 23 | |
| GSE20123 | TIMP2 | 7077 | 4 | 3 | 23 | |
| GSE43470 | TIMP2 | 7077 | 3 | 4 | 36 | |
| GSE46452 | TIMP2 | 7077 | 33 | 0 | 26 | |
| GSE47630 | TIMP2 | 7077 | 8 | 1 | 31 | |
| GSE54993 | TIMP2 | 7077 | 2 | 5 | 63 | |
| GSE54994 | TIMP2 | 7077 | 10 | 5 | 38 | |
| GSE60625 | TIMP2 | 7077 | 6 | 0 | 5 | |
| GSE74703 | TIMP2 | 7077 | 3 | 2 | 31 | |
| GSE74704 | TIMP2 | 7077 | 4 | 3 | 13 | |
| TCGA | TIMP2 | 7077 | 30 | 9 | 57 |
Total number of gains: 107; Total number of losses: 35; Total Number of normals: 346.
Somatic mutations of TIMP2:
Generating mutation plots.
Highly correlated genes for TIMP2:
Showing top 20/573 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TIMP2 | C11orf96 | 0.746797 | 3 | 0 | 3 |
| TIMP2 | SYNE1 | 0.73766 | 4 | 0 | 3 |
| TIMP2 | PINK1 | 0.737303 | 5 | 0 | 5 |
| TIMP2 | FILIP1L | 0.734098 | 8 | 0 | 7 |
| TIMP2 | CALD1 | 0.727005 | 8 | 0 | 7 |
| TIMP2 | DCN | 0.725156 | 9 | 0 | 7 |
| TIMP2 | DNM3OS | 0.718871 | 4 | 0 | 3 |
| TIMP2 | SDC2 | 0.711905 | 4 | 0 | 3 |
| TIMP2 | ITGA1 | 0.706223 | 7 | 0 | 7 |
| TIMP2 | RNF10 | 0.703269 | 4 | 0 | 4 |
| TIMP2 | COL8A1 | 0.702119 | 8 | 0 | 7 |
| TIMP2 | CNRIP1 | 0.700324 | 8 | 0 | 6 |
| TIMP2 | ANXA6 | 0.696151 | 7 | 0 | 6 |
| TIMP2 | SYNPO2 | 0.694478 | 3 | 0 | 3 |
| TIMP2 | FIBIN | 0.694289 | 5 | 0 | 4 |
| TIMP2 | NAP1L3 | 0.693729 | 5 | 0 | 4 |
| TIMP2 | ST3GAL4 | 0.692727 | 4 | 0 | 4 |
| TIMP2 | EMILIN1 | 0.691763 | 8 | 0 | 7 |
| TIMP2 | CLMP | 0.690895 | 6 | 0 | 6 |
| TIMP2 | TBX5-AS1 | 0.676512 | 5 | 0 | 4 |
For details and further investigation, click here
