| Full name: SEC11 homolog A, signal peptidase complex subunit | Alias Symbol: SPC18|sid2895|SPCS4A | ||
| Type: protein-coding gene | Cytoband: 15q25.2 | ||
| Entrez ID: 23478 | HGNC ID: HGNC:17718 | Ensembl Gene: ENSG00000140612 | OMIM ID: 618258 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SEC11A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEC11A | 23478 | 201290_at | 0.0332 | 0.9518 | |
| GSE20347 | SEC11A | 23478 | 201290_at | 0.2288 | 0.0385 | |
| GSE23400 | SEC11A | 23478 | 201290_at | 0.4008 | 0.0000 | |
| GSE26886 | SEC11A | 23478 | 201290_at | -0.0136 | 0.9400 | |
| GSE29001 | SEC11A | 23478 | 201290_at | 0.2904 | 0.1258 | |
| GSE38129 | SEC11A | 23478 | 201290_at | 0.3248 | 0.0002 | |
| GSE45670 | SEC11A | 23478 | 201290_at | 0.0587 | 0.6435 | |
| GSE53622 | SEC11A | 23478 | 20520 | 0.3363 | 0.0000 | |
| GSE53624 | SEC11A | 23478 | 20520 | 0.5352 | 0.0000 | |
| GSE63941 | SEC11A | 23478 | 201290_at | -0.2281 | 0.5090 | |
| GSE77861 | SEC11A | 23478 | 201290_at | 0.1844 | 0.3597 | |
| GSE97050 | SEC11A | 23478 | A_23_P380917 | 0.1518 | 0.5212 | |
| SRP007169 | SEC11A | 23478 | RNAseq | -0.1395 | 0.6518 | |
| SRP008496 | SEC11A | 23478 | RNAseq | -0.0527 | 0.7386 | |
| SRP064894 | SEC11A | 23478 | RNAseq | 0.3161 | 0.0738 | |
| SRP133303 | SEC11A | 23478 | RNAseq | 0.3043 | 0.0218 | |
| SRP159526 | SEC11A | 23478 | RNAseq | 0.2048 | 0.3685 | |
| SRP193095 | SEC11A | 23478 | RNAseq | -0.1350 | 0.2850 | |
| SRP219564 | SEC11A | 23478 | RNAseq | 0.2903 | 0.3508 | |
| TCGA | SEC11A | 23478 | RNAseq | 0.0336 | 0.4916 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SEC11A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEC11A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEC11A | 23478 | 8 | 0 | 22 | |
| GSE20123 | SEC11A | 23478 | 8 | 0 | 22 | |
| GSE43470 | SEC11A | 23478 | 4 | 4 | 35 | |
| GSE46452 | SEC11A | 23478 | 3 | 7 | 49 | |
| GSE47630 | SEC11A | 23478 | 8 | 10 | 22 | |
| GSE54993 | SEC11A | 23478 | 5 | 6 | 59 | |
| GSE54994 | SEC11A | 23478 | 6 | 6 | 41 | |
| GSE60625 | SEC11A | 23478 | 4 | 0 | 7 | |
| GSE74703 | SEC11A | 23478 | 4 | 2 | 30 | |
| GSE74704 | SEC11A | 23478 | 4 | 0 | 16 | |
| TCGA | SEC11A | 23478 | 16 | 13 | 67 |
Total number of gains: 70; Total number of losses: 48; Total Number of normals: 370.
Somatic mutations of SEC11A:
Generating mutation plots.
Highly correlated genes for SEC11A:
Showing top 20/954 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEC11A | EPAS1 | 0.779036 | 3 | 0 | 3 |
| SEC11A | DUSP18 | 0.774324 | 3 | 0 | 3 |
| SEC11A | KTI12 | 0.764335 | 3 | 0 | 3 |
| SEC11A | CD109 | 0.761977 | 3 | 0 | 3 |
| SEC11A | MRPL32 | 0.750319 | 4 | 0 | 4 |
| SEC11A | WASF1 | 0.722002 | 3 | 0 | 3 |
| SEC11A | CRIM1 | 0.721159 | 3 | 0 | 3 |
| SEC11A | ANKS6 | 0.718701 | 3 | 0 | 3 |
| SEC11A | TMX3 | 0.717484 | 3 | 0 | 3 |
| SEC11A | KREMEN1 | 0.715772 | 3 | 0 | 3 |
| SEC11A | B3GALT6 | 0.707568 | 3 | 0 | 3 |
| SEC11A | RNF26 | 0.705938 | 3 | 0 | 3 |
| SEC11A | MAP2K1 | 0.70196 | 4 | 0 | 3 |
| SEC11A | SLC35B2 | 0.696706 | 3 | 0 | 3 |
| SEC11A | EBNA1BP2 | 0.69373 | 3 | 0 | 3 |
| SEC11A | ZDHHC9 | 0.693454 | 3 | 0 | 3 |
| SEC11A | HAUS2 | 0.690797 | 3 | 0 | 3 |
| SEC11A | MRPS26 | 0.690051 | 3 | 0 | 3 |
| SEC11A | REEP3 | 0.689126 | 4 | 0 | 3 |
| SEC11A | AQR | 0.688531 | 4 | 0 | 3 |
For details and further investigation, click here
