MAP2K1

 

Full name: mitogen-activated protein kinase kinase 1 Alias Symbol: MEK1|MAPKK1
Type: protein-coding gene Cytoband: 15q22.31
Entrez ID: 5604 HGNC ID: HGNC:6840 Ensembl Gene: ENSG00000169032 OMIM ID: 176872
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

MAP2K1 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04114Oocyte meiosis
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04210Apoptosis
hsa04270Vascular smooth muscle contraction
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04540Gap junction
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04620Toll-like receptor signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04668TNF signaling pathway
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04730Long-term depression
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa05020Prion diseases
hsa05034Alcoholism
hsa05161Hepatitis B
hsa05164Influenza A
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05210Colorectal cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05216Thyroid cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of MAP2K1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MAP2K1 5604 202670_at -0.2488 0.7082
GSE20347 MAP2K1 5604 202670_at -0.5620 0.0023
GSE23400 MAP2K1 5604 202670_at -0.5088 0.0000
GSE26886 MAP2K1 5604 202670_at -1.5306 0.0000
GSE29001 MAP2K1 5604 202670_at -0.5427 0.1298
GSE38129 MAP2K1 5604 202670_at -0.2682 0.1135
GSE45670 MAP2K1 5604 202670_at -0.2476 0.2331
GSE53622 MAP2K1 5604 64654 -0.4468 0.0000
GSE53624 MAP2K1 5604 64654 -0.7662 0.0000
GSE63941 MAP2K1 5604 202670_at -0.0237 0.9641
GSE77861 MAP2K1 5604 202670_at -0.3432 0.1654
GSE97050 MAP2K1 5604 A_23_P20248 -0.2310 0.5851
SRP007169 MAP2K1 5604 RNAseq -2.0573 0.0000
SRP008496 MAP2K1 5604 RNAseq -1.9279 0.0000
SRP064894 MAP2K1 5604 RNAseq -0.6375 0.0014
SRP133303 MAP2K1 5604 RNAseq -0.3122 0.0490
SRP159526 MAP2K1 5604 RNAseq -0.6798 0.1154
SRP193095 MAP2K1 5604 RNAseq -0.6480 0.0007
SRP219564 MAP2K1 5604 RNAseq -0.8267 0.0649
TCGA MAP2K1 5604 RNAseq 0.1095 0.0307

Upregulated datasets: 0; Downregulated datasets: 3.  

 

Survival by MAP2K1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MAP2K1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAP2K1 5604 7 3 20
GSE20123 MAP2K1 5604 7 3 20
GSE43470 MAP2K1 5604 4 6 33
GSE46452 MAP2K1 5604 3 7 49
GSE47630 MAP2K1 5604 8 10 22
GSE54993 MAP2K1 5604 5 6 59
GSE54994 MAP2K1 5604 6 7 40
GSE60625 MAP2K1 5604 4 0 7
GSE74703 MAP2K1 5604 4 3 29
GSE74704 MAP2K1 5604 3 3 14
TCGA MAP2K1 5604 9 16 71

Total number of gains: 60; Total number of losses: 64; Total Number of normals: 364.  

 

Somatic mutations of MAP2K1:

 

Generating mutation plots.

 

Highly correlated genes for MAP2K1:

 

Showing top 20/1371 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAP2K1CCNYL10.818434404
MAP2K1TBC1D200.795835303
MAP2K1PSMA50.776481303
MAP2K1SYTL40.761333303
MAP2K1CARHSP10.750367909
MAP2K1TRERF10.743204403
MAP2K1GRPEL20.742332707
MAP2K1CAPNS20.734957303
MAP2K1S100A160.734436505
MAP2K1PDIK1L0.734165303
MAP2K1ACTR20.733183504
MAP2K1TRIM230.731634303
MAP2K1SPPL2A0.728338403
MAP2K1RWDD2B0.727928303
MAP2K1IFNAR10.724206303
MAP2K1CTTNBP2NL0.721755808
MAP2K1C15orf480.719597606
MAP2K1RAB11A0.71817912012
MAP2K1GANC0.718013707
MAP2K1TMED30.7173810010

For details and further investigation, click here