WASF1

 

Full name: WASP family member 1 Alias Symbol: WAVE1|SCAR1|KIAA0269|WAVE
Type: protein-coding gene Cytoband: 6q21
Entrez ID: 8936 HGNC ID: HGNC:12732 Ensembl Gene: ENSG00000112290 OMIM ID: 605035
Drug and gene relationship at DGIdb

 

WASF1 involved pathways:

KEGG pathway Description View
hsa04520Adherens junction
hsa04666Fc gamma R-mediated phagocytosis
hsa04810Regulation of actin cytoskeleton
hsa05100Bacterial invasion of epithelial cells
hsa05131Shigellosis
hsa05132Salmonella infection
hsa05231Choline metabolism in cancer

 

Expression of WASF1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 WASF1 8936 204165_at 0.1460 0.8664
GSE20347 WASF1 8936 204165_at -0.0405 0.8967
GSE23400 WASF1 8936 204165_at 0.3175 0.0046
GSE26886 WASF1 8936 204165_at 0.1437 0.7363
GSE29001 WASF1 8936 204165_at 0.1272 0.8027
GSE38129 WASF1 8936 204165_at -0.0552 0.8368
GSE45670 WASF1 8936 204165_at 0.0274 0.9516
GSE53622 WASF1 8936 80443 0.0565 0.6742
GSE53624 WASF1 8936 119995 0.1282 0.2056
GSE63941 WASF1 8936 204165_at -0.3931 0.6458
GSE77861 WASF1 8936 204165_at -0.0558 0.9200
GSE97050 WASF1 8936 A_33_P3243812 -0.6368 0.1552
SRP007169 WASF1 8936 RNAseq 1.2244 0.0152
SRP008496 WASF1 8936 RNAseq 1.2736 0.0017
SRP064894 WASF1 8936 RNAseq 0.3145 0.2522
SRP133303 WASF1 8936 RNAseq -0.3190 0.3439
SRP159526 WASF1 8936 RNAseq 0.6247 0.1919
SRP193095 WASF1 8936 RNAseq -0.0722 0.7941
SRP219564 WASF1 8936 RNAseq 0.3258 0.5520
TCGA WASF1 8936 RNAseq 0.5199 0.0001

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by WASF1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of WASF1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 WASF1 8936 2 3 25
GSE20123 WASF1 8936 2 2 26
GSE43470 WASF1 8936 3 1 39
GSE46452 WASF1 8936 2 11 46
GSE47630 WASF1 8936 9 4 27
GSE54993 WASF1 8936 3 2 65
GSE54994 WASF1 8936 8 8 37
GSE60625 WASF1 8936 0 2 9
GSE74703 WASF1 8936 2 1 33
GSE74704 WASF1 8936 0 0 20
TCGA WASF1 8936 6 23 67

Total number of gains: 37; Total number of losses: 57; Total Number of normals: 394.  

 

Somatic mutations of WASF1:

 

Generating mutation plots.

 

Highly correlated genes for WASF1:

 

Showing top 20/39 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
WASF1SEC11A0.722002303
WASF1EPC20.683038303
WASF1ABHD40.677652403
WASF1KCTD10.646652303
WASF1PPME10.642557303
WASF1STRBP0.636879303
WASF1TMEM180.633759403
WASF1PLA2G4A0.63208404
WASF1ARMCX60.629571403
WASF1RBMS20.62593303
WASF1DDX560.624639303
WASF1SLC35A10.617369403
WASF1PSMD140.617288303
WASF1RPS30.599418403
WASF1CEP680.591299504
WASF1MRPS310.591503
WASF1PDHX0.585413403
WASF1FH0.585088403
WASF1UVRAG0.582348504
WASF1CLNS1A0.579019503

For details and further investigation, click here