DUSP18

 

Full name: dual specificity phosphatase 18 Alias Symbol: DUSP20
Type: protein-coding gene Cytoband: 22q12.2
Entrez ID: 150290 HGNC ID: HGNC:18484 Ensembl Gene: ENSG00000167065 OMIM ID: 611446
Drug and gene relationship at DGIdb

 

Expression of DUSP18:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DUSP18 150290 227098_at 0.0748 0.8671
GSE26886 DUSP18 150290 227098_at -0.6069 0.0031
GSE45670 DUSP18 150290 227098_at 0.3483 0.0062
GSE53622 DUSP18 150290 20258 -0.0900 0.4080
GSE53624 DUSP18 150290 20258 -0.0650 0.3397
GSE63941 DUSP18 150290 227098_at 0.4211 0.1628
GSE77861 DUSP18 150290 227098_at 0.1658 0.2560
GSE97050 DUSP18 150290 A_23_P143650 0.3458 0.1496
SRP007169 DUSP18 150290 RNAseq -1.1317 0.0083
SRP008496 DUSP18 150290 RNAseq -0.9244 0.0034
SRP064894 DUSP18 150290 RNAseq 0.0328 0.8388
SRP133303 DUSP18 150290 RNAseq 0.0102 0.9167
SRP159526 DUSP18 150290 RNAseq -0.1970 0.3612
SRP193095 DUSP18 150290 RNAseq 0.0142 0.8944
SRP219564 DUSP18 150290 RNAseq 0.0595 0.9069
TCGA DUSP18 150290 RNAseq 0.0836 0.2096

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by DUSP18 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DUSP18:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DUSP18 150290 4 5 21
GSE20123 DUSP18 150290 4 4 22
GSE43470 DUSP18 150290 4 5 34
GSE46452 DUSP18 150290 31 1 27
GSE47630 DUSP18 150290 8 5 27
GSE54993 DUSP18 150290 3 6 61
GSE54994 DUSP18 150290 11 8 34
GSE60625 DUSP18 150290 5 0 6
GSE74703 DUSP18 150290 4 5 27
GSE74704 DUSP18 150290 1 1 18
TCGA DUSP18 150290 27 15 54

Total number of gains: 102; Total number of losses: 55; Total Number of normals: 331.  

 

Somatic mutations of DUSP18:

 

Generating mutation plots.

 

Highly correlated genes for DUSP18:

 

Showing top 20/262 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DUSP18TMEM600.798736303
DUSP18TTC270.787161303
DUSP18SEC11A0.774324303
DUSP18SUMF20.772272303
DUSP18AHCYL20.767566303
DUSP18PALB20.764666303
DUSP18EIF3I0.758205303
DUSP18RAB7A0.73944303
DUSP18CBL0.73876303
DUSP18TERF20.731708303
DUSP18GTF3C60.729681303
DUSP18ALDH1A30.721568303
DUSP18CASP30.718549303
DUSP18FBXO110.717802303
DUSP18NOL120.715336303
DUSP18PATL10.715268303
DUSP18DFFA0.712421303
DUSP18TMEM170.711886303
DUSP18PMM20.709439303
DUSP18COX160.708915303

For details and further investigation, click here