| Full name: SECIS binding protein 2 | Alias Symbol: SBP2 | ||
| Type: protein-coding gene | Cytoband: 9q22.2 | ||
| Entrez ID: 79048 | HGNC ID: HGNC:30972 | Ensembl Gene: ENSG00000187742 | OMIM ID: 607693 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SECISBP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SECISBP2 | 79048 | 224250_s_at | -0.4112 | 0.4742 | |
| GSE20347 | SECISBP2 | 79048 | 218265_at | -0.2033 | 0.0455 | |
| GSE23400 | SECISBP2 | 79048 | 218265_at | -0.0114 | 0.8670 | |
| GSE26886 | SECISBP2 | 79048 | 224250_s_at | 0.2847 | 0.2787 | |
| GSE29001 | SECISBP2 | 79048 | 218265_at | 0.0068 | 0.9796 | |
| GSE38129 | SECISBP2 | 79048 | 218265_at | -0.1279 | 0.1897 | |
| GSE45670 | SECISBP2 | 79048 | 224250_s_at | 0.1084 | 0.4394 | |
| GSE53622 | SECISBP2 | 79048 | 94063 | -0.0053 | 0.9543 | |
| GSE53624 | SECISBP2 | 79048 | 59971 | -0.2541 | 0.0012 | |
| GSE63941 | SECISBP2 | 79048 | 224250_s_at | 0.5354 | 0.1728 | |
| GSE77861 | SECISBP2 | 79048 | 218265_at | -0.1789 | 0.2116 | |
| GSE97050 | SECISBP2 | 79048 | A_23_P84872 | -0.0389 | 0.8728 | |
| SRP007169 | SECISBP2 | 79048 | RNAseq | 0.0451 | 0.8861 | |
| SRP008496 | SECISBP2 | 79048 | RNAseq | 0.0988 | 0.6034 | |
| SRP064894 | SECISBP2 | 79048 | RNAseq | -0.0042 | 0.9694 | |
| SRP133303 | SECISBP2 | 79048 | RNAseq | -0.2124 | 0.0382 | |
| SRP159526 | SECISBP2 | 79048 | RNAseq | -0.2574 | 0.1196 | |
| SRP193095 | SECISBP2 | 79048 | RNAseq | -0.0663 | 0.5914 | |
| SRP219564 | SECISBP2 | 79048 | RNAseq | 0.0079 | 0.9769 | |
| TCGA | SECISBP2 | 79048 | RNAseq | -0.1972 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SECISBP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SECISBP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SECISBP2 | 79048 | 5 | 10 | 15 | |
| GSE20123 | SECISBP2 | 79048 | 5 | 10 | 15 | |
| GSE43470 | SECISBP2 | 79048 | 6 | 3 | 34 | |
| GSE46452 | SECISBP2 | 79048 | 6 | 14 | 39 | |
| GSE47630 | SECISBP2 | 79048 | 1 | 18 | 21 | |
| GSE54993 | SECISBP2 | 79048 | 4 | 2 | 64 | |
| GSE54994 | SECISBP2 | 79048 | 6 | 11 | 36 | |
| GSE60625 | SECISBP2 | 79048 | 0 | 0 | 11 | |
| GSE74703 | SECISBP2 | 79048 | 5 | 3 | 28 | |
| GSE74704 | SECISBP2 | 79048 | 3 | 7 | 10 | |
| TCGA | SECISBP2 | 79048 | 21 | 24 | 51 |
Total number of gains: 62; Total number of losses: 102; Total Number of normals: 324.
Somatic mutations of SECISBP2:
Generating mutation plots.
Highly correlated genes for SECISBP2:
Showing top 20/109 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SECISBP2 | ZNF292 | 0.824797 | 3 | 0 | 3 |
| SECISBP2 | MTIF3 | 0.692664 | 3 | 0 | 3 |
| SECISBP2 | MAN2B2 | 0.689456 | 3 | 0 | 3 |
| SECISBP2 | RPL14 | 0.682916 | 3 | 0 | 3 |
| SECISBP2 | RAP2A | 0.678021 | 5 | 0 | 4 |
| SECISBP2 | TSPAN31 | 0.673503 | 4 | 0 | 4 |
| SECISBP2 | BRWD3 | 0.667401 | 3 | 0 | 3 |
| SECISBP2 | RPL34 | 0.66532 | 3 | 0 | 3 |
| SECISBP2 | ZNF814 | 0.663707 | 3 | 0 | 3 |
| SECISBP2 | RWDD4 | 0.65924 | 3 | 0 | 3 |
| SECISBP2 | MDM4 | 0.657292 | 3 | 0 | 3 |
| SECISBP2 | CLOCK | 0.655643 | 3 | 0 | 3 |
| SECISBP2 | CDC16 | 0.649113 | 3 | 0 | 3 |
| SECISBP2 | UPF3A | 0.647399 | 4 | 0 | 4 |
| SECISBP2 | KLHDC10 | 0.636803 | 4 | 0 | 4 |
| SECISBP2 | LAMP1 | 0.63426 | 3 | 0 | 3 |
| SECISBP2 | CMC1 | 0.624613 | 4 | 0 | 3 |
| SECISBP2 | CLMN | 0.615412 | 3 | 0 | 3 |
| SECISBP2 | TDRD3 | 0.614148 | 5 | 0 | 4 |
| SECISBP2 | TAF9B | 0.613789 | 4 | 0 | 4 |
For details and further investigation, click here
