| Full name: UPF3A regulator of nonsense mediated mRNA decay | Alias Symbol: RENT3A|UPF3|HUPF3A | ||
| Type: protein-coding gene | Cytoband: 13q34 | ||
| Entrez ID: 65110 | HGNC ID: HGNC:20332 | Ensembl Gene: ENSG00000169062 | OMIM ID: 605530 |
| Drug and gene relationship at DGIdb | |||
Expression of UPF3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UPF3A | 65110 | 214323_s_at | -0.2887 | 0.4534 | |
| GSE20347 | UPF3A | 65110 | 214323_s_at | 0.1237 | 0.7327 | |
| GSE23400 | UPF3A | 65110 | 214323_s_at | 0.0008 | 0.9955 | |
| GSE26886 | UPF3A | 65110 | 214323_s_at | -0.0279 | 0.9456 | |
| GSE29001 | UPF3A | 65110 | 214323_s_at | -0.1364 | 0.6459 | |
| GSE38129 | UPF3A | 65110 | 214323_s_at | -0.0985 | 0.6699 | |
| GSE45670 | UPF3A | 65110 | 214323_s_at | -0.1921 | 0.1254 | |
| GSE53622 | UPF3A | 65110 | 122232 | -0.4867 | 0.0000 | |
| GSE53624 | UPF3A | 65110 | 122232 | -0.3881 | 0.0000 | |
| GSE63941 | UPF3A | 65110 | 214323_s_at | -0.4048 | 0.3949 | |
| GSE77861 | UPF3A | 65110 | 214323_s_at | -0.2799 | 0.3423 | |
| GSE97050 | UPF3A | A_21_P0011576 | -0.5239 | 0.1267 | ||
| SRP007169 | UPF3A | 65110 | RNAseq | 0.6776 | 0.2111 | |
| SRP064894 | UPF3A | 65110 | RNAseq | 0.1539 | 0.2447 | |
| SRP133303 | UPF3A | 65110 | RNAseq | -0.3480 | 0.0007 | |
| SRP159526 | UPF3A | 65110 | RNAseq | -0.4418 | 0.1072 | |
| SRP193095 | UPF3A | 65110 | RNAseq | -0.1412 | 0.2861 | |
| SRP219564 | UPF3A | 65110 | RNAseq | 0.1833 | 0.6082 | |
| TCGA | UPF3A | 65110 | RNAseq | -0.1214 | 0.0478 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UPF3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UPF3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UPF3A | 65110 | 6 | 12 | 12 | |
| GSE20123 | UPF3A | 65110 | 6 | 11 | 13 | |
| GSE43470 | UPF3A | 65110 | 4 | 13 | 26 | |
| GSE46452 | UPF3A | 65110 | 3 | 31 | 25 | |
| GSE47630 | UPF3A | 65110 | 3 | 26 | 11 | |
| GSE54993 | UPF3A | 65110 | 12 | 3 | 55 | |
| GSE54994 | UPF3A | 65110 | 9 | 10 | 34 | |
| GSE60625 | UPF3A | 65110 | 0 | 3 | 8 | |
| GSE74703 | UPF3A | 65110 | 3 | 10 | 23 | |
| GSE74704 | UPF3A | 65110 | 4 | 9 | 7 | |
| TCGA | UPF3A | 65110 | 19 | 32 | 45 |
Total number of gains: 69; Total number of losses: 160; Total Number of normals: 259.
Somatic mutations of UPF3A:
Generating mutation plots.
Highly correlated genes for UPF3A:
Showing top 20/243 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UPF3A | BRD8 | 0.756153 | 3 | 0 | 3 |
| UPF3A | ZNF585B | 0.752984 | 3 | 0 | 3 |
| UPF3A | CDC16 | 0.746956 | 13 | 0 | 12 |
| UPF3A | ZNF274 | 0.71196 | 4 | 0 | 4 |
| UPF3A | USP9Y | 0.701345 | 3 | 0 | 3 |
| UPF3A | FAM193B | 0.690445 | 4 | 0 | 3 |
| UPF3A | ARHGEF7 | 0.686509 | 13 | 0 | 11 |
| UPF3A | DDX42 | 0.68636 | 5 | 0 | 5 |
| UPF3A | R3HDM2 | 0.684683 | 4 | 0 | 3 |
| UPF3A | NDUFS1 | 0.680094 | 3 | 0 | 3 |
| UPF3A | EBPL | 0.679608 | 3 | 0 | 3 |
| UPF3A | ESYT2 | 0.675982 | 3 | 0 | 3 |
| UPF3A | N4BP2L2 | 0.675894 | 9 | 0 | 7 |
| UPF3A | ZNF211 | 0.672691 | 3 | 0 | 3 |
| UPF3A | RSBN1 | 0.670659 | 4 | 0 | 3 |
| UPF3A | TRIM56 | 0.669929 | 3 | 0 | 3 |
| UPF3A | ZNF566 | 0.668844 | 4 | 0 | 3 |
| UPF3A | PHF11 | 0.667522 | 6 | 0 | 5 |
| UPF3A | TUBGCP3 | 0.667254 | 10 | 0 | 8 |
| UPF3A | AARS2 | 0.667243 | 3 | 0 | 3 |
For details and further investigation, click here
