| Full name: RAP2A, member of RAS oncogene family | Alias Symbol: K-REV | ||
| Type: protein-coding gene | Cytoband: 13q32.1 | ||
| Entrez ID: 5911 | HGNC ID: HGNC:9861 | Ensembl Gene: ENSG00000125249 | OMIM ID: 179540 |
| Drug and gene relationship at DGIdb | |||
Expression of RAP2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAP2A | 5911 | 221830_at | -0.4958 | 0.2394 | |
| GSE20347 | RAP2A | 5911 | 221830_at | -0.6306 | 0.0001 | |
| GSE23400 | RAP2A | 5911 | 221830_at | -0.5953 | 0.0000 | |
| GSE26886 | RAP2A | 5911 | 221830_at | -1.2275 | 0.0000 | |
| GSE29001 | RAP2A | 5911 | 221830_at | -1.0818 | 0.0282 | |
| GSE38129 | RAP2A | 5911 | 221830_at | -0.4847 | 0.3808 | |
| GSE45670 | RAP2A | 5911 | 225585_at | -0.2943 | 0.0154 | |
| GSE53622 | RAP2A | 5911 | 1217 | -0.5792 | 0.0000 | |
| GSE53624 | RAP2A | 5911 | 1217 | -0.7925 | 0.0000 | |
| GSE63941 | RAP2A | 5911 | 221830_at | 0.3666 | 0.5265 | |
| GSE77861 | RAP2A | 5911 | 221830_at | -0.3008 | 0.3095 | |
| GSE97050 | RAP2A | 5911 | A_24_P81965 | 0.0100 | 0.9774 | |
| SRP007169 | RAP2A | 5911 | RNAseq | -1.9253 | 0.0000 | |
| SRP008496 | RAP2A | 5911 | RNAseq | -1.6669 | 0.0000 | |
| SRP064894 | RAP2A | 5911 | RNAseq | -0.6184 | 0.0058 | |
| SRP133303 | RAP2A | 5911 | RNAseq | -0.2939 | 0.0290 | |
| SRP159526 | RAP2A | 5911 | RNAseq | -0.5533 | 0.0054 | |
| SRP193095 | RAP2A | 5911 | RNAseq | -0.9595 | 0.0000 | |
| SRP219564 | RAP2A | 5911 | RNAseq | -0.6690 | 0.0662 | |
| TCGA | RAP2A | 5911 | RNAseq | 0.1286 | 0.0224 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by RAP2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAP2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAP2A | 5911 | 4 | 9 | 17 | |
| GSE20123 | RAP2A | 5911 | 4 | 8 | 18 | |
| GSE43470 | RAP2A | 5911 | 4 | 12 | 27 | |
| GSE46452 | RAP2A | 5911 | 0 | 32 | 27 | |
| GSE47630 | RAP2A | 5911 | 3 | 26 | 11 | |
| GSE54993 | RAP2A | 5911 | 11 | 3 | 56 | |
| GSE54994 | RAP2A | 5911 | 3 | 12 | 38 | |
| GSE60625 | RAP2A | 5911 | 0 | 3 | 8 | |
| GSE74703 | RAP2A | 5911 | 3 | 10 | 23 | |
| GSE74704 | RAP2A | 5911 | 2 | 8 | 10 | |
| TCGA | RAP2A | 5911 | 13 | 34 | 49 |
Total number of gains: 47; Total number of losses: 157; Total Number of normals: 284.
Somatic mutations of RAP2A:
Generating mutation plots.
Highly correlated genes for RAP2A:
Showing top 20/822 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAP2A | TPD52L2 | 0.748863 | 3 | 0 | 3 |
| RAP2A | WWP1 | 0.743973 | 4 | 0 | 3 |
| RAP2A | SLC6A9 | 0.740623 | 3 | 0 | 3 |
| RAP2A | ZNF292 | 0.736103 | 5 | 0 | 4 |
| RAP2A | APBA1 | 0.725594 | 3 | 0 | 3 |
| RAP2A | RBM20 | 0.711827 | 4 | 0 | 4 |
| RAP2A | TRIP11 | 0.702445 | 3 | 0 | 3 |
| RAP2A | HEATR5A | 0.697921 | 3 | 0 | 3 |
| RAP2A | ZNF12 | 0.695993 | 3 | 0 | 3 |
| RAP2A | RABEP2 | 0.690696 | 3 | 0 | 3 |
| RAP2A | CYP2C19 | 0.689989 | 4 | 0 | 4 |
| RAP2A | ARF5 | 0.685867 | 4 | 0 | 3 |
| RAP2A | TBRG1 | 0.684312 | 3 | 0 | 3 |
| RAP2A | PPIP5K2 | 0.682245 | 4 | 0 | 3 |
| RAP2A | GLRX2 | 0.680869 | 3 | 0 | 3 |
| RAP2A | SECISBP2 | 0.678021 | 5 | 0 | 4 |
| RAP2A | COPE | 0.672886 | 3 | 0 | 3 |
| RAP2A | EXD2 | 0.665635 | 5 | 0 | 4 |
| RAP2A | GOLGA4 | 0.664383 | 6 | 0 | 5 |
| RAP2A | LYSMD3 | 0.661928 | 4 | 0 | 3 |
For details and further investigation, click here
