Full name: clock circadian regulator	Alias Symbol: KIAA0334|KAT13D|bHLHe8
Type: protein-coding gene	Cytoband: 4q12
Entrez ID: 9575	HGNC ID: HGNC:2082	Ensembl Gene: ENSG00000134852	OMIM ID: 601851
Drug and gene relationship at DGIdb

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CLOCK involved pathways:

KEGG pathway	Description	View
hsa04710	Circadian rhythm	View
hsa04728	Dopaminergic synapse	View

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Expression of CLOCK:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	CLOCK	9575	227531_at	-0.5077	0.1166	Show
GSE20347	CLOCK	9575	204980_at	-1.3180	0.0000	Show
GSE23400	CLOCK	9575	204980_at	-0.5355	0.0000	Show
GSE26886	CLOCK	9575	227531_at	-0.9728	0.0002	Show
GSE29001	CLOCK	9575	204980_at	-1.0905	0.0001	Show
GSE38129	CLOCK	9575	204980_at	-0.9822	0.0000	Show
GSE45670	CLOCK	9575	227531_at	-0.5494	0.0298	Show
GSE53622	CLOCK	9575	18016	-0.8770	0.0000	Show
GSE53624	CLOCK	9575	18016	-1.1495	0.0000	Show
GSE63941	CLOCK	9575	227531_at	-1.1745	0.0968	Show
GSE77861	CLOCK	9575	204980_at	-0.8376	0.0191	Show
GSE97050	CLOCK	9575	A_23_P419038	-0.4371	0.1235	Show
SRP007169	CLOCK	9575	RNAseq	-0.6139	0.1966	Show
SRP008496	CLOCK	9575	RNAseq	-0.4207	0.1314	Show
SRP064894	CLOCK	9575	RNAseq	-0.6986	0.0005	Show
SRP133303	CLOCK	9575	RNAseq	-0.5179	0.0005	Show
SRP159526	CLOCK	9575	RNAseq	-1.4387	0.0000	Show
SRP193095	CLOCK	9575	RNAseq	-0.8327	0.0000	Show
SRP219564	CLOCK	9575	RNAseq	-0.9643	0.0012	Show
TCGA	CLOCK	9575	RNAseq	-0.2586	0.0002	Show

Upregulated datasets: 0; Downregulated datasets: 4.  Download Data

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Survival by CLOCK expression:

 

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Copy number change of CLOCK:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	CLOCK	9575	3	11	16	Show
GSE20123	CLOCK	9575	2	11	17	Show
GSE43470	CLOCK	9575	0	14	29	Show
GSE46452	CLOCK	9575	1	36	22	Show
GSE47630	CLOCK	9575	1	18	21	Show
GSE54993	CLOCK	9575	7	0	63	Show
GSE54994	CLOCK	9575	2	10	41	Show
GSE60625	CLOCK	9575	0	0	11	Show
GSE74703	CLOCK	9575	0	12	24	Show
GSE74704	CLOCK	9575	1	6	13	Show
TCGA	CLOCK	9575	20	27	49	Show

Total number of gains: 37; Total number of losses: 145; Total Number of normals: 306.  Download Data

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Somatic mutations of CLOCK:

 

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Highly correlated genes for CLOCK:

 

Showing top 20/1506 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
CLOCK	C5orf51	0.771841	3	0	3
CLOCK	GDPD1	0.76017	3	0	3
CLOCK	FAM98C	0.748477	4	0	4
CLOCK	MGST2	0.747449	11	0	11
CLOCK	GPD1L	0.744404	11	0	11
CLOCK	NFIA	0.739854	7	0	7
CLOCK	CA13	0.739413	3	0	3
CLOCK	ARHGEF10L	0.73912	11	0	10
CLOCK	C12orf29	0.738797	10	0	9
CLOCK	SHROOM3	0.734975	7	0	6
CLOCK	SORT1	0.734458	11	0	10
CLOCK	PAQR8	0.733994	7	0	7
CLOCK	USP54	0.733675	7	0	6
CLOCK	EXPH5	0.727497	10	0	10
CLOCK	LNX1	0.727483	7	0	7
CLOCK	ECHDC2	0.726759	11	0	11
CLOCK	CGNL1	0.726678	7	0	6
CLOCK	KIAA0232	0.723698	11	0	10
CLOCK	UBL3	0.72288	10	0	10
CLOCK	CASC3	0.721382	3	0	3

For details and further investigation, click here