| Full name: semaphorin 3F | Alias Symbol: SEMAK|Sema4 | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 6405 | HGNC ID: HGNC:10728 | Ensembl Gene: ENSG00000001617 | OMIM ID: 601124 |
| Drug and gene relationship at DGIdb | |||
SEMA3F involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of SEMA3F:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEMA3F | 6405 | 35666_at | 0.0167 | 0.9851 | |
| GSE20347 | SEMA3F | 6405 | 35666_at | -0.5575 | 0.0072 | |
| GSE23400 | SEMA3F | 6405 | 35666_at | -0.3716 | 0.0000 | |
| GSE26886 | SEMA3F | 6405 | 35666_at | -0.4459 | 0.0237 | |
| GSE29001 | SEMA3F | 6405 | 35666_at | -0.5979 | 0.1183 | |
| GSE38129 | SEMA3F | 6405 | 35666_at | -0.2410 | 0.3379 | |
| GSE45670 | SEMA3F | 6405 | 35666_at | -0.0257 | 0.9221 | |
| GSE53622 | SEMA3F | 6405 | 141102 | -0.8004 | 0.0000 | |
| GSE53624 | SEMA3F | 6405 | 141102 | -0.9582 | 0.0000 | |
| GSE63941 | SEMA3F | 6405 | 35666_at | 1.7975 | 0.0031 | |
| GSE77861 | SEMA3F | 6405 | 35666_at | -0.2577 | 0.3025 | |
| GSE97050 | SEMA3F | 6405 | A_33_P3813128 | -0.0785 | 0.8883 | |
| SRP007169 | SEMA3F | 6405 | RNAseq | -1.8997 | 0.0000 | |
| SRP008496 | SEMA3F | 6405 | RNAseq | -1.7792 | 0.0000 | |
| SRP064894 | SEMA3F | 6405 | RNAseq | -0.9956 | 0.0000 | |
| SRP133303 | SEMA3F | 6405 | RNAseq | -0.9837 | 0.0000 | |
| SRP159526 | SEMA3F | 6405 | RNAseq | -0.9958 | 0.0020 | |
| SRP193095 | SEMA3F | 6405 | RNAseq | -1.0307 | 0.0000 | |
| SRP219564 | SEMA3F | 6405 | RNAseq | -1.3523 | 0.0373 | |
| TCGA | SEMA3F | 6405 | RNAseq | 0.1527 | 0.0372 |
Upregulated datasets: 1; Downregulated datasets: 4.
Survival by SEMA3F expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEMA3F:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEMA3F | 6405 | 0 | 18 | 12 | |
| GSE20123 | SEMA3F | 6405 | 0 | 19 | 11 | |
| GSE43470 | SEMA3F | 6405 | 0 | 19 | 24 | |
| GSE46452 | SEMA3F | 6405 | 2 | 16 | 41 | |
| GSE47630 | SEMA3F | 6405 | 1 | 24 | 15 | |
| GSE54993 | SEMA3F | 6405 | 6 | 2 | 62 | |
| GSE54994 | SEMA3F | 6405 | 0 | 34 | 19 | |
| GSE60625 | SEMA3F | 6405 | 5 | 0 | 6 | |
| GSE74703 | SEMA3F | 6405 | 0 | 15 | 21 | |
| GSE74704 | SEMA3F | 6405 | 0 | 12 | 8 | |
| TCGA | SEMA3F | 6405 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 237; Total Number of normals: 237.
Somatic mutations of SEMA3F:
Generating mutation plots.
Highly correlated genes for SEMA3F:
Showing top 20/823 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEMA3F | MFSD2B | 0.802882 | 3 | 0 | 3 |
| SEMA3F | NCCRP1 | 0.797213 | 3 | 0 | 3 |
| SEMA3F | FAM163B | 0.785733 | 3 | 0 | 3 |
| SEMA3F | MUC22 | 0.763985 | 3 | 0 | 3 |
| SEMA3F | NOTO | 0.762401 | 3 | 0 | 3 |
| SEMA3F | OTOP3 | 0.760987 | 3 | 0 | 3 |
| SEMA3F | TEN1 | 0.757371 | 3 | 0 | 3 |
| SEMA3F | RNF222 | 0.755361 | 3 | 0 | 3 |
| SEMA3F | NUDT8 | 0.746305 | 3 | 0 | 3 |
| SEMA3F | LIME1 | 0.745466 | 3 | 0 | 3 |
| SEMA3F | TMPRSS11A | 0.744516 | 3 | 0 | 3 |
| SEMA3F | KRTAP20-1 | 0.738924 | 3 | 0 | 3 |
| SEMA3F | SDCBP2 | 0.732514 | 3 | 0 | 3 |
| SEMA3F | KPRP | 0.730587 | 3 | 0 | 3 |
| SEMA3F | EPHA1 | 0.727606 | 9 | 0 | 8 |
| SEMA3F | CSTL1 | 0.720367 | 4 | 0 | 4 |
| SEMA3F | KLHL35 | 0.713432 | 3 | 0 | 3 |
| SEMA3F | CDC20B | 0.712918 | 3 | 0 | 3 |
| SEMA3F | OR10G8 | 0.711793 | 3 | 0 | 3 |
| SEMA3F | CLEC18C | 0.711389 | 3 | 0 | 3 |
For details and further investigation, click here
