SEPHS1

 

Full name: selenophosphate synthetase 1 Alias Symbol: SPS|SPS1
Type: protein-coding gene Cytoband: 10p13
Entrez ID: 22929 HGNC ID: HGNC:19685 Ensembl Gene: ENSG00000086475 OMIM ID: 600902
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of SEPHS1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SEPHS1 22929 208939_at 0.4095 0.2516
GSE20347 SEPHS1 22929 208939_at 0.6256 0.0017
GSE23400 SEPHS1 22929 208939_at 0.5311 0.0000
GSE26886 SEPHS1 22929 208939_at 0.3769 0.1063
GSE29001 SEPHS1 22929 208940_at 0.3390 0.4962
GSE38129 SEPHS1 22929 208939_at 0.5608 0.0005
GSE45670 SEPHS1 22929 208939_at -0.0126 0.9638
GSE53622 SEPHS1 22929 64550 0.5565 0.0000
GSE53624 SEPHS1 22929 64550 0.4539 0.0000
GSE63941 SEPHS1 22929 208939_at 0.4505 0.2875
GSE77861 SEPHS1 22929 208939_at 0.0048 0.9908
GSE97050 SEPHS1 22929 A_23_P150092 0.0160 0.9541
SRP007169 SEPHS1 22929 RNAseq 0.0924 0.7907
SRP008496 SEPHS1 22929 RNAseq 0.3532 0.1200
SRP064894 SEPHS1 22929 RNAseq 0.4277 0.0267
SRP133303 SEPHS1 22929 RNAseq 0.1490 0.2970
SRP159526 SEPHS1 22929 RNAseq 0.3739 0.0880
SRP193095 SEPHS1 22929 RNAseq 0.0282 0.7752
SRP219564 SEPHS1 22929 RNAseq 0.0449 0.8834
TCGA SEPHS1 22929 RNAseq 0.0695 0.1915

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by SEPHS1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SEPHS1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SEPHS1 22929 4 8 18
GSE20123 SEPHS1 22929 4 7 19
GSE43470 SEPHS1 22929 3 5 35
GSE46452 SEPHS1 22929 2 14 43
GSE47630 SEPHS1 22929 6 14 20
GSE54993 SEPHS1 22929 11 1 58
GSE54994 SEPHS1 22929 4 9 40
GSE60625 SEPHS1 22929 0 0 11
GSE74703 SEPHS1 22929 2 3 31
GSE74704 SEPHS1 22929 0 6 14
TCGA SEPHS1 22929 21 24 51

Total number of gains: 57; Total number of losses: 91; Total Number of normals: 340.  

 

Somatic mutations of SEPHS1:

 

Generating mutation plots.

 

Highly correlated genes for SEPHS1:

 

Showing top 20/880 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SEPHS1LDLRAP10.748695303
SEPHS1NCOA50.746896303
SEPHS1ZXDA0.736484303
SEPHS1SNRPD30.735704303
SEPHS1PIF10.73211404
SEPHS1FBXW80.72229303
SEPHS1PRPF4B0.718327303
SEPHS1RABL2A0.712388303
SEPHS1SLC25A10.71024303
SEPHS1LRRC340.708007303
SEPHS1ATP1A10.7065303
SEPHS1IFIT50.695957303
SEPHS1NEDD10.69509303
SEPHS1ZNF6440.687213403
SEPHS1NAF10.684934303
SEPHS1FAM120A0.6841403
SEPHS1PXYLP10.683702403
SEPHS1MRPL40.682946403
SEPHS1ABL10.680716303
SEPHS1FTO0.678319303

For details and further investigation, click here