Full name: ATPase Na+/K+ transporting subunit alpha 1	Alias Symbol:
Type: protein-coding gene	Cytoband: 1p13.1
Entrez ID: 476	HGNC ID: HGNC:799	Ensembl Gene: ENSG00000163399	OMIM ID: 182310
Related drugs: ACETYLDIGITOXIN, ALMITRINE, BEPRIDIL, CHEMBL38827, CHEMBL444449, CICLOPIROX, DESLANOSIDE, DIGITOXIN, DIGOXIN, ISTAROXIME... [more]
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 192/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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ATP1A1 involved pathways:

KEGG pathway	Description	View
hsa04022	cGMP-PKG signaling pathway	View
hsa04024	cAMP signaling pathway	View
hsa04261	Adrenergic signaling in cardiomyocytes	View
hsa04919	Thyroid hormone signaling pathway	View
hsa04960	Aldosterone-regulated sodium reabsorption	View
hsa04961	Endocrine and other factor-regulated calcium reabsorption	View

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Expression of ATP1A1:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	ATP1A1	476	220948_s_at	0.2646	0.5751	Show
GSE20347	ATP1A1	476	220948_s_at	0.2149	0.3249	Show
GSE23400	ATP1A1	476	220948_s_at	0.5895	0.0000	Show
GSE26886	ATP1A1	476	220948_s_at	-0.1327	0.6736	Show
GSE29001	ATP1A1	476	220948_s_at	0.4124	0.3453	Show
GSE38129	ATP1A1	476	220948_s_at	0.5284	0.0010	Show
GSE45670	ATP1A1	476	220948_s_at	0.5753	0.0024	Show
GSE53622	ATP1A1	476	85590	0.6845	0.0000	Show
GSE53624	ATP1A1	476	85590	0.8128	0.0000	Show
GSE63941	ATP1A1	476	220948_s_at	0.2743	0.5765	Show
GSE77861	ATP1A1	476	220948_s_at	0.1663	0.7150	Show
GSE97050	ATP1A1	476	A_23_P1072	0.5972	0.1496	Show
SRP007169	ATP1A1	476	RNAseq	0.3842	0.3078	Show
SRP008496	ATP1A1	476	RNAseq	0.2548	0.2915	Show
SRP064894	ATP1A1	476	RNAseq	0.2586	0.1831	Show
SRP133303	ATP1A1	476	RNAseq	0.4939	0.0194	Show
SRP159526	ATP1A1	476	RNAseq	0.0734	0.7758	Show
SRP193095	ATP1A1	476	RNAseq	0.0958	0.5808	Show
SRP219564	ATP1A1	476	RNAseq	0.5938	0.2457	Show
TCGA	ATP1A1	476	RNAseq	0.0439	0.3612	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

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Survival by ATP1A1 expression:

 

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Copy number change of ATP1A1:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	ATP1A1	476	0	9	21	Show
GSE20123	ATP1A1	476	0	9	21	Show
GSE43470	ATP1A1	476	0	6	37	Show
GSE46452	ATP1A1	476	2	1	56	Show
GSE47630	ATP1A1	476	9	5	26	Show
GSE54993	ATP1A1	476	0	1	69	Show
GSE54994	ATP1A1	476	7	3	43	Show
GSE60625	ATP1A1	476	0	0	11	Show
GSE74703	ATP1A1	476	0	5	31	Show
GSE74704	ATP1A1	476	0	5	15	Show
TCGA	ATP1A1	476	15	28	53	Show

Total number of gains: 33; Total number of losses: 72; Total Number of normals: 383.  Download Data

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Somatic mutations of ATP1A1:

 

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Highly correlated genes for ATP1A1:

 

Showing top 20/815 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
ATP1A1	CDC27	0.748185	3	0	3
ATP1A1	PRELID1	0.742609	3	0	3
ATP1A1	FAM89A	0.719012	3	0	3
ATP1A1	EBNA1BP2	0.712813	3	0	3
ATP1A1	SEPHS1	0.7065	3	0	3
ATP1A1	RPS4X	0.706399	3	0	3
ATP1A1	UCK2	0.69893	3	0	3
ATP1A1	AFAP1L2	0.6932	3	0	3
ATP1A1	HIBADH	0.691772	3	0	3
ATP1A1	HM13	0.688666	3	0	3
ATP1A1	FYTTD1	0.681477	3	0	3
ATP1A1	NIT1	0.67851	3	0	3
ATP1A1	NOP56	0.678019	3	0	3
ATP1A1	PYCR2	0.673842	3	0	3
ATP1A1	ADCY3	0.673247	3	0	3
ATP1A1	NLN	0.671659	3	0	3
ATP1A1	MET	0.670125	6	0	5
ATP1A1	RMI2	0.668202	4	0	4
ATP1A1	DCAF13	0.667843	5	0	5
ATP1A1	PPAT	0.66599	3	0	3

For details and further investigation, click here