| Full name: mitochondrial ribosomal protein L4 | Alias Symbol: CGI-28 | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 51073 | HGNC ID: HGNC:14276 | Ensembl Gene: ENSG00000105364 | OMIM ID: 611823 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MRPL4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL4 | 51073 | 218105_s_at | 0.5036 | 0.4616 | |
| GSE20347 | MRPL4 | 51073 | 218105_s_at | 0.4211 | 0.0084 | |
| GSE23400 | MRPL4 | 51073 | 218105_s_at | 0.3749 | 0.0000 | |
| GSE26886 | MRPL4 | 51073 | 218105_s_at | 0.7559 | 0.0000 | |
| GSE29001 | MRPL4 | 51073 | 218105_s_at | 0.4761 | 0.1323 | |
| GSE38129 | MRPL4 | 51073 | 218105_s_at | 0.4413 | 0.0016 | |
| GSE45670 | MRPL4 | 51073 | 218105_s_at | 0.5465 | 0.0031 | |
| GSE63941 | MRPL4 | 51073 | 218105_s_at | 1.7297 | 0.0020 | |
| GSE77861 | MRPL4 | 51073 | 218105_s_at | 0.8580 | 0.0026 | |
| GSE97050 | MRPL4 | 51073 | A_33_P3390477 | 0.1954 | 0.3710 | |
| SRP007169 | MRPL4 | 51073 | RNAseq | -0.0741 | 0.8390 | |
| SRP008496 | MRPL4 | 51073 | RNAseq | 0.0322 | 0.9036 | |
| SRP064894 | MRPL4 | 51073 | RNAseq | 0.7934 | 0.0137 | |
| SRP133303 | MRPL4 | 51073 | RNAseq | 0.4406 | 0.0323 | |
| SRP159526 | MRPL4 | 51073 | RNAseq | 0.5225 | 0.0129 | |
| SRP193095 | MRPL4 | 51073 | RNAseq | 0.2681 | 0.0282 | |
| TCGA | MRPL4 | 51073 | RNAseq | 0.2338 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MRPL4 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of MRPL4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL4 | 51073 | 4 | 3 | 23 | |
| GSE20123 | MRPL4 | 51073 | 3 | 1 | 26 | |
| GSE43470 | MRPL4 | 51073 | 3 | 6 | 34 | |
| GSE46452 | MRPL4 | 51073 | 47 | 1 | 11 | |
| GSE47630 | MRPL4 | 51073 | 4 | 7 | 29 | |
| GSE54993 | MRPL4 | 51073 | 16 | 3 | 51 | |
| GSE54994 | MRPL4 | 51073 | 7 | 13 | 33 | |
| GSE60625 | MRPL4 | 51073 | 9 | 0 | 2 | |
| GSE74703 | MRPL4 | 51073 | 3 | 4 | 29 | |
| GSE74704 | MRPL4 | 51073 | 0 | 1 | 19 | |
| TCGA | MRPL4 | 51073 | 13 | 15 | 68 |
Total number of gains: 109; Total number of losses: 54; Total Number of normals: 325.
Somatic mutations of MRPL4:
Generating mutation plots.
Highly correlated genes for MRPL4:
Showing top 20/1476 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL4 | RNFT2 | 0.758531 | 3 | 0 | 3 |
| MRPL4 | NAA60 | 0.748716 | 3 | 0 | 3 |
| MRPL4 | BOLA3 | 0.739432 | 4 | 0 | 4 |
| MRPL4 | SLC44A1 | 0.738231 | 4 | 0 | 4 |
| MRPL4 | ZNF317 | 0.737854 | 5 | 0 | 5 |
| MRPL4 | FMNL2 | 0.73682 | 3 | 0 | 3 |
| MRPL4 | RAVER1 | 0.730889 | 7 | 0 | 6 |
| MRPL4 | NR2C2AP | 0.722631 | 6 | 0 | 6 |
| MRPL4 | EXOC6 | 0.716385 | 4 | 0 | 3 |
| MRPL4 | RAD23A | 0.710853 | 11 | 0 | 11 |
| MRPL4 | COLGALT1 | 0.710112 | 8 | 0 | 8 |
| MRPL4 | LSM8 | 0.709175 | 6 | 0 | 6 |
| MRPL4 | DCTPP1 | 0.707702 | 9 | 0 | 9 |
| MRPL4 | STPG1 | 0.706168 | 3 | 0 | 3 |
| MRPL4 | FUCA2 | 0.705752 | 3 | 0 | 3 |
| MRPL4 | TARBP2 | 0.702069 | 5 | 0 | 5 |
| MRPL4 | C6orf52 | 0.701663 | 3 | 0 | 3 |
| MRPL4 | EFTUD2 | 0.701623 | 6 | 0 | 6 |
| MRPL4 | HAS3 | 0.696605 | 4 | 0 | 4 |
| MRPL4 | ILF3 | 0.695658 | 9 | 0 | 9 |
For details and further investigation, click here
