| Full name: serpin family B member 6 | Alias Symbol: PTI|CAP | ||
| Type: protein-coding gene | Cytoband: 6p25.2 | ||
| Entrez ID: 5269 | HGNC ID: HGNC:8950 | Ensembl Gene: ENSG00000124570 | OMIM ID: 173321 |
| Drug and gene relationship at DGIdb | |||
Expression of SERPINB6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERPINB6 | 5269 | 211474_s_at | -0.8563 | 0.1217 | |
| GSE20347 | SERPINB6 | 5269 | 211474_s_at | -1.7159 | 0.0000 | |
| GSE23400 | SERPINB6 | 5269 | 211474_s_at | -1.0705 | 0.0000 | |
| GSE26886 | SERPINB6 | 5269 | 211474_s_at | -2.3908 | 0.0000 | |
| GSE29001 | SERPINB6 | 5269 | 211474_s_at | -2.1522 | 0.0001 | |
| GSE38129 | SERPINB6 | 5269 | 211474_s_at | -1.4245 | 0.0000 | |
| GSE45670 | SERPINB6 | 5269 | 211474_s_at | -0.7141 | 0.0074 | |
| GSE53622 | SERPINB6 | 5269 | 57972 | -1.8450 | 0.0000 | |
| GSE53624 | SERPINB6 | 5269 | 57972 | -1.7774 | 0.0000 | |
| GSE63941 | SERPINB6 | 5269 | 211474_s_at | -0.8969 | 0.4657 | |
| GSE77861 | SERPINB6 | 5269 | 211474_s_at | -0.9364 | 0.0018 | |
| GSE97050 | SERPINB6 | 5269 | A_33_P3303136 | -1.5070 | 0.0834 | |
| SRP007169 | SERPINB6 | 5269 | RNAseq | -3.4847 | 0.0000 | |
| SRP008496 | SERPINB6 | 5269 | RNAseq | -3.0119 | 0.0000 | |
| SRP064894 | SERPINB6 | 5269 | RNAseq | -0.6492 | 0.0510 | |
| SRP133303 | SERPINB6 | 5269 | RNAseq | -1.2288 | 0.0000 | |
| SRP159526 | SERPINB6 | 5269 | RNAseq | -1.5857 | 0.0000 | |
| SRP193095 | SERPINB6 | 5269 | RNAseq | -1.4234 | 0.0000 | |
| SRP219564 | SERPINB6 | 5269 | RNAseq | -0.7363 | 0.0278 | |
| TCGA | SERPINB6 | 5269 | RNAseq | -0.2668 | 0.0019 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by SERPINB6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERPINB6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERPINB6 | 5269 | 4 | 5 | 21 | |
| GSE20123 | SERPINB6 | 5269 | 4 | 5 | 21 | |
| GSE43470 | SERPINB6 | 5269 | 8 | 4 | 31 | |
| GSE46452 | SERPINB6 | 5269 | 1 | 10 | 48 | |
| GSE47630 | SERPINB6 | 5269 | 7 | 8 | 25 | |
| GSE54993 | SERPINB6 | 5269 | 1 | 1 | 68 | |
| GSE54994 | SERPINB6 | 5269 | 10 | 3 | 40 | |
| GSE60625 | SERPINB6 | 5269 | 0 | 1 | 10 | |
| GSE74703 | SERPINB6 | 5269 | 7 | 3 | 26 | |
| GSE74704 | SERPINB6 | 5269 | 2 | 2 | 16 | |
| TCGA | SERPINB6 | 5269 | 17 | 30 | 49 |
Total number of gains: 61; Total number of losses: 72; Total Number of normals: 355.
Somatic mutations of SERPINB6:
Generating mutation plots.
Highly correlated genes for SERPINB6:
Showing top 20/1696 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERPINB6 | FCHO2 | 0.817474 | 7 | 0 | 7 |
| SERPINB6 | SNORA68 | 0.816644 | 4 | 0 | 4 |
| SERPINB6 | FAM214A | 0.815072 | 6 | 0 | 6 |
| SERPINB6 | PHACTR4 | 0.812636 | 11 | 0 | 11 |
| SERPINB6 | SHROOM3 | 0.80331 | 7 | 0 | 7 |
| SERPINB6 | PPP1R3C | 0.793745 | 11 | 0 | 11 |
| SERPINB6 | CAPN14 | 0.790151 | 6 | 0 | 6 |
| SERPINB6 | KAT2B | 0.789849 | 11 | 0 | 10 |
| SERPINB6 | SH3BGRL2 | 0.788182 | 8 | 0 | 8 |
| SERPINB6 | VSIG10L | 0.786157 | 6 | 0 | 6 |
| SERPINB6 | SASH1 | 0.784675 | 11 | 0 | 11 |
| SERPINB6 | CTTNBP2 | 0.783195 | 6 | 0 | 6 |
| SERPINB6 | CYSRT1 | 0.782674 | 6 | 0 | 6 |
| SERPINB6 | HPGD | 0.781201 | 11 | 0 | 11 |
| SERPINB6 | GYS2 | 0.781134 | 10 | 0 | 10 |
| SERPINB6 | ABLIM3 | 0.780721 | 11 | 0 | 10 |
| SERPINB6 | UBL3 | 0.780018 | 11 | 0 | 10 |
| SERPINB6 | RANBP9 | 0.778716 | 11 | 0 | 11 |
| SERPINB6 | VSIG2 | 0.778424 | 7 | 0 | 7 |
| SERPINB6 | SCNN1B | 0.777625 | 10 | 0 | 10 |
For details and further investigation, click here
