PRKCE

 

Full name: protein kinase C epsilon Alias Symbol: 
Type: protein-coding gene Cytoband: 2p21
Entrez ID: 5581 HGNC ID: HGNC:9401 Ensembl Gene: ENSG00000171132 OMIM ID: 176975
Drug and gene relationship at DGIdb

 

PRKCE involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04530Tight junction
hsa04666Fc gamma R-mediated phagocytosis
hsa04750Inflammatory mediator regulation of TRP channels
hsa04925Aldosterone synthesis and secretion
hsa04930Type II diabetes mellitus
hsa04931Insulin resistance
hsa04933AGE-RAGE signaling pathway in diabetic complications

 

Expression of PRKCE:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKCE 5581 226101_at -0.4312 0.1463
GSE20347 PRKCE 5581 206248_at 0.0974 0.2586
GSE23400 PRKCE 5581 206248_at -0.0615 0.1284
GSE26886 PRKCE 5581 226101_at -0.6629 0.0012
GSE29001 PRKCE 5581 206248_at 0.0505 0.6685
GSE38129 PRKCE 5581 206248_at -0.0922 0.1903
GSE45670 PRKCE 5581 226101_at -0.3852 0.0320
GSE53622 PRKCE 5581 63905 -0.8049 0.0000
GSE53624 PRKCE 5581 77105 -0.7305 0.0000
GSE63941 PRKCE 5581 226101_at -1.8169 0.0044
GSE77861 PRKCE 5581 226101_at 0.0242 0.8740
GSE97050 PRKCE 5581 A_23_P250564 -0.1202 0.6109
SRP007169 PRKCE 5581 RNAseq -0.7348 0.1873
SRP064894 PRKCE 5581 RNAseq -0.6065 0.0129
SRP133303 PRKCE 5581 RNAseq -0.4328 0.0544
SRP159526 PRKCE 5581 RNAseq -0.4409 0.0959
SRP193095 PRKCE 5581 RNAseq -0.1830 0.2274
SRP219564 PRKCE 5581 RNAseq -0.8567 0.0666
TCGA PRKCE 5581 RNAseq -0.3478 0.0000

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by PRKCE expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKCE:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKCE 5581 10 1 19
GSE20123 PRKCE 5581 9 1 20
GSE43470 PRKCE 5581 5 1 37
GSE46452 PRKCE 5581 1 4 54
GSE47630 PRKCE 5581 7 0 33
GSE54993 PRKCE 5581 0 5 65
GSE54994 PRKCE 5581 10 0 43
GSE60625 PRKCE 5581 0 3 8
GSE74703 PRKCE 5581 5 1 30
GSE74704 PRKCE 5581 9 1 10
TCGA PRKCE 5581 35 4 57

Total number of gains: 91; Total number of losses: 21; Total Number of normals: 376.  

 

Somatic mutations of PRKCE:

 

Generating mutation plots.

 

Highly correlated genes for PRKCE:

 

Showing top 20/743 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKCECRYL10.781294404
PRKCERNF2070.766098303
PRKCESF3A10.766094303
PRKCEESYT20.73552404
PRKCEDUSP220.733608303
PRKCEKLHL20.708506303
PRKCENHLH20.70533303
PRKCEZNF2120.70392404
PRKCECDYL0.702619303
PRKCEDCHS20.695243504
PRKCEPCDH180.693797303
PRKCECPT20.693432403
PRKCEHLF0.690659505
PRKCEFAM120AOS0.690029303
PRKCEHOXA40.684327303
PRKCETNFSF80.683487404
PRKCETIFA0.68234403
PRKCEMAP40.68095404
PRKCESLC10A70.679926303
PRKCEMEIS10.679095606

For details and further investigation, click here