| Full name: sphingosine-1-phosphate phosphatase 2 | Alias Symbol: SPP2|FLJ39004 | ||
| Type: protein-coding gene | Cytoband: 2q36.1 | ||
| Entrez ID: 130367 | HGNC ID: HGNC:19953 | Ensembl Gene: ENSG00000163082 | OMIM ID: 612827 |
| Drug and gene relationship at DGIdb | |||
Expression of SGPP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SGPP2 | 130367 | 238567_at | -0.2787 | 0.8495 | |
| GSE26886 | SGPP2 | 130367 | 244780_at | -1.1892 | 0.0653 | |
| GSE45670 | SGPP2 | 130367 | 244780_at | 0.3011 | 0.4110 | |
| GSE53622 | SGPP2 | 130367 | 108882 | -0.2345 | 0.3949 | |
| GSE53624 | SGPP2 | 130367 | 108882 | -0.7560 | 0.0000 | |
| GSE63941 | SGPP2 | 130367 | 238567_at | 1.0650 | 0.3186 | |
| GSE77861 | SGPP2 | 130367 | 238567_at | 0.0847 | 0.8950 | |
| GSE97050 | SGPP2 | 130367 | A_33_P3386547 | 0.4069 | 0.4431 | |
| SRP007169 | SGPP2 | 130367 | RNAseq | -0.9542 | 0.0037 | |
| SRP008496 | SGPP2 | 130367 | RNAseq | -0.6696 | 0.0047 | |
| SRP064894 | SGPP2 | 130367 | RNAseq | -0.8820 | 0.0382 | |
| SRP133303 | SGPP2 | 130367 | RNAseq | -0.1617 | 0.5792 | |
| SRP159526 | SGPP2 | 130367 | RNAseq | 0.0778 | 0.8634 | |
| SRP193095 | SGPP2 | 130367 | RNAseq | -0.7175 | 0.0000 | |
| SRP219564 | SGPP2 | 130367 | RNAseq | -0.4185 | 0.6581 | |
| TCGA | SGPP2 | 130367 | RNAseq | -0.1199 | 0.4397 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SGPP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SGPP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SGPP2 | 130367 | 2 | 13 | 15 | |
| GSE20123 | SGPP2 | 130367 | 2 | 13 | 15 | |
| GSE43470 | SGPP2 | 130367 | 0 | 7 | 36 | |
| GSE46452 | SGPP2 | 130367 | 0 | 5 | 54 | |
| GSE47630 | SGPP2 | 130367 | 4 | 5 | 31 | |
| GSE54993 | SGPP2 | 130367 | 1 | 2 | 67 | |
| GSE54994 | SGPP2 | 130367 | 7 | 10 | 36 | |
| GSE60625 | SGPP2 | 130367 | 3 | 0 | 8 | |
| GSE74703 | SGPP2 | 130367 | 0 | 6 | 30 | |
| GSE74704 | SGPP2 | 130367 | 2 | 7 | 11 | |
| TCGA | SGPP2 | 130367 | 13 | 27 | 56 |
Total number of gains: 34; Total number of losses: 95; Total Number of normals: 359.
Somatic mutations of SGPP2:
Generating mutation plots.
Highly correlated genes for SGPP2:
Showing top 20/294 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SGPP2 | PTBP3 | 0.728587 | 3 | 0 | 3 |
| SGPP2 | FAM83B | 0.723924 | 3 | 0 | 3 |
| SGPP2 | GALE | 0.705947 | 3 | 0 | 3 |
| SGPP2 | KCTD5 | 0.700993 | 4 | 0 | 4 |
| SGPP2 | ARG2 | 0.695343 | 3 | 0 | 3 |
| SGPP2 | FAM110A | 0.69232 | 4 | 0 | 4 |
| SGPP2 | TMEM54 | 0.683688 | 3 | 0 | 3 |
| SGPP2 | C1orf210 | 0.67583 | 4 | 0 | 3 |
| SGPP2 | TRIM7 | 0.675389 | 6 | 0 | 5 |
| SGPP2 | IMPACT | 0.673287 | 3 | 0 | 3 |
| SGPP2 | SPTY2D1 | 0.671305 | 3 | 0 | 3 |
| SGPP2 | CARHSP1 | 0.670565 | 4 | 0 | 3 |
| SGPP2 | RTN4IP1 | 0.67023 | 3 | 0 | 3 |
| SGPP2 | THAP2 | 0.663264 | 3 | 0 | 3 |
| SGPP2 | UCHL3 | 0.658757 | 3 | 0 | 3 |
| SGPP2 | IPPK | 0.657577 | 3 | 0 | 3 |
| SGPP2 | TMEM167A | 0.654669 | 3 | 0 | 3 |
| SGPP2 | BCL10 | 0.650849 | 4 | 0 | 3 |
| SGPP2 | HORMAD1 | 0.64763 | 3 | 0 | 3 |
| SGPP2 | DIAPH1 | 0.644273 | 4 | 0 | 4 |
For details and further investigation, click here
