| Full name: inositol-pentakisphosphate 2-kinase | Alias Symbol: INSP5K2|FLJ13163|IP5K|IPK1 | ||
| Type: protein-coding gene | Cytoband: 9q22.31 | ||
| Entrez ID: 64768 | HGNC ID: HGNC:14645 | Ensembl Gene: ENSG00000127080 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of IPPK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IPPK | 64768 | 219092_s_at | -0.2470 | 0.6662 | |
| GSE20347 | IPPK | 64768 | 219092_s_at | -0.3003 | 0.0417 | |
| GSE23400 | IPPK | 64768 | 219092_s_at | -0.1346 | 0.0832 | |
| GSE26886 | IPPK | 64768 | 219092_s_at | -1.1369 | 0.0008 | |
| GSE29001 | IPPK | 64768 | 219092_s_at | -0.1291 | 0.6770 | |
| GSE38129 | IPPK | 64768 | 219092_s_at | -0.0100 | 0.9634 | |
| GSE45670 | IPPK | 64768 | 219092_s_at | 0.3829 | 0.0280 | |
| GSE63941 | IPPK | 64768 | 219092_s_at | -0.3089 | 0.4672 | |
| GSE77861 | IPPK | 64768 | 219092_s_at | -0.0482 | 0.8271 | |
| GSE97050 | IPPK | 64768 | A_33_P3371514 | 0.3235 | 0.5526 | |
| SRP007169 | IPPK | 64768 | RNAseq | 0.0947 | 0.8210 | |
| SRP008496 | IPPK | 64768 | RNAseq | -0.0150 | 0.9590 | |
| SRP064894 | IPPK | 64768 | RNAseq | -0.3729 | 0.2673 | |
| SRP133303 | IPPK | 64768 | RNAseq | -0.1805 | 0.5141 | |
| SRP159526 | IPPK | 64768 | RNAseq | -1.0866 | 0.0002 | |
| SRP193095 | IPPK | 64768 | RNAseq | -0.1683 | 0.4401 | |
| SRP219564 | IPPK | 64768 | RNAseq | -0.6475 | 0.3408 | |
| TCGA | IPPK | 64768 | RNAseq | 0.3535 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by IPPK expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of IPPK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IPPK | 64768 | 5 | 9 | 16 | |
| GSE20123 | IPPK | 64768 | 5 | 9 | 16 | |
| GSE43470 | IPPK | 64768 | 6 | 3 | 34 | |
| GSE46452 | IPPK | 64768 | 6 | 14 | 39 | |
| GSE47630 | IPPK | 64768 | 1 | 17 | 22 | |
| GSE54993 | IPPK | 64768 | 4 | 2 | 64 | |
| GSE54994 | IPPK | 64768 | 8 | 11 | 34 | |
| GSE60625 | IPPK | 64768 | 0 | 0 | 11 | |
| GSE74703 | IPPK | 64768 | 5 | 3 | 28 | |
| GSE74704 | IPPK | 64768 | 2 | 7 | 11 | |
| TCGA | IPPK | 64768 | 24 | 24 | 48 |
Total number of gains: 66; Total number of losses: 99; Total Number of normals: 323.
Somatic mutations of IPPK:
Generating mutation plots.
Highly correlated genes for IPPK:
Showing top 20/311 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IPPK | BTBD11 | 0.74877 | 3 | 0 | 3 |
| IPPK | C6orf132 | 0.677311 | 4 | 0 | 3 |
| IPPK | KRT6A | 0.670163 | 9 | 0 | 7 |
| IPPK | KCNK6 | 0.669983 | 4 | 0 | 3 |
| IPPK | SFN | 0.663515 | 8 | 0 | 7 |
| IPPK | SGPP2 | 0.657577 | 3 | 0 | 3 |
| IPPK | TTLL12 | 0.655627 | 6 | 0 | 6 |
| IPPK | KRT6B | 0.653342 | 9 | 0 | 8 |
| IPPK | IL17RE | 0.652105 | 3 | 0 | 3 |
| IPPK | GNA15 | 0.649632 | 9 | 0 | 7 |
| IPPK | MREG | 0.646453 | 5 | 0 | 4 |
| IPPK | ATAD3C | 0.644394 | 3 | 0 | 3 |
| IPPK | LIPH | 0.644094 | 4 | 0 | 4 |
| IPPK | DNAH6 | 0.643845 | 5 | 0 | 4 |
| IPPK | CYB5R2 | 0.642925 | 3 | 0 | 3 |
| IPPK | VDR | 0.641764 | 6 | 0 | 5 |
| IPPK | FAM135A | 0.641733 | 4 | 0 | 3 |
| IPPK | FAM83G | 0.639149 | 3 | 0 | 3 |
| IPPK | FAM126B | 0.6354 | 3 | 0 | 3 |
| IPPK | CA12 | 0.634065 | 7 | 0 | 6 |
For details and further investigation, click here
