| Full name: arginase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q24.1 | ||
| Entrez ID: 384 | HGNC ID: HGNC:664 | Ensembl Gene: ENSG00000081181 | OMIM ID: 107830 |
| Drug and gene relationship at DGIdb | |||
Expression of ARG2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARG2 | 384 | 203946_s_at | -0.3940 | 0.6789 | |
| GSE20347 | ARG2 | 384 | 203945_at | -0.2578 | 0.0944 | |
| GSE23400 | ARG2 | 384 | 203945_at | -0.1945 | 0.0002 | |
| GSE26886 | ARG2 | 384 | 203946_s_at | -1.0913 | 0.0397 | |
| GSE29001 | ARG2 | 384 | 203945_at | -0.3839 | 0.1612 | |
| GSE38129 | ARG2 | 384 | 203946_s_at | -0.1751 | 0.6107 | |
| GSE45670 | ARG2 | 384 | 203946_s_at | 0.3414 | 0.4173 | |
| GSE63941 | ARG2 | 384 | 203946_s_at | 2.6232 | 0.0386 | |
| GSE77861 | ARG2 | 384 | 203946_s_at | -1.4278 | 0.0150 | |
| GSE97050 | ARG2 | 384 | A_23_P128728 | -0.1800 | 0.5871 | |
| SRP007169 | ARG2 | 384 | RNAseq | -1.9390 | 0.0001 | |
| SRP008496 | ARG2 | 384 | RNAseq | -2.3933 | 0.0000 | |
| SRP064894 | ARG2 | 384 | RNAseq | -1.2540 | 0.0001 | |
| SRP133303 | ARG2 | 384 | RNAseq | -0.2274 | 0.3682 | |
| SRP159526 | ARG2 | 384 | RNAseq | -1.4935 | 0.0000 | |
| SRP193095 | ARG2 | 384 | RNAseq | -0.7509 | 0.0144 | |
| TCGA | ARG2 | 384 | RNAseq | -0.0330 | 0.6889 |
Upregulated datasets: 1; Downregulated datasets: 6.
Survival by ARG2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ARG2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARG2 | 384 | 7 | 2 | 21 | |
| GSE20123 | ARG2 | 384 | 7 | 2 | 21 | |
| GSE43470 | ARG2 | 384 | 8 | 2 | 33 | |
| GSE46452 | ARG2 | 384 | 16 | 3 | 40 | |
| GSE47630 | ARG2 | 384 | 11 | 9 | 20 | |
| GSE54993 | ARG2 | 384 | 3 | 9 | 58 | |
| GSE54994 | ARG2 | 384 | 18 | 5 | 30 | |
| GSE60625 | ARG2 | 384 | 0 | 2 | 9 | |
| GSE74703 | ARG2 | 384 | 7 | 2 | 27 | |
| GSE74704 | ARG2 | 384 | 3 | 2 | 15 | |
| TCGA | ARG2 | 384 | 33 | 14 | 49 |
Total number of gains: 113; Total number of losses: 52; Total Number of normals: 323.
Somatic mutations of ARG2:
Generating mutation plots.
Highly correlated genes for ARG2:
Showing top 20/221 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARG2 | DECR1 | 0.808336 | 3 | 0 | 3 |
| ARG2 | GTF3C6 | 0.763941 | 3 | 0 | 3 |
| ARG2 | HEYL | 0.758871 | 3 | 0 | 3 |
| ARG2 | FAM83D | 0.750512 | 3 | 0 | 3 |
| ARG2 | RPUSD3 | 0.728041 | 3 | 0 | 3 |
| ARG2 | SVIP | 0.724807 | 3 | 0 | 3 |
| ARG2 | CAMK2D | 0.719056 | 3 | 0 | 3 |
| ARG2 | FBXO32 | 0.717334 | 3 | 0 | 3 |
| ARG2 | ERP44 | 0.715061 | 3 | 0 | 3 |
| ARG2 | PPP1R3B | 0.711872 | 3 | 0 | 3 |
| ARG2 | MRPL30 | 0.710652 | 3 | 0 | 3 |
| ARG2 | ROBO1 | 0.710241 | 3 | 0 | 3 |
| ARG2 | RAB27A | 0.708807 | 4 | 0 | 4 |
| ARG2 | CSF2RA | 0.701478 | 4 | 0 | 4 |
| ARG2 | SEC24B | 0.701429 | 3 | 0 | 3 |
| ARG2 | NR5A2 | 0.700803 | 3 | 0 | 3 |
| ARG2 | KCNJ2 | 0.698737 | 3 | 0 | 3 |
| ARG2 | SGPP2 | 0.695343 | 3 | 0 | 3 |
| ARG2 | MTMR10 | 0.695099 | 4 | 0 | 4 |
| ARG2 | ABHD3 | 0.692071 | 3 | 0 | 3 |
For details and further investigation, click here
