| Full name: ubiquitin C-terminal hydrolase L3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 13q22.2 | ||
| Entrez ID: 7347 | HGNC ID: HGNC:12515 | Ensembl Gene: ENSG00000118939 | OMIM ID: 603090 |
| Drug and gene relationship at DGIdb | |||
Expression of UCHL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UCHL3 | 7347 | 204616_at | -0.3749 | 0.5165 | |
| GSE20347 | UCHL3 | 7347 | 204616_at | -0.6007 | 0.0088 | |
| GSE23400 | UCHL3 | 7347 | 204616_at | -0.2682 | 0.0135 | |
| GSE26886 | UCHL3 | 7347 | 204616_at | -0.2066 | 0.4530 | |
| GSE29001 | UCHL3 | 7347 | 204616_at | -0.3300 | 0.5788 | |
| GSE38129 | UCHL3 | 7347 | 204616_at | -0.1273 | 0.6429 | |
| GSE45670 | UCHL3 | 7347 | 204616_at | 0.0927 | 0.5840 | |
| GSE53622 | UCHL3 | 7347 | 35997 | -0.1802 | 0.0876 | |
| GSE53624 | UCHL3 | 7347 | 35997 | -0.1769 | 0.0204 | |
| GSE63941 | UCHL3 | 7347 | 204616_at | 0.1332 | 0.7688 | |
| GSE77861 | UCHL3 | 7347 | 204616_at | -0.6107 | 0.0216 | |
| GSE97050 | UCHL3 | 7347 | A_23_P76690 | 0.2574 | 0.4373 | |
| SRP007169 | UCHL3 | 7347 | RNAseq | -1.3704 | 0.0003 | |
| SRP008496 | UCHL3 | 7347 | RNAseq | -1.3345 | 0.0000 | |
| SRP064894 | UCHL3 | 7347 | RNAseq | -0.2640 | 0.2360 | |
| SRP133303 | UCHL3 | 7347 | RNAseq | 0.1855 | 0.5259 | |
| SRP159526 | UCHL3 | 7347 | RNAseq | -1.1074 | 0.0014 | |
| SRP193095 | UCHL3 | 7347 | RNAseq | -0.8824 | 0.0000 | |
| SRP219564 | UCHL3 | 7347 | RNAseq | -0.2303 | 0.6390 | |
| TCGA | UCHL3 | 7347 | RNAseq | 0.2261 | 0.0036 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by UCHL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UCHL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UCHL3 | 7347 | 3 | 11 | 16 | |
| GSE20123 | UCHL3 | 7347 | 3 | 10 | 17 | |
| GSE43470 | UCHL3 | 7347 | 4 | 10 | 29 | |
| GSE46452 | UCHL3 | 7347 | 0 | 32 | 27 | |
| GSE47630 | UCHL3 | 7347 | 3 | 27 | 10 | |
| GSE54993 | UCHL3 | 7347 | 11 | 3 | 56 | |
| GSE54994 | UCHL3 | 7347 | 3 | 14 | 36 | |
| GSE60625 | UCHL3 | 7347 | 0 | 3 | 8 | |
| GSE74703 | UCHL3 | 7347 | 3 | 8 | 25 | |
| GSE74704 | UCHL3 | 7347 | 1 | 9 | 10 | |
| TCGA | UCHL3 | 7347 | 12 | 33 | 51 |
Total number of gains: 43; Total number of losses: 160; Total Number of normals: 285.
Somatic mutations of UCHL3:
Generating mutation plots.
Highly correlated genes for UCHL3:
Showing top 20/919 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UCHL3 | ACTR3C | 0.800391 | 3 | 0 | 3 |
| UCHL3 | CHRNB1 | 0.762444 | 3 | 0 | 3 |
| UCHL3 | TMEM161B | 0.752181 | 4 | 0 | 3 |
| UCHL3 | OXNAD1 | 0.750801 | 3 | 0 | 3 |
| UCHL3 | ZSWIM6 | 0.731635 | 3 | 0 | 3 |
| UCHL3 | GPBP1 | 0.728016 | 3 | 0 | 3 |
| UCHL3 | RAB42 | 0.719994 | 3 | 0 | 3 |
| UCHL3 | RPP38 | 0.71754 | 3 | 0 | 3 |
| UCHL3 | RRAGA | 0.713649 | 5 | 0 | 5 |
| UCHL3 | PGM2 | 0.71214 | 6 | 0 | 5 |
| UCHL3 | TRIM22 | 0.706675 | 3 | 0 | 3 |
| UCHL3 | SESN2 | 0.700846 | 4 | 0 | 4 |
| UCHL3 | ATP6V1G1 | 0.696607 | 5 | 0 | 5 |
| UCHL3 | SNAPC3 | 0.694017 | 3 | 0 | 3 |
| UCHL3 | TBC1D22B | 0.693546 | 3 | 0 | 3 |
| UCHL3 | C6orf132 | 0.69327 | 3 | 0 | 3 |
| UCHL3 | CUL4B | 0.692143 | 4 | 0 | 4 |
| UCHL3 | MTOR | 0.691445 | 3 | 0 | 3 |
| UCHL3 | RAP2C | 0.690589 | 7 | 0 | 6 |
| UCHL3 | C2orf16 | 0.683856 | 3 | 0 | 3 |
For details and further investigation, click here
