| Full name: GLI family zinc finger 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q13.3 | ||
| Entrez ID: 2735 | HGNC ID: HGNC:4317 | Ensembl Gene: ENSG00000111087 | OMIM ID: 165220 |
| Drug and gene relationship at DGIdb | |||
GLI1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04340 | Hedgehog signaling pathway | |
| hsa05200 | Pathways in cancer | |
| hsa05217 | Basal cell carcinoma |
Expression of GLI1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GLI1 | 2735 | 206646_at | 0.1716 | 0.6512 | |
| GSE20347 | GLI1 | 2735 | 206646_at | 0.1836 | 0.0093 | |
| GSE23400 | GLI1 | 2735 | 206646_at | 0.1514 | 0.0196 | |
| GSE26886 | GLI1 | 2735 | 206646_at | 0.5547 | 0.0003 | |
| GSE29001 | GLI1 | 2735 | 206646_at | -0.1774 | 0.3758 | |
| GSE38129 | GLI1 | 2735 | 206646_at | 0.1582 | 0.2159 | |
| GSE45670 | GLI1 | 2735 | 206646_at | 0.0158 | 0.9346 | |
| GSE53622 | GLI1 | 2735 | 99677 | 1.7981 | 0.0000 | |
| GSE53624 | GLI1 | 2735 | 77971 | 2.4289 | 0.0000 | |
| GSE63941 | GLI1 | 2735 | 206646_at | 0.1327 | 0.6071 | |
| GSE77861 | GLI1 | 2735 | 206646_at | 0.2520 | 0.2081 | |
| SRP007169 | GLI1 | 2735 | RNAseq | 7.0221 | 0.0000 | |
| SRP133303 | GLI1 | 2735 | RNAseq | 1.4931 | 0.0004 | |
| SRP159526 | GLI1 | 2735 | RNAseq | 3.9121 | 0.0000 | |
| SRP193095 | GLI1 | 2735 | RNAseq | 2.4867 | 0.0000 | |
| SRP219564 | GLI1 | 2735 | RNAseq | 1.7089 | 0.0437 | |
| TCGA | GLI1 | 2735 | RNAseq | 0.4603 | 0.1688 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by GLI1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GLI1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GLI1 | 2735 | 6 | 1 | 23 | |
| GSE20123 | GLI1 | 2735 | 6 | 0 | 24 | |
| GSE43470 | GLI1 | 2735 | 2 | 0 | 41 | |
| GSE46452 | GLI1 | 2735 | 8 | 1 | 50 | |
| GSE47630 | GLI1 | 2735 | 10 | 2 | 28 | |
| GSE54993 | GLI1 | 2735 | 0 | 5 | 65 | |
| GSE54994 | GLI1 | 2735 | 4 | 1 | 48 | |
| GSE60625 | GLI1 | 2735 | 0 | 0 | 11 | |
| GSE74703 | GLI1 | 2735 | 2 | 0 | 34 | |
| GSE74704 | GLI1 | 2735 | 4 | 0 | 16 | |
| TCGA | GLI1 | 2735 | 14 | 10 | 72 |
Total number of gains: 56; Total number of losses: 20; Total Number of normals: 412.
Somatic mutations of GLI1:
Generating mutation plots.
Highly correlated genes for GLI1:
Showing top 20/523 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GLI1 | IQSEC2 | 0.731802 | 3 | 0 | 3 |
| GLI1 | CDC42EP2 | 0.724658 | 3 | 0 | 3 |
| GLI1 | PCBP4 | 0.702523 | 4 | 0 | 4 |
| GLI1 | WNT8B | 0.702142 | 3 | 0 | 3 |
| GLI1 | ADAMTS12 | 0.687212 | 5 | 0 | 5 |
| GLI1 | GLI2 | 0.686383 | 10 | 0 | 10 |
| GLI1 | SNAPC2 | 0.686057 | 4 | 0 | 4 |
| GLI1 | SH3BP1 | 0.68555 | 4 | 0 | 4 |
| GLI1 | LYZL6 | 0.68478 | 3 | 0 | 3 |
| GLI1 | PROX1 | 0.679081 | 4 | 0 | 4 |
| GLI1 | SCN1B | 0.678972 | 3 | 0 | 3 |
| GLI1 | WDR54 | 0.67051 | 5 | 0 | 5 |
| GLI1 | GPR162 | 0.666644 | 3 | 0 | 3 |
| GLI1 | TSPYL2 | 0.666199 | 3 | 0 | 3 |
| GLI1 | APBB1 | 0.663851 | 3 | 0 | 3 |
| GLI1 | LTB4R2 | 0.659629 | 3 | 0 | 3 |
| GLI1 | CASC15 | 0.65827 | 4 | 0 | 3 |
| GLI1 | XPR1 | 0.655969 | 5 | 0 | 5 |
| GLI1 | COL1A1 | 0.655127 | 5 | 0 | 5 |
| GLI1 | TTC7B | 0.653347 | 3 | 0 | 3 |
For details and further investigation, click here
