| Full name: serpin family B member 5 | Alias Symbol: maspin | ||
| Type: protein-coding gene | Cytoband: 18q21.33 | ||
| Entrez ID: 5268 | HGNC ID: HGNC:8949 | Ensembl Gene: ENSG00000206075 | OMIM ID: 154790 |
| Drug and gene relationship at DGIdb | |||
SERPINB5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04115 | p53 signaling pathway |
Expression of SERPINB5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERPINB5 | 5268 | 204855_at | -0.1460 | 0.8916 | |
| GSE20347 | SERPINB5 | 5268 | 204855_at | -0.8132 | 0.0002 | |
| GSE23400 | SERPINB5 | 5268 | 204855_at | -0.1732 | 0.3165 | |
| GSE26886 | SERPINB5 | 5268 | 204855_at | -1.3395 | 0.0006 | |
| GSE29001 | SERPINB5 | 5268 | 204855_at | -0.5545 | 0.1763 | |
| GSE38129 | SERPINB5 | 5268 | 204855_at | 0.6098 | 0.3889 | |
| GSE45670 | SERPINB5 | 5268 | 204855_at | 0.1229 | 0.4408 | |
| GSE53622 | SERPINB5 | 5268 | 92780 | -0.3971 | 0.1574 | |
| GSE53624 | SERPINB5 | 5268 | 92780 | -0.8708 | 0.0000 | |
| GSE63941 | SERPINB5 | 5268 | 204855_at | 6.2368 | 0.0000 | |
| GSE77861 | SERPINB5 | 5268 | 204855_at | 0.0315 | 0.9549 | |
| GSE97050 | SERPINB5 | 5268 | A_33_P3310104 | 0.8812 | 0.4238 | |
| SRP007169 | SERPINB5 | 5268 | RNAseq | -1.5512 | 0.0019 | |
| SRP008496 | SERPINB5 | 5268 | RNAseq | -1.3344 | 0.0000 | |
| SRP064894 | SERPINB5 | 5268 | RNAseq | -0.9145 | 0.0835 | |
| SRP133303 | SERPINB5 | 5268 | RNAseq | -0.1994 | 0.5934 | |
| SRP159526 | SERPINB5 | 5268 | RNAseq | -0.6840 | 0.2425 | |
| SRP193095 | SERPINB5 | 5268 | RNAseq | -0.6614 | 0.0254 | |
| SRP219564 | SERPINB5 | 5268 | RNAseq | -1.0151 | 0.4251 | |
| TCGA | SERPINB5 | 5268 | RNAseq | 1.2336 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 3.
Survival by SERPINB5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERPINB5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERPINB5 | 5268 | 1 | 9 | 20 | |
| GSE20123 | SERPINB5 | 5268 | 1 | 9 | 20 | |
| GSE43470 | SERPINB5 | 5268 | 0 | 7 | 36 | |
| GSE46452 | SERPINB5 | 5268 | 1 | 26 | 32 | |
| GSE47630 | SERPINB5 | 5268 | 5 | 21 | 14 | |
| GSE54993 | SERPINB5 | 5268 | 9 | 0 | 61 | |
| GSE54994 | SERPINB5 | 5268 | 1 | 18 | 34 | |
| GSE60625 | SERPINB5 | 5268 | 0 | 4 | 7 | |
| GSE74703 | SERPINB5 | 5268 | 0 | 7 | 29 | |
| GSE74704 | SERPINB5 | 5268 | 1 | 6 | 13 | |
| TCGA | SERPINB5 | 5268 | 10 | 45 | 41 |
Total number of gains: 29; Total number of losses: 152; Total Number of normals: 307.
Somatic mutations of SERPINB5:
Generating mutation plots.
Highly correlated genes for SERPINB5:
Showing top 20/678 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERPINB5 | DSG3 | 0.798737 | 13 | 0 | 12 |
| SERPINB5 | KRT6C | 0.766086 | 4 | 0 | 4 |
| SERPINB5 | JUP | 0.74763 | 11 | 0 | 10 |
| SERPINB5 | CERS3 | 0.734634 | 6 | 0 | 6 |
| SERPINB5 | SH3BP1 | 0.729937 | 4 | 0 | 4 |
| SERPINB5 | KRT6B | 0.729438 | 13 | 0 | 13 |
| SERPINB5 | TMEM154 | 0.727278 | 6 | 0 | 6 |
| SERPINB5 | DSC2 | 0.72531 | 13 | 0 | 11 |
| SERPINB5 | FAM83C | 0.724306 | 6 | 0 | 5 |
| SERPINB5 | FAM160A1 | 0.724181 | 6 | 0 | 6 |
| SERPINB5 | KRT6A | 0.723293 | 12 | 0 | 12 |
| SERPINB5 | CLCA2 | 0.716486 | 11 | 0 | 10 |
| SERPINB5 | LPAR5 | 0.715334 | 8 | 0 | 7 |
| SERPINB5 | ABHD17C | 0.714665 | 3 | 0 | 3 |
| SERPINB5 | DSC3 | 0.711792 | 13 | 0 | 11 |
| SERPINB5 | DSP | 0.710532 | 12 | 0 | 11 |
| SERPINB5 | GJB5 | 0.710282 | 12 | 0 | 12 |
| SERPINB5 | TRIM29 | 0.705959 | 11 | 0 | 9 |
| SERPINB5 | S100A2 | 0.705405 | 12 | 0 | 10 |
| SERPINB5 | FGFBP1 | 0.701107 | 13 | 0 | 12 |
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