| Full name: sphingomyelin phosphodiesterase 3 | Alias Symbol: NSMASE2 | ||
| Type: protein-coding gene | Cytoband: 16q22.1 | ||
| Entrez ID: 55512 | HGNC ID: HGNC:14240 | Ensembl Gene: ENSG00000103056 | OMIM ID: 605777 |
| Drug and gene relationship at DGIdb | |||
Expression of SMPD3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMPD3 | 55512 | 219695_at | -0.0980 | 0.7672 | |
| GSE20347 | SMPD3 | 55512 | 219695_at | -0.0993 | 0.3222 | |
| GSE23400 | SMPD3 | 55512 | 219695_at | -0.1241 | 0.0000 | |
| GSE26886 | SMPD3 | 55512 | 219695_at | 0.1549 | 0.4794 | |
| GSE29001 | SMPD3 | 55512 | 219695_at | -0.3968 | 0.0341 | |
| GSE38129 | SMPD3 | 55512 | 219695_at | -0.1987 | 0.0772 | |
| GSE45670 | SMPD3 | 55512 | 219695_at | -0.0488 | 0.8376 | |
| GSE63941 | SMPD3 | 55512 | 219695_at | 0.0736 | 0.7995 | |
| GSE77861 | SMPD3 | 55512 | 231732_at | -0.0280 | 0.8779 | |
| GSE97050 | SMPD3 | 55512 | A_23_P163567 | 0.3617 | 0.2702 | |
| SRP007169 | SMPD3 | 55512 | RNAseq | -2.2797 | 0.0151 | |
| SRP064894 | SMPD3 | 55512 | RNAseq | -0.9980 | 0.0002 | |
| SRP133303 | SMPD3 | 55512 | RNAseq | -1.1945 | 0.0002 | |
| SRP159526 | SMPD3 | 55512 | RNAseq | -0.8829 | 0.1105 | |
| SRP193095 | SMPD3 | 55512 | RNAseq | -1.8296 | 0.0002 | |
| SRP219564 | SMPD3 | 55512 | RNAseq | -1.5081 | 0.0014 | |
| TCGA | SMPD3 | 55512 | RNAseq | -1.2432 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by SMPD3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SMPD3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMPD3 | 55512 | 9 | 1 | 20 | |
| GSE20123 | SMPD3 | 55512 | 9 | 1 | 20 | |
| GSE43470 | SMPD3 | 55512 | 1 | 9 | 33 | |
| GSE46452 | SMPD3 | 55512 | 38 | 1 | 20 | |
| GSE47630 | SMPD3 | 55512 | 11 | 8 | 21 | |
| GSE54993 | SMPD3 | 55512 | 2 | 4 | 64 | |
| GSE54994 | SMPD3 | 55512 | 8 | 10 | 35 | |
| GSE60625 | SMPD3 | 55512 | 4 | 0 | 7 | |
| GSE74703 | SMPD3 | 55512 | 1 | 6 | 29 | |
| GSE74704 | SMPD3 | 55512 | 5 | 0 | 15 | |
| TCGA | SMPD3 | 55512 | 31 | 12 | 53 |
Total number of gains: 119; Total number of losses: 52; Total Number of normals: 317.
Somatic mutations of SMPD3:
Generating mutation plots.
Highly correlated genes for SMPD3:
Showing top 20/157 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMPD3 | SH3BP1 | 0.726347 | 3 | 0 | 3 |
| SMPD3 | TMEM238 | 0.68164 | 3 | 0 | 3 |
| SMPD3 | KLK6 | 0.671141 | 4 | 0 | 3 |
| SMPD3 | SPX | 0.66928 | 4 | 0 | 3 |
| SMPD3 | S100A3 | 0.658148 | 3 | 0 | 3 |
| SMPD3 | CAMP | 0.658033 | 3 | 0 | 3 |
| SMPD3 | SYT5 | 0.656048 | 4 | 0 | 4 |
| SMPD3 | CHST8 | 0.64812 | 3 | 0 | 3 |
| SMPD3 | IGF2-AS | 0.645507 | 3 | 0 | 3 |
| SMPD3 | ALDH3B1 | 0.633945 | 4 | 0 | 3 |
| SMPD3 | TRIM63 | 0.63281 | 3 | 0 | 3 |
| SMPD3 | COG4 | 0.629498 | 4 | 0 | 3 |
| SMPD3 | TMC6 | 0.628669 | 4 | 0 | 3 |
| SMPD3 | FGF17 | 0.627049 | 3 | 0 | 3 |
| SMPD3 | LLGL2 | 0.625177 | 4 | 0 | 3 |
| SMPD3 | DPF1 | 0.623088 | 3 | 0 | 3 |
| SMPD3 | CPSF1 | 0.622812 | 3 | 0 | 3 |
| SMPD3 | CTLA4 | 0.617737 | 5 | 0 | 4 |
| SMPD3 | SLC5A1 | 0.616794 | 5 | 0 | 4 |
| SMPD3 | GJA3 | 0.61653 | 4 | 0 | 3 |
For details and further investigation, click here
