| Full name: calcium voltage-gated channel auxiliary subunit gamma 4 | Alias Symbol: MGC11138|MGC24983 | ||
| Type: protein-coding gene | Cytoband: 17q24.2 | ||
| Entrez ID: 27092 | HGNC ID: HGNC:1408 | Ensembl Gene: ENSG00000075461 | OMIM ID: 606404 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CACNG4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04261 | Adrenergic signaling in cardiomyocytes | |
| hsa04921 | Oxytocin signaling pathway |
Expression of CACNG4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CACNG4 | 27092 | 62987_r_at | -0.0151 | 0.9623 | |
| GSE20347 | CACNG4 | 27092 | 62987_r_at | 0.1103 | 0.2231 | |
| GSE23400 | CACNG4 | 27092 | 62987_r_at | -0.0116 | 0.7236 | |
| GSE26886 | CACNG4 | 27092 | 62987_r_at | 0.1036 | 0.5873 | |
| GSE29001 | CACNG4 | 27092 | 62987_r_at | -0.2270 | 0.1092 | |
| GSE38129 | CACNG4 | 27092 | 62987_r_at | 0.0151 | 0.8815 | |
| GSE45670 | CACNG4 | 27092 | 62987_r_at | 0.0789 | 0.2752 | |
| GSE53622 | CACNG4 | 27092 | 143337 | 1.5936 | 0.0000 | |
| GSE53624 | CACNG4 | 27092 | 143337 | 1.5542 | 0.0000 | |
| GSE63941 | CACNG4 | 27092 | 62987_r_at | 0.9117 | 0.0001 | |
| GSE77861 | CACNG4 | 27092 | 62987_r_at | 0.0385 | 0.7718 | |
| GSE97050 | CACNG4 | 27092 | A_24_P70303 | 0.1536 | 0.5574 | |
| SRP159526 | CACNG4 | 27092 | RNAseq | 4.3547 | 0.0000 | |
| TCGA | CACNG4 | 27092 | RNAseq | 0.3336 | 0.3973 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by CACNG4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CACNG4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CACNG4 | 27092 | 3 | 2 | 25 | |
| GSE20123 | CACNG4 | 27092 | 3 | 2 | 25 | |
| GSE43470 | CACNG4 | 27092 | 5 | 0 | 38 | |
| GSE46452 | CACNG4 | 27092 | 31 | 1 | 27 | |
| GSE47630 | CACNG4 | 27092 | 7 | 1 | 32 | |
| GSE54993 | CACNG4 | 27092 | 2 | 5 | 63 | |
| GSE54994 | CACNG4 | 27092 | 9 | 4 | 40 | |
| GSE60625 | CACNG4 | 27092 | 4 | 2 | 5 | |
| GSE74703 | CACNG4 | 27092 | 5 | 0 | 31 | |
| GSE74704 | CACNG4 | 27092 | 3 | 1 | 16 | |
| TCGA | CACNG4 | 27092 | 28 | 9 | 59 |
Total number of gains: 100; Total number of losses: 27; Total Number of normals: 361.
Somatic mutations of CACNG4:
Generating mutation plots.
Highly correlated genes for CACNG4:
Showing top 20/900 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CACNG4 | UCN3 | 0.778543 | 3 | 0 | 3 |
| CACNG4 | CACNG8 | 0.759837 | 3 | 0 | 3 |
| CACNG4 | TXNDC2 | 0.758627 | 5 | 0 | 5 |
| CACNG4 | ACR | 0.734074 | 8 | 0 | 8 |
| CACNG4 | KCNH3 | 0.731266 | 4 | 0 | 4 |
| CACNG4 | SHC2 | 0.728888 | 4 | 0 | 4 |
| CACNG4 | MYH14 | 0.726176 | 4 | 0 | 3 |
| CACNG4 | MRAP | 0.719477 | 4 | 0 | 3 |
| CACNG4 | ABCA4 | 0.713799 | 6 | 0 | 5 |
| CACNG4 | SNORA71A | 0.70938 | 4 | 0 | 4 |
| CACNG4 | ZNF236 | 0.707575 | 7 | 0 | 7 |
| CACNG4 | STAC2 | 0.704681 | 5 | 0 | 5 |
| CACNG4 | AMHR2 | 0.702553 | 9 | 0 | 8 |
| CACNG4 | BCAN | 0.693812 | 7 | 0 | 6 |
| CACNG4 | TRPM3 | 0.693087 | 5 | 0 | 4 |
| CACNG4 | ART5 | 0.691129 | 3 | 0 | 3 |
| CACNG4 | CAMK2B | 0.690084 | 9 | 0 | 8 |
| CACNG4 | GFRA4 | 0.68875 | 8 | 0 | 6 |
| CACNG4 | PRB4 | 0.68659 | 9 | 0 | 8 |
| CACNG4 | POLM | 0.685847 | 3 | 0 | 3 |
For details and further investigation, click here
