SHC4

 

Full name: SHC adaptor protein 4 Alias Symbol: RaLP|SHCD
Type: protein-coding gene Cytoband: 15q21.1
Entrez ID: 399694 HGNC ID: HGNC:16743 Ensembl Gene: ENSG00000185634 OMIM ID: 617372

 

SHC4 involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04510Focal adhesion
hsa04650Natural killer cell mediated cytotoxicity
hsa04722Neurotrophin signaling pathway
hsa04910Insulin signaling pathway
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa05214Glioma
hsa05220Chronic myeloid leukemia

 

Expression of SHC4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SHC4 399694 235238_at -0.1282 0.8162
GSE26886 SHC4 399694 230538_at -0.0538 0.6190
GSE45670 SHC4 399694 235238_at -0.2866 0.1068
GSE53622 SHC4 399694 142704 0.0903 0.6526
GSE53624 SHC4 399694 142704 0.2285 0.1343
GSE63941 SHC4 399694 235238_at -3.6760 0.0000
GSE77861 SHC4 399694 235238_at 0.2306 0.0075
GSE97050 SHC4 399694 A_32_P234145 -0.0739 0.7366
SRP133303 SHC4 399694 RNAseq 0.1170 0.7700
TCGA SHC4 399694 RNAseq -0.1846 0.5206

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by SHC4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SHC4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SHC4 399694 5 3 22
GSE20123 SHC4 399694 5 3 22
GSE43470 SHC4 399694 5 4 34
GSE46452 SHC4 399694 3 7 49
GSE47630 SHC4 399694 8 10 22
GSE54993 SHC4 399694 4 6 60
GSE54994 SHC4 399694 5 7 41
GSE60625 SHC4 399694 4 0 7
GSE74703 SHC4 399694 5 3 28
GSE74704 SHC4 399694 2 3 15
TCGA SHC4 399694 10 17 69

Total number of gains: 56; Total number of losses: 63; Total Number of normals: 369.  

 

Somatic mutations of SHC4:

 

Generating mutation plots.

 

Highly correlated genes for SHC4:

 

Showing top 20/180 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SHC4SOX50.723315303
SHC4FAT40.712335404
SHC4GABARAPL10.696034403
SHC4ADCY90.690205303
SHC4NR4A30.68605303
SHC4DLC10.6787303
SHC4SYT110.678664504
SHC4GALNT150.672213403
SHC4S1PR10.671925303
SHC4MSANTD40.667768303
SHC4PTGFR0.666028403
SHC4SQSTM10.657067303
SHC4C20orf1940.656117303
SHC4CEBPD0.650218303
SHC4FZD70.65013504
SHC4BCL60.648447303
SHC4FGFR10.644179403
SHC4SNPH0.643332303
SHC4SYDE10.642916403
SHC4MFAP40.642889303

For details and further investigation, click here